Human Sera
Cayman Chemical 5Cyno2 3dI ptolyltetra 50mg
A redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms; readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal (absorption maximum at 450 nm)
Cayman Chemical 4ChLRomethamphetamInhydr 50mg
A halogenated analog of methamphetamine; converted to 4-chloroamphetamine in vivo
Cayman Chemical GaboxadolhydrochlorIde 50mg
A GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)); acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).
Cayman Chemical Frtlara thunberg Pemn 50mg
An alkaloid with diverse biological activities; an inhibitor of Nav1.7 (IC50= 47.2 µM) and hERG (IC50 = 43.7 µM); increases the latent period of coughs, decreases the number of coughs, and has expectorant activity in a mouse model of ammonia liquor-induced cough at 3 mg/kg; inhibits the growth of DU145, LNCaP, and PC3 prostate cancer, but not RWPE-1 non-cancerous, cells at 2.5, 5, and 10 µM; reduces tumor growth in a PC3 mouse xenograft model at 10, 20, or 50 mg/animal; decreases severity of osteoarthritis-associated histopathological alterations in a mouse model of osteoarthritis at 20 mg/kg
Cayman Chemical ClothInIdIn 50mg
A neonicotinoid insecticide and an active metabolite of thiamethoxam; binds to nAChRs (IC50 = 0.6 nM for housefly head membranes); activates non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = 1,520 nM); induces mortality in adult M. persicae (LC95 = 1.28 mg/L), as well as H. virescens and S. frugiperda second instar larvae at 8 mg/L in a leaf-dip bioassay; increases the number of premature births in rabbits at >25 mg/kg; reduces the length and weight of fathead minnows when administered in tank water at 20 mg/L
Cayman Chemical SItravatInIb 50mg
A multi-kinase inhibitor; inhibits 35 kinases (IC50s = 0.5-4,098 nM) in a panel of 55 RTKs; reduces proliferation in various cancer cells (IC50s = 340.1-1,830 nM) and decreases phosphorylation of IGF1-R, PDGFRβ, and Akt at 62.5-4,000 nM; decreases tumor growth in LPS141 and MPNST mouse xenograft models at 15 mg/kg per day
Cayman Chemical DorzolamIdehydrochlorIde 100mg
A carbonic anhydrase inhibitor (Kis = 3.5-52 nM for carbonic anhydrase II, V, VI, IX, XII, XIII, and XIV) that is selective for these isoforms over carbonic anhydrase I, III, and IV (Kis = 50, 8, and 8.5 µM, respectively); inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% at 0.02%; reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits at 0.5%, applied topically
Cayman Chemical RhodamIn B IsothIocynatem 50mg
A cell-permeant fluorogenic dye used as a conjugate to antibodies and proteins for fluorescence detection in microscopy; ex/em max = 570/595 nm; used as an anterograde and retrograde tracer; used in nanoparticles to detect apoptosis
Cayman Chemical Exatecnmesylate 50mg
A DNA topoisomerase I inhibitor (IC50 = 0.975 UG/ml); inhibits cell growth in a panel of 32 breast, colon, stomach, and lung cancer cell lines (GI50s = 0.125-10.4 ng/ml); reduces tumor growth in an SC-6-JCK gastric adenocarcinoma mouse xenograft model from 3.325-50 mg/kg; reduces tumor weight in HCT116, PC-6, and PC12 mouse xenograft models at 75 mg/kg; has been used in the synthesis of cytotoxic payload moieties of ADCs
Cayman Chemical ttramthyl NordIhydroguaIr 50mg
A derivative of nordihydroguaiaretic acid; inhibits Tat-regulated HIV promoter transactivation in COS-1 cells in a reporter assay (IC50 = 11 µM); inhibits replication of acyclovir-sensitive and -resistant strains of HSV-1 in Vero cells (IC50s = 5.6 and 8.9 µM, respectively); induces cell cycle arrest at the G1/G0 phase in A375 cells at 50 µM; inhibits tumor growth in an A375 mouse xenograft model at 250 mg/kg; inhibits tumor growth in a B16 murine melanoma model at 166 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Human Serum from human mal
serum Human Serum from human mal
Cayman Chemical 3Hydroxy4methyl2 5HthIo 50mg
A degradation product of cefaclor; formed under aqueous acidic conditions
Cayman Chemical DeoxypodophylotoxIn 100mg
A flavolignan with diverse biological activities; inhibits tubulin polymerization in a cell-free assay at 50 nM; inhibits COX-2 and 5-LO in isolated mouse bone marrow-derived mast cells stimulated with KL, IL-10, and LPS (IC50s = 1.89 and 0.37 µM, respectively); reduces viral yield in the supernatant of HSV-1- or HSV-2-infected MRC-5 cells at 0.02 UG/ml; inhibits aggregation of rabbit platelets induced by PAF, collagen, or arachidonic acid; induces mortality in P. rapae fifth instar larvae (LC50 = 0.02 g/L); reduces tumor growth in a CT26 murine colon cancer model at 70 UG/kg
Cayman Chemical CarbutamIde 100mg
A first generation sulfonylurea; inhibits KATP channels in β-cells (IC50 = 173 µM); reduces blood glucose levels in anesthetized dogs at 50 mg/kg; increases ventricular fibrillation in a rat model of LAD coronary artery ligation-induced cardiac ischemia