Protein Phosphorylation Antibody Pairs
Cell Signaling Technology PathScanR RP Phospho-Stat5a Tyr694 Sandwich ELISA Kit 5 Kit
PathScanR RP Phospho-Stat5a Tyr694 Sandwich ELISA Kit 5 Kit
ABclonal Technology CDKN1B/p27KIP1 Rabbit pAb
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 10 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 10 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 50 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 50 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 50 Kit
PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 50 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 10 Kit
PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 10 Kit
ABclonal Technology Phospho-Smad2-S465/S467 Rabbit pAb
This gene encodes a protein in the SMAD family, which transduces signals and regulates transcription in various pathways. It mediates TGF-beta signaling, affecting cell proliferation, apoptosis, and differentiation. The protein interacts with the SMAD anchor for receptor activation (SARA) and is recruited to TGF-beta receptors. Phosphorylation by TGF-beta receptors causes dissociation from SARA and association with SMAD4, allowing translocation to the nucleus. There, it binds to promoters and forms a transcription repressor complex. The protein can also be phosphorylated by activin type 1 receptor kinase to mediate activin signaling. Alternative splicing results in multiple transcript variants.
Cell Signaling Technology Phospho-SMAD2 Ser465467 D20B3 Rabbit mAb BSA and Azide Free 100 ug
Phospho-SMAD2 Ser465467 D20B3 Rabbit mAb BSA and Azide Free 100 ug
Cell Signaling Technology PathScanR RP Phospho-Stat5a Tyr694 Sandwich ELISA Kit 10 Kit
PathScanR RP Phospho-Stat5a Tyr694 Sandwich ELISA Kit 10 Kit
ABclonal Technology Phospho-Smad5-S463/S465 Rabbit pAb
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.
ABclonal Technology p-Smad2/3-S465/S467/S423/S425
The protein encoded by this gene belongs to the SMAD family which includes proteins similar to Drosophila Mad and C elegans Sma SMAD proteins are signal transducers and transcriptional modulators involved in multiple signaling pathways This protein mediates the transforming growth factor (TGF)-beta signal regulating cell processes like proliferation apoptosis and differentiation It is recruited to TGF-beta receptors via its interaction with the SMAD anchor for receptor activation (SARA) protein Phosphorylation by TGF-beta receptors causes dissociation from SARA and association with SMAD4 which is essential for nuclear translocation In the nucleus it binds to target promoters and forms a transcription repressor complex The protein can also be phosphorylated by activin type 1 receptor kinase mediating activin signaling Alternative splicing results in multiple transcript variants
ABclonal Technology p-HDAC4/5/9-S246/S259/S220
Histones play a critical role in transcriptional regulation cell cycle progression and developmental events Histone acetylation deacetylation alters chromosome structure and affects transcription factor access to DNA The protein encoded by this gene belongs to class II of the histone deacetylase acuc apha family It possesses histone deacetylase activity and represses transcription when tethered to a promoter This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D It seems to interact in a multiprotein complex with RbAp48 and HDAC3 [provided by RefSeq Jul 2008]