Human Sera
Cayman Chemical UTPsodIum salt 100mg
A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM); stimulates proliferation of PANC-1 cells (EC50 = 13.1 μM), an effect that can be prevented by siRNA against the P2Y2 receptor; induces vasoconstriction in perfused isolated canine epicardial coronary artery; formed from UMP and can be converted to CTP; reacts with glucose-1-phosphate to form UDP-glucose
Cayman Chemical MescalIn NBOMehydrochLRId 50mg
A derivative of mescaline having an N-(2-methoxybenzyl) addition at the amine
Cayman Chemical 2 3Pentylon Isomerhydroch 50mg
A structural isomer of pentylone, having the methylenedioxy group attached at carbons 2 and 3 of the terminal phenyl group; intended for forensic and research applications
Cayman Chemical INCB 3284dImesylate 50mg
A potent, selective, and orally bioavailable antagonist of MCP-1 binding to CCR2 (IC50 = 3.7 nM); inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees
Sigma Aldrich Fine Chemicals Biosciences Human Serum from human male AB plasma, USA origin, sterile-filtered, MFCD00165829
Human Serum from human male AB plasma, USA origin, sterile-filtered
Sigma Aldrich Fine Chemicals Biosciences Human Serum Heat Inactivated (from male AB clotted whole blood), USA origin, sterile-filtered, MFCD00165829
Human Serum Heat Inactivated (from male AB clotted whole blood), USA origin, sterile-filtered
Cayman Chemical 1R 3S3AmInocyclopentnol 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical Gncclovr 50mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical Capsacn 100mg
A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated mouse peritoneal macrophages at 10 and 50 µM; induces substance P release in rat spinal cord slices (EC50 = 2.3 µM); reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.)
Cayman Chemical MIltefosIn 100mg
An inhibitor of CCT; inhibits liposome-induced CCT activity in MDCK cell homogenates from 10-50 µM, as well as induces translocation of CCT from the cell membrane to the cytosol in MDCK cells; inhibits PMA-induced phosphatidylcholine biosynthesis in MDCK and HeLa cells at 50 µM; inhibits phosphatidylserine-activated PKC (IC50 = 62 µM), as well as PMA-induced morphological changes and proliferation of MDCK cells; active against clinical isolate promastigotes of L. infantum (EC50s = 5-25 µM); topical application completely eradicates L. amazonensis and induces re-epithelialization of lesions in a mouse model of cutaneous leishmaniasis at 0.5%
Cayman Chemical nastrozole 100mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical Latnoprost Lacton DIol 50mg
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost lactone diol is an intermediate in the synthesis of latanoprost. Latanoprost lactone diol can be converted to the free acid of latanoprost by reduction with DIBAL followed by Wittig reaction with commercially available reagents.
Cayman Chemical DeltamethrIn 50mg
A type II pyrethroid insecticide and Nav channel modulator; activates Nav1.8 channels and induces a tail current delay in Xenopus oocytes expressing the rat channel at 10 µM; induces mortality in A. sinensis (LC50 = 4.522 ppm) and T. urticae (LC50 = 0.06 g/L); decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats at 5 mg/kg
Cayman Chemical TIrapazamIn 100mg
A hypoxia-activated anticancer agent; is converted to an oxidizing radical under hypoxic conditions; can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity; induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively); induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions; sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model; sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model at (0.08 mmol/kg)