Human Sera
Cayman Chemical VIlazodonhydrochlorIde 50mg
An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM, respectively); increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex at 1 and 3 mg/kg, i.p.; decreases immobility in the forced swim test in both rats and mice at 1 mg/kg
Cayman Chemical TopIroxostat 50mg
An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); inhibits ABCG2 in isolated human plasma (IC50 = 0.18 µM); increases LPS-induced decreases in Bcl-2 levels and decreases LPS-induced increases of Bax and cleaved caspase-3 levels in H9c2 rat cardiomyocytes at 5 µM; chronic administration results in the presence of urinary xanthine crystals and induces nephropathy in rats at 0.2 and 1 mg/kg, respectively
Cayman Chemical 1PalmItoyl2ArachIdonylsn 100mg
A phospholipid; found in biological membranes; is oxidized in vivo and has been used to study signaling of oxidized phospholipids; levels are decreased in isolated human multiple myeloma cells
Cayman Chemical UDPNacetylDGlucosamIns 50mg
A nucleotide sugar that is used by glycosyltransferases to transfer N-acetylglucosamine residues to substrates
Cayman Chemical ParaquatchlorIde 100mg
An herbicide; induces light-dependent apoptosis and reduces chlorophyll levels in tobacco leaf discs at 10 µM; eliminates susceptible barley grass but not the paraquat-resistant biotype in field studies at 0.05, 0.1, and 0.2 kg/ha; induces apoptosis, increases intracellular levels of NO, and increases expression of mRNA encoding iNOS in SH-SY5Y cells at 100 µM; toxic to rats (LD50s = 115 and 21 mg/kg for p.o. and i.v. administration, respectively); induces neuronal cell death and seizures, effects that can be inhibited by U-74389G, in rats at 100 nmol/animal, i.c.v.; induces weight loss, lung hemorrhage and edema, and diarrhea in rats at 20 mg/kg
Cayman Chemical VImseltInIb 50mg
An inhibitor of CSF1R (IC50 = 3.7 nM); selective for CSF1R over FLT3, PDGFRα, PDGFRβ, and KIT (IC50s = >3,300, 436, 2,300, and 476 nM, respectively; inhibits the proliferation of M-NFS-60 cells (IC50 = 18 nM); inhibits CSF1-induced CFS1R autophosphorylation in THP-1 cells (IC50 = 27 nM) and CSF1- and RANKL-induced osteoclast differentiation (IC50 = 9.3 nM)
Cayman Chemical Cholesterolplnt 100mg
A minor plant sterol; a precursor in the synthesis of various bioactive plant metabolites
Cayman Chemical 1PalmItoyl2oleoyl3lInole 50mg
POL is a common triglyceride component in seed and vegetable oils including olive, sesame, soybean, canola, corn, hazelnut, and many others. POL is one of the standard triglyceride components used for the USP analysis of sesame oil for pharmaceutical applications.{8754}
Cayman Chemical Stearoyl EthnolamIde 50mg
A member of the family of fatty N-acyl ethanolamines collectively called anandamides and the most abundant of several fatty acid ethanolamides produced by the PLD hydrolysis of mouse neuroblastoma cell membrane phospholipids; its specific role in the cannabinergic system remains to be elucidated
Cayman Chemical N-ArachIdonyl DopamIn 50mg
An arachidonoyl amino acid and CB1 receptor agonist (Ki = 250 nM in rat brain membranes, which highly express CB1 receptors); selective for CB1 over CB2 receptors (Ki = 12,000 nM in rat spleen membranes, which highly express CB2 receptors); induces intracellular calcium mobilization in N18TG2 neuroblastoma cells (EC50 = 0.7 µM); inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 0.25 µM); induces hypothermia, catalepsy, hypolocomotion, and analgesia in mice at 10 mg/kg
Cayman Chemical PDMPhydrochlorIde 100mg
A ceramide analog that contains a mixture of all four possible stereoisomers; inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates and inhibits β-1,4-galactosyltransferase 6, however, the inhibitory activity on both enzymes is attributed to the D-threo enantiomer; enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro
Cayman Chemical PAPA Nonate 50mg
PAPA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 15 minutes and 77 minutes at 37°C and 22-25°C, respectively, pH 7.4, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Cayman Chemical DocosapentaenoIc AcId 100mg
Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}