Human Sera
Cayman Chemical DProPheArgpNAhydrochlor 50mg
A colorimetric plasma kallikrein substrate; cleavage of the PFR peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of plasma kallikrein activity
Cayman Chemical VIloxazInhydrochlorIde 100mg
An antidepressant; selectively inhibits norepinephrine uptake over 5-HT uptake in rat hypothalamic synaptosomes (IC50s = 0.9 and >100 µM, respectively); decreases immobility time in the forced swim test in mice at 8 and 16 mg/kg
Cayman Chemical SureLIghtPerCP CynIn 5 5 50mg
SureLight™ PerCP Cyanine 5.5 is a fluorescent probe used in protein detection Excitation max. λ: 496 nm Emission max. λ: 517 nm Uses: Custom antibody labeling, fluorescence-activated cell sorting, flow cytometry, Luminex, and T cell labeling
Cayman Chemical 5-AzacytIdIn 100mg
An inhibitor of DNA methyltransferases that reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines)
Cayman Chemical 4methoxyaPyrroldInopentIo 50mg
Shares structural features with the stimulant α-PVP, whose mechanism of action is unknown but is believed to act similarly to the designer drug MDPV
Cayman Chemical BU 224hydrochlorIde 50mg
An imidazoline receptor agonist; selectively binds to imidazoline I1 and -I2 receptors over a2-ARs (IC50s = 0.034, 0.026, and 15 µM, respectively); reduces complete Freund’s adjuvant-induced thermal and mechanical hyperalgesia in rats at 10 or 17.8 mg/kg; decreases the latency to seizure onset and increases the percentage of animals with grade V seizures to a greater extent in female than male mice; reverses cognitive deficits in the 5XFAD transgenic mouse model of Alzheimer’s disease at 5 mg/kg
Cayman Chemical 5bromo3IndolylDGalacto 100mg
A chromogenic substrate for β-galactosidase; upon enzymatic hydrolysis, it generates an indigo-colored precipitate that can be used to measure β-galactosidase activity; has been used to detect β-galactosidase in muscle from E. coli lacZ-expressing transgenic mice
Cayman Chemical GastrodIa elta Gastrodn 50mg
A phenolic glycoside with diverse biological activities; reduces Aβ42-induced cell death of rat hippocampal neurons and BV-2 mouse microglia; improves learning and memory in various transgenic mouse models of Alzheimer's disease; reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease; reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures from 50-200 mg/kg; increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala in a mouse model of valproic acid-induced autistic-like phenotypes at 100 mg/kg; increases biomechanical bone strength in a rat model of dexamethasone-induced osteoporosis; inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease
Cayman Chemical Linolenic ACD 100mg
γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Cayman Chemical -O-Desmethyl VenlafaxIn 50mg
An active metabolite of venlafaxine; inhibits NET and SERT (IC50s = 47.3 and 531.3 nM, respectively); selective for NET and SERT over 50 non-transporter targets; increases extracellular NE in the male rat hypothalamus and 5-HT in the same region when used in combination with WAY-100635; reduces immobility time in the forced swim test in a rat model of cognitive deficits and depression induced by MI when compared with MI-vehicle control animals 16 weeks following MI; improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI
Cayman Chemical NDemethylvncomycInhydroch 50mg
A glycopeptide antibiotic; active against several strains of S. aureus and S. epidermidis in vitro and in vivo
Cayman Chemical SRT 3025hydrochlorIde 100mg
A SIRT1 activator; increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse BMDMs at 2 µM; inhibits proliferation of SU.86.86 cells (IC50 = 0.98 µM); decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet at 3.18 g/kg
Cayman Chemical BuformInhydrochlorIde 100mg
A biguanide that exhibits antihyperglycemic activity by increasing glucose utilization and inhibiting hepatic gluconeogenesis; inhibits the mitochondrial respiratory complex I and the mitochondrial ATP synthase; disrupts the unfolded protein response transcription program during glucose deprivation, inducing cell death in glucose-deprived tumor cells
Cayman Chemical Eprosartnmesylate 50mg
A competitive AT1 receptor antagonist (IC50s 1.4 – 3.9 nM and an elimination half-life of 5 to 7 hours) that blocks angiotensin II receptors on both sympathetic nerve terminals and blood vessels