Human Sera
Cayman Chemical IsoquercetIn 50mg
A mycotoxin with broad spectrum antibiotic activity against Gram positive and Gram negative bacteria acted synergistically at 4-16 mg/L in vitro with erythromycin (500-2000 mg/L) against multi-drug resistant strains of S. aureus reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma
Cayman Chemical AlIzaprIdehydrochlorIde 100mg
A photolabile H -donor used in fluorescence imaging releases acid when excited at 405 nm has been used for fluorescence imaging in conjunction with pH sensitive fluorescent probe cSNARF1 to study nuclear proton dynamics acid venting from cancer cells and hemoglobin-restricted diffusion in the cytoplasm of red blood cells has been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa
Cayman Chemical 10 ZPentadeceNIc ACD mth 50mg
A -opioid receptor antagonist (Ki 0.47 nM) selective over the K- and -opioid receptors (Kis 100 nM and 12 nM respectively) inhibits -opioid receptor-mediated GTP binding to CHO cell membranes (IC50 1.7 nM) inhibits morphine-induced slowing of colorectal transit in mice with (ED50 0.41 mg/kg) reduces morphine-induced inhibition of GI transit in rats at 0.3 and 1 mg/kg p.o.
Cayman Chemical BuclIzInhydrochlorIde 100mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids intended for research and forensic applications
Cayman Chemical AlIzaprIdehydrochlorIde 50mg
A terpene alcohol with diverse biological activities an insecticide that induces 100 mortality of C. maculatus at 16 Ul in an alimentary substrate (LD50 0.714 Ul) no adverse effects in rats at 10000 ppm in the diet for 16 weeks prevents lipid peroxidation increases the levels of GSH the activity of various antioxidant enzymes and the levels of cytokines in a mouse skin model of TPA-induced oxidative stress and inflammation at a topical dose of 250 Ug inhibits HMG-CoA reductase and reduces lipogenesis in a hamster model of hyperlipidemia induced by an atherogenic diet at 100 mg/kg induces apoptosis in and decreases viability of COLO 205 cancer cells (IC50 20 UM)
Cayman Chemical Curcuma zdoara Curcumol 100mg
An antibiotic reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner when administered at doses ranging from 25-100 mg/kg prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection
Cayman Chemical R-CetIrIzInhydrochlorIde 50mg
A long-acting B2-AR agonist with bronchodilator actions inhibits TGF-a-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 15 nM) dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria respectively isolated from guinea pig (pD2s 6.4 7.08 and 6.61 respectively)
Cayman Chemical ButyrylLcarnItInchlorIde 100mg
An antagonist of muscle-type nAChRs (IC50 14.8 nM) acts as a non-depolarizing neuromuscular blocking agent enhances isoflurane anesthesia (ED50 1.62 Ug/kg to reduce immobilization)
Cayman Chemical 11-HexadecenoIc AcId 50mg
An internal standard for the quantification of C18 ceramide by GC- or LC-MS
Cayman Chemical Tocopherol 50mg
A non-competitive allosteric inhibitor of IL-8/CXCL8 activation of CXCR1 and CXCR2 chemokine receptors (IC50s 1 and 100 nM respectively) blocks IL-8-induced leukocyte recruitment (IC50 1 nM) and other inflammatory responses without affecting receptor activation induced by other CXCR1 and CXCR2 agonists at 100 nM depletes a cancer stem cell population in human breast cancer cell lines in vitro
Cayman Chemical LysylysylysIntrIfluoroac 100mg
A bufadienolide with cytotoxic and immunomodulatory activities induces cell cycle arrest at the G1 phase and apoptosis in Hep3B cells from 0 13-1 13 UM reduces autoantibody production serum levels of TNF-a IL-1B IFN-Y IL-22 and IL-17 and the number of splenic and lymph node Th17 cells as well as increases saliva flow rates in a mouse model of experimental Sj rgrens syndrome at 100 Ug/kg induces lethality in anesthetized dogs (LD50 0 36 mg/kg)
Cayman Chemical OrnIpresInacetate 50mg
An antiarrhythmic agent inhibits acetylcholine or adenosine-induced potassium currents in isolated guinea pig atrial myocytes (IC50s 0 82 and 0 57 UM respectively) activates or inhibits hERG in a voltage-dependent manner activates KCa1 1/BKCa channels in HEK293 cells expressing Slo1 (EC50 20 2 UM) prolongs the duration of electrically stimulated action potentials in guinea pig papillary muscle ex vivo at 40 mg/kg a TRa and TRB antagonist (IC50s 2 2 and 4 1 UM respectively in reporter assays)
Cayman Chemical 3 3Hydroxyphenyl3hydroxy 50mg
An adenosine A1 receptor antagonist and active metabolite of theobromine and caffeine inhibits binding of cyclohexyladensoine in rat cerebral cortical membranes inhibits eye elongation and reduces decreases in the diameter of scleral collagen fibrils in a guinea pig model of form-deprivation myopia at 300 mg/kg
Cayman Chemical LumogalIon 100mg
Source Active recombinant human C-terminal His-tagged SIRPa expressed in HEK293 cells Amino acids 31-370 MW 39 kDa
Cayman Chemical LIthospermosIde 50mg
A pentacyclic triterpenoid reduces HIV-1 replication in MT-2 cells (IC50 4 1 UM) inhibits cadmium-induced cytotoxicity in HepG2 cells in a concentration-dependent manner