Human Sera
Cayman Chemical RS 25344 (hydrochloride), Purity: ≥95%, CAS: 152815-28-6, 50 mg
A PDE4 inhibitor (IC50 = 0.3 nM); selective for PDE4 over PDE1, -2, and -3 (IC50s = >100 µM for all); inhibits concanavalin A-induced IL-5 release and LPS-induced TNF-α release in isolated human PBMCs (EC50s = 0.3 and 5.4 nM, respectively)
Cayman Chemical 7α-hydroxy-3-oxo-5β-Cholan-24-oic Acid, Purity: ≥95%, CAS: 4185-00-6, 50 mg
A metabolite of chenodeoxycholic acid; formed from chenodeoxycholic acid primarily by CYP3A4 but also by CYP3A5 and other P450 enzymes at lower rates
Cayman Chemical 11β-hydroxy Testosterone, Purity: ≥95%, CAS: 1816-85-9, 50 mg
A metabolite of testosterone
Cayman Chemical 3-Methylbuphedrone (hydrochloride), Purity: ≥98%, CAS: 1797911-07-9, 50 mg
A methylated analog of buphedrone; intended for forensic and research applications
Cayman Chemical 3′-Deoxy-3′-fluorothymidine, Purity: ≥98%, CAS: 25526-93-6, 50 mg
A nucleoside analog; a TK1 substrate; inhibits TK1 and TK2 (Kis = 6 and 10 µM, respectively); inhibits HIV-1 reverse transcriptase (EC50 = 5 nM) and the replication of HIV-1 in MT-4 cells (EC50 = 5 nM); decreases mtDNA levels and the OCR and induces upregulation of CD11b in OCI-AML-2 and MV4-11 cells; reduces tumor growth in an OCI-AML-2 AML mouse xenograft model at 50 mg/kg; a radiolabeled form is commonly used as a PET tracer for in vivo imaging of tumors
Cayman Chemical Deoxypodophyllotoxin, Purity: ≥95%, CAS: 19186-35-7, 100 mg
A flavolignan with diverse biological activities; inhibits tubulin polymerization in a cell-free assay at 50 nM; inhibits COX-2 and 5-LO in isolated mouse bone marrow-derived mast cells stimulated with KL, IL-10, and LPS (IC50s = 1.89 and 0.37 µM, respectively); reduces viral yield in the supernatant of HSV-1- or HSV-2-infected MRC-5 cells at 0.02 µg/ml; inhibits aggregation of rabbit platelets induced by PAF, collagen, or arachidonic acid; induces mortality in P. rapae fifth instar larvae (LC50 = 0.02 g/L); reduces tumor growth in a CT26 murine colon cancer model at 70 µg/kg
Cayman Chemical Nα-Benzoyl-L-Arginine-pNA (hydrochloride), Purity: ≥98%, CAS: 21653-40-7, 100 mg
A colorimetric substrate for trypsin and papain; enzymatic cleavage releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of trypsin or papain activity
Cayman Chemical Ricinelaidic Acid, Purity: ≥95%, CAS: 540-12-5, 100 mg
An LTB4 receptor antagonist (Ki = 2 µM); inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s = 10 and 7 µM, respectively); inhibits bronchoconstriction induced by LTB4 in rats by 46%
Cayman Chemical D2PM (hydrochloride), Purity: ≥98%, CAS: 172152-19-1, 50 mg
A psychoactive designer drug; also used in organic synthesis to prepare the Corey-Bakshi-Shibata catalyst; intended for forensic purposes
Cayman Chemical C4 Ceramide (d18:1/4:0), Purity: ≥95%, CAS: 74713-58-9, 50 mg
A bioactive sphingolipid; inhibits IL-4 production by 16% in PMA-stimulated EL4 T cells at 10 μM; cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively); increases maturation and stability of F508del-CFTR proteins, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis
Cayman Chemical Scopolamine, Purity: ≥98%, CAS: 51-34-3, 100 mg
An alkaloid with diverse biological activities; an antagonist of mAChRs (Kis = 0.19, 1.41, and 0.18 nM for the rat M1, M2, and M3 receptors, respectively); reduces acetylcholine-induced contractions in isolated guinea pig ileum (IC50 = 8.1 nM); inhibits oxotremorine-induced tremors in mice (ED50 = 0.23 mg/kg); increases fine motor activity counts and ambulatory activity in rats in a home-cage activity test (ED50 = 0.12 mg/kg for both); has been used to induce learning deficiencies or amnesia in animal models
Cayman Chemical L-Lysine lactam (hydrochloride), Purity: ≥95%, CAS: 26081-07-2, 100 mg
A building block; has been used in the synthesis of HIV protease inhibitors, as well as bengamide derivatives with in vitro anticancer activity
Cayman Chemical 5'-(N-Cyclopropyl)carboxamidoadenosine, Purity: ≥95%, CAS: 50908-62-8, 50 mg
A specific adenosine A2 receptor agonist with antipyretic and anticonvulsant activity; stimulates the production of cyclic AMP in CHO-K1 cells with an EC50 value of 5.3 µM
Cayman Chemical 3-Acetylmorphine, Purity: ≥98%, CAS: 5140-28-3, 50 mg
A less active metabolite of heroin with relatively weak affinity for µ-opioid receptors; intended only for forensic and research purposes
Cayman Chemical 3,4-Methylenedioxy-N-benzylcathinone (hydrochloride), Purity: ≥98%, CAS: 1823274-68-5, 50 mg
A substituted cathinone that is structurally analogous to methylone, a narcotic which is regulated in the United States; intended for research and forensic applications