Human Sera
Cayman Chemical VecuronIumbromIde 50mg
A non-depolarizing muscle relaxant that competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis
Cayman Chemical SKF 38393hydrobromIde 50mg
A partial agonist of the dopamine D1-like receptors D1 and D5 (Kis = 1 and ~0.5 nM, respectively)
Cayman Chemical Parbendazole 50mg
An inhibitor of microtubule assembly (EC50 = 3 µM); reduces viability of HeLa cells (EC50 = 0.53 µM); induces genotoxic stress in a reporter assay using HEK293 cells; reduces, but does not eradicate, worm burden in goats with naturally acquired or experimental nematode infections at 15 mg/kg; teratogenic to lamb embryos when administered to pregnant ewes at 60 mg/kg during the third week of pregnancy
Cayman Chemical 2MethylamIno1phenylbutn 50mg
A methamphetamine analog with structural similarity to 2-ethylamino-1-phenylbutane; intended for forensic and research applications
Cayman Chemical 2-methoxy Estron 50mg
An active metabolite of estrone; inhibits proliferation of isolated bovine brain-derived capillary endothelial cells (IC50 = 11.5 µM); increases levels of 6-keto PGF1α in HUVECs at 0.001, 0.01, and 0.1 µM; reduces ovariectomy-induced increases in serum cholesterol in rats at 0.5 mg/kg
Cayman Chemical SID 3712249 50mg
An inhibitor of miR-544 biogenesis; increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, HIF-1α, and ATM in MDA-MB-231, MCF-7, and MCF-10A cells under hypoxic conditions at 20 nM; induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner at 20 nM; enhances the senstivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to 5-FU-induced decreases in cell viability at 20 nM; reduces tumor growth in an MDA-MB-231 mouse xenograft model
Cayman Chemical PalIfosfamIde 50mg
An active metabolite of ifosfamide; formed through hydroxylation of ifosfamide by various hepatic CYP isoforms; cytotoxic to L1210 and CCRF-CEM cancer cells at 100 µM; reduces tumor growth in Lewis lung carcinoma and L1210 leukemia mouse models, as well as a rat Yoshida ascitic sarcoma model at 100 mg/kg per da
Cayman Chemical 1S 3R3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical Hydroxy DImetrIdazole 100mg
A metabolite of dimetridazole, the nitroimidazole-based antibacterial and anticoccidial agent suspected to be carcinogenic and mutagenic to humans
Cayman Chemical R-CetIrIzInhydrochlorIde 50mg
A selective histamine H1 receptor antagonist; the (R)-enantiomer of cetirizine; binds to the H1 receptor with higher affinity than cetirizine (Kis = 3 and 6 nM, respectively) and is highly selective for H1 over M1-M5 receptors; decreases production of RANTES and eotaxin following antigen stimulation in mouse eosinophils in vitro (MEC = 0.05 µM); dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice (0.01-1% solution)
Cayman Chemical DIhomoLInolenIc ACD ethyl 50mg
An ester form of DGLA; dietary administration of ethyl DGLA at 1 g/kg per day increases PGE1 and PGE2 secretion in rabbit renal papilla; increases triglyceride levels and the proportion of 20:3ω6 and 20:4ω6 phospholipids of the renal medulla in rabbits
Cayman Chemical Lnnamvr 50mg
An inhibitor of influenza neuraminidases and an active metabolite of laninamivir octanoate; inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 2.49, 11.4, and 16.7 nM, respectively) and influenza B Victoria and Yamagata strains (mean IC50s = 18.9 nM for both); increases survival in a mouse model of lethal influenza H1N1 infection when administered intranasally at 69 UG/kg
Cayman Chemical PhentolamInmesylate 100mg
A reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities; rapidly and transiently increases local blood flow
Cayman Chemical ngelIs Salt 100mg
A classical nitroxyl (NO-) donor; dissociates in a pH-dependent, first order process with a half-life of 2.3 minutes at 37°C, pH 7.4, to liberate 0.54 moles for NO per mole of parent compound