Human Sera
Cayman Chemical Caryophylen oxIde 100mg
A bicyclic sesquiterpene; a metabolite of β-caryophyllene that has been found in C. sativa; does not bind to the cannabinoid (CB) receptor CB2 (Ki = >20 µM); induces calcium currents in HL-60 cells expressing CB2 receptors but also does so in CB2-deficient cells; cytotoxic to HepG2, AGS, HeLa, SNU-1 and SNU-16 cells (IC50s = 3.95, 12.6, 13.55, 16.79, and 27.39 µM, respectively); the volatile component of C. sativa sensed by narcotic detection dogs
Cayman Chemical ThymopentIn 50mg
A pentapeptide fragment of thymopoietin; induces prothymocyte differentiation in isolated mouse splenocytes at 0.018-18 µM; increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human PBLs at 1 UG/ml; reduces the number of splenic autologous rosette-forming cells in athymic mice at 0.02-10 mg/kg; adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model
Cayman Chemical AzatdInmaleate 100mg
An antihistamine with anticholinergic and antiserotonergic activities; histamine H1 receptor antagonist (Ki = 3.9 nM); inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and 5-HT-induced contractions in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively); delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs; prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 μg/kg, respectively); increases survival in guinea pig and mouse models of anaphylactic shock (PD50s = 0.024 and 0.019 mg/kg, respectively)
Cayman Chemical Glycyrhza uralens Lqurtn 50mg
A flavonoid with diverse biological activities; inhibits corticosterone-induced apoptosis in PC12 cells at 1 and 2 mg/ml; reduces spinal cord levels of IL-1β, IL-6, and TNF-α and alleviates mechanical and cold allodynia, as well as thermal hyperalgesia, in a mouse model of neuropathic pain induced by CCI of the sciatic nerve at 120 mg/kg; decreases the viability of SiHa, CaSki, and HeLa cervical cancer cells and inhibits migration and invasion of SiHa cells in vitro at 40, 60, and 80 μM; reduces tumor growth in a SiHa mouse xenograft model at 10, 20, and 30 mg/kg
Cayman Chemical SophocarpIn 50mg
An alkaloid with diverse biological activities; cytotoxic to various cancer cell lines (IC50s = 1.64-12.86 mM); nematocidal against B. xylophilus in vitro; reduces infarct size, cardiac muscle fiber swelling and hypertrophy, and neutrophil infiltration in a rat model of myocardial ischemia and reperfusion injury at 30 mg/kg; decreases liver weight, fibrosis, and levels of IL-6, TNF-α, and TGF-β1 in a rat model of NASH; reduces carrageenan-induced hind paw edema in rats and decreases acetic acid-induced writhing in mice at 15 and 30 mg/kg
Cayman Chemical Desvaleryl Valsartn 50mg
A potential impurity found in commercial preparations of valsartan; a degradation product formed under acidic conditions
Cayman Chemical AtractylodIn 50mg
A polyethylene alkyne with diverse biological activities; inhibits NAAA (IC50 = 2.81 µM for the human enzyme); increases levels of palmitoyl ethanolamide and oleoyl ethanolamide in LPS-stimulated BV-2 cells at 10 µM; cytotoxic to CL-6 and HuCC-T1 cells (IC50s = 41.66 and 38.78 µM, respectively); increases the gastric emptying rate in mice at 10 mg/kg; decreases pulmonary edema in a mouse model of LPS-induced acute lung injury at 40 and 80 mg/kg
Cayman Chemical TelmIsartn 100mg
A nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM); a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM); potently reduces blood pressure
Cayman Chemical TrIgonlaDIoscIn 50mg
A natural steroid saponin that inhibits proliferation and induces apoptosis in cancer cells; has antioxidant activity and induces autophagy
Cayman Chemical D-nopterIn 100mg
An intermediate product in the synthetic pathway of biopterin that is released from macrophages upon immune stimulation with interferon-γ from activated T cells; routinely used as a biochemical tool to screen for and monitor the progression of certain diseases accompanied by hyperimmune stimulation
Cayman Chemical DLRythroPPMPhydroCLOrId 100mg
A stereoisomer of DL-threo-PPMP; has no effect on glucosylceramide synthetase activity; used as a negative control for DL-threo-PPMP, D-threo-PPMP, and L-threo-PPMP inhibitory activity
Cayman Chemical Frtlara thunberg Pemn 50mg
An alkaloid with diverse biological activities; an inhibitor of Nav1.7 (IC50= 47.2 µM) and hERG (IC50 = 43.7 µM); increases the latent period of coughs, decreases the number of coughs, and has expectorant activity in a mouse model of ammonia liquor-induced cough at 3 mg/kg; inhibits the growth of DU145, LNCaP, and PC3 prostate cancer, but not RWPE-1 non-cancerous, cells at 2.5, 5, and 10 µM; reduces tumor growth in a PC3 mouse xenograft model at 10, 20, or 50 mg/animal; decreases severity of osteoarthritis-associated histopathological alterations in a mouse model of osteoarthritis at 20 mg/kg
Cayman Chemical GR127935hydrochlorIde 50mg
A 5-HT1B and 5-HT1D receptor antagonist (IC50s = 3.16, 1.26, and 0.13 nM, respectively); selective for the 5-HT1B and 5-HT1D receptors over other 5-HT receptors (IC50s = 39.81->10,000 nM in radioligand binding assays); enhances memory consolidation in an autoshaping learning task in rats when administered post-training at 10 mg/kg; has been used to elucidate the 5-HT receptor subtypes involved in the anti-inflammatory activity of sumatriptan
Cayman Chemical MItraphylIn 50mg
An alkaloid with anti-inflammatory and antiproliferative properties; reduces production of NO, IL-8, IL-6, and TNF-α as well as expression of iNOS in LPS-activated human neutrophils; inhibits the growth of SKN-BE(2) neuroblastoma, GAMG glioblastoma, MHH-ES-1 Ewing's sarcoma, and MT-3 breast cancer cells (IC50s = 12.3, 20, 17.15, and 11.18 μM, respectively); inhibits LPS-induced release of IL-1α, IL-1β, IL-17, and TNF-α in mouse serum at 30 mg/kg per day
Cayman Chemical PrenylamIn 100mg
A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg