Guinea Pig Whole Blood
Cayman Chemical compre Faty ACD Meth 1mL
A dual inhibitor of PI3K and mTOR (IC50s 3 4 12 16 and 16 nM for PI3Ka PI3KB PI3K and PI3KY respectively) inhibits proliferation of PC3 and MCF-7 1 cells (IC50s 330 and 180 nM respectively) reduces tumor volume in PC3 and MCF-7 1 mouse xenograft models at 10 mg/kg per day
Cayman Chemical 3AmInopropylphosphonIc ACD
A chromone complex that acts as a mast cell stabilizer to prevent the release of histamine
Cayman Chemical 3AmInopropylphosphonIc ACD
A chromone complex that acts as a mast cell stabilizer to prevent the release of histamine
Cayman Chemical DocosahexaenoIc ACD Alkyn
A long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture included in media to enhance the survival of human embryonic stem cells or drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells
Cayman Chemical ArachIdonIc ACD 1 2 3 4 513
A pan Akt inhibitor (Ki 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Cayman Chemical 8 Z 14 ZEIcosadIenoIc ACD
A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling particularly through disulfide linkages with cysteine residues on proteins
Cayman Chemical 3AmIno5hydroxybenzoIc ACD
A flavonolignan with diverse biological activities inhibits MCT8 (IC50 100 nM) and MCT8-dependent uptake of T3 in MDCK cells and primary mouse astrocytes (IC50s 170 and 50 nM respectively) scavenges DPPH radicals in a cell-free assay (IC50 18 97 UM) inhibits tert-butyl-induced lipid peroxidation in rat liver microsomes (IC50 5 45 UM) inhibits P-gp in P-gp-containing membranes (IC50 21 UM) and LPS-induced production of NO in RAW 264 7 cells (IC50 65 UM)
Cayman Chemical NordIhydroguaIaretIc ACD 500mg
An inhibitor of FAP (IC50 3.2 nM) selective for FAP over prolyl endopeptidase DPP-4 DPP-9 and DPP-2 (IC50s >1.8 >100 >12.5 and >100 UM respectively)
Cayman Chemical 3 3SulfInyldIpropnoIc ACD
A peptide substrate for PKC selective for PKC over PKA CK1 CK2 phosphorylase kinase and CaMKII has been used to monitor PKC activity in primary human renal artery smooth muscle cells
Cayman Chemical 4HydroxyphenylglyoxylIc ACD
A dual inhibitor of p70S6K and Akt1 (IC50s 1.1 and 4 nM respectively) selective for p70S6K and Akt1 over Aurora B kinase (IC50 170 nM) as well as a panel of 265 kinases at 1 UM inhibits PKA MSK1 MSK2 PKG1a PKG1B and PRKX reduces tumor volume in A549 and MiaPaCa-2 mouse xenograft models at doses of 20 or 30 mg/kg respectively
Cayman Chemical ProstatIc ACD Phosphatsem
A peptide antagonist of PAR4 inhibits platelet aggregation induced by AYPGKF-NH2 in washed isolated rat platelets (IC50 95-190 UM) induces relaxation of isolated rat aortic rings precontracted with phenylephrine and contraction of isolated rat gastric longitudinal muscle strips (EC50s 64 and 1 UM respectively) inhibits thrombin-induced migration of primary HCC cells at 400 UM reduces myocardial infarct size as a percentage of the area at risk ex vivo in an isolated rat heart model of ischemia-reperfusion injury
Sigma Aldrich Fine Chemicals Biosciences Alsevers Solution liqids500ML
Alsevers SOLUTIONon liqids500ML
Cayman Chemical 7 12DIketolIthocholIc ACD
A carotenoid with hepatoprotective activity inhibits TGF-b-induced activation of hepatic stellate cells (IC50 186.34 UM) reduces hepatic collagen deposition and TBARS levels as well as serum AST and ALP activity in a rat model of bile duct ligation-induced hepatic fibrosis at 25 mg/kg reduces hepatic steatosis inflammation and fibrosis in a model of NASH induced by a methionine choline-deficient diet in HBV transgenic mice