Human Sera
Cayman Chemical Aunt fumatuus NomIln 50mg
A limonoid triterpenoid; reduces HIV-1 replication in infected PBMCs (EC50 = 52.2 μM); dose-dependently reduces HUVEC proliferation, invasion, tube formation, and MMP-2 and MMP-9 activity at 5-25 μg/ml; increases GST activity in small intestinal mucosa, liver, and forestomach homogenates of mice by 4.17-, 3.44-, and 1.16-fold, respectively, at 10 mg; increases TGR5-dependent luciferase activity 5.5-fold in HEK293 cells at 100 μM; completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet at 0.2%; increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells at 10 μmol/kg
Cayman Chemical Pregnolon sulfatesodIum 100mg
A metabolite of pregnenolone that modulates NMDA receptor responses to exogenously applied glutamate and stimulates TRPM3
Cayman Chemical 14-PentadecenoIc AcId 100mg
A 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail
Cayman Chemical Tafenoqun 50mg
An antimalarial agent; active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml); inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice at 25 or 50 mg/kg; suppresses parasitemia in a hamster model of B. microti infection from 3.25-52 mg/kg
Cayman Chemical IsotretInoIn 50mg
A retinoid; increases the doubling time and transcription of RARβ mRNA in various human oral squamous cell carcinoma cells at 1 μM; inhibits proliferation of primary human sebocytes (IC50 = 10 μM); decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at 0.1 μM; reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice at 2 mg/kg per day; slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration at 40 mg/kg
Cayman Chemical FosInoprIlsodIum salt 100mg
A prodrug form of fosinoprilat; inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys at 15, 15, and 10 µmol/kg, respectively; reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure at 2.5 mg/kg
Cayman Chemical ArachIdIc AcIdodIum salt 100mg
A long-chain saturated fatty acid; inhibits fMLP-induced rabbit neutrophil aggregation at 5 μM
Cayman Chemical N2Isobutyryl5O 4 4dIme 100mg
A building block; has been used in the synthesis of oligodeoxyribonucleotides
Cayman Chemical RocuronIumbromIde 50mg
A non-depolarizing muscle relaxant; selectively induces neuromuscular blockade in cats (ED50s = 153, 185, 1,329, and 4,119 μg/kg for tibialis, soleus, and vagus muscles, and nictitating membranes, respectively; has a more rapid onset time than vecuronium
Cayman Chemical AtrasentnhydrochlorIde 50mg
An ETA antagonist (Ki = 69 pM for the human receptor); selective for ETA over ETB (Ki = 139 nM for the human receptor) and a panel of 29 other receptors at 10 µM; inhibits endothelin-1-induced secretion of arachidonic acid from HPSMCs (pA2 = 10.5), as well as endothelin-1-induced vasoconstriction in isolated rat aortic rings (pA2 = 9.2); inhibits endothelin-1-induced increases in the pressor response in normotensive rats at 10 mg/kg; reduces urinary levels of albumin, TGF-β, and a PGE2 metabolite, as well as decreases the number of macrophages, in a rat model of streptozotocin-induced diabetic nephropathy at 5 mg/kg per day
Cayman Chemical Paclobutrazol 100mg
A triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins
Cayman Chemical DeslorelInacetate 50mg
A peptide agonist of GnRH; binds to GnRHR (Ki = 0.1 nM); decreases testicular volume, semen volume, sperm motility, and total sperm count, as well as increases the percentage of abnormal sperm, in dogs via a subcutaneous implant at 3, 6, and 12 mg per animal; decreases disease severity and plasma levels of estradiol, 17-hydroxyprogesterone, and androstenedione in ferrets with ACD at 3 mg/implant per animal; suppresses ovulation and estrus in cats at 4.7 mg/implant per animal
Cayman Chemical Mornteltartrate 100mg
A positive allosteric modulator of nAChRs; enhances channel gating of the α3β2 nAChR subtype
Cayman Chemical Flumethason 50mg
An agonist of glucocorticoid and mineralocorticoid receptors (EC50s = 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors); inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines (100 nM); decreases TNF production ex vivo in blood cells collected by BAL from calves with experimentally-induced local lung inflammation (5 mg per animal); impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in vivo in zebrafish (5 μM)