Human Sera
Cayman Chemical Endosulfn II 50mg
An organochlorine insecticide; active against a variety of insects including bollworms and tobacco budworms (LD50s = 4.14 and 4.95 mg/g, respectively); binds to GABA receptors (IC50 = 60 nM in rat brain membranes); toxic to rats (LD50 = 240 mg/kg)
Cayman Chemical mAIhydrochlorIde 50mg
A psychoactive aminoindan which can be found in recreational drug mixtures; potently inhibits serotonin uptake (IC50 = 212 nM) and stimulates its release without inducing neurotoxicity
Cayman Chemical DOIhydrochlorIde 50mg
An analytical reference standard categorized as an amphetamine and phenethylamine; has psychotomimetic properties and abuse has been reported; intended for research and forensic applications
Cayman Chemical Mycophenolate MofetIl 50mg
A prodrug form of mycophenolic acid; inhibits thymidine incorporation in primary rat aortic smooth muscle cells at 1 and 10 UG/ml; increases the duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation at 12.5 mg/kg; eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats at 25 mg/kg; lowers MAP and reduces urinary albumin excretion and glomerulosclerosis in a mouse model of SLE at 60 mg/kg
Cayman Chemical BIcalutamIde 100mg
A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones
Cayman Chemical RopIdoxurIdIn 50mg
A radiosensitizer and a prodrug form of idoxuridine; inhibits viral plaque formation in HSV-1- or HSV-2-HeLa infected cells at 100 µM; enhances radiation-induced decreases in tumor growth without reducing body weight in an HT-29 colon cancer mouse xenograft model at 1,000 mg/kg per day for six days; increases animal survival in a mouse model of lethal HSV-2 infection at 100 mg/kg every five days
Cayman Chemical MIbefradIlhydrochlorIde 50mg
A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM, respectively); a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM
Cayman Chemical N-AcetylserotonIn 100mg
The immediate precursor of melatonin that is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase; acts as an agonist at the melatonin receptors MT1, MT2, and MT3
Cayman Chemical N 3pyrIdylIndomethacIn am 50mg
N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 52 nM. It is about 1,300 times less potent as an inhibitor of ovine COX-1.{8243} However, N-3PyIA does not distinguish between ovine COX-1 and -2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.{8513}
Cayman Chemical 3 4DIhydroxyphenyl ethnol 50mg
3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 µM, respectively. It does not inhibit, and may actually enhance, COX activity.{4049} 3,4-Dihydroxyphenyl ethanol also protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis.{6597}
Cayman Chemical GemcItabInhydrochlorIde 100mg
An active metabolite of NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates; cytotoxic to HepG2 and A549 cells (IC50s = 5.2 and 16 nM, respectively); inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models; sensitizes tumors to PD-1-targeting antibodies, decreases the number of tumor-infiltrating Tregs, and increases survival in an MC-38 syngeneic mouse model of colon carcinoma at 12 mg/kg
Cayman Chemical N 2phenylethylIndomethacI 50mg
N-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively.{8243,8513} It is over 400 times less potent as an inhibitor of ovine COX-1.{8513}
Cayman Chemical LasofoxIfentartrate 50mg
A third-generation SERM that selectively binds to human ERα (IC50 = 1.5 nM) and inhibits bone loss in ovariectomized rats; used in the treatment of postmenopausal osteoporosis and ER-positive breast cancer; also acts as an inverse agonist at the CB2 cannabinoid receptor