Protein Phosphorylation Antibody Pairs
Gibco™ Floor Plate Cell Expansion Kit
The Floor Plate Cell Expansion Kit is a component of the Gibco™ PSC Dopaminergic Neuron Differentiation Kit that is also offered separately.
ABclonal Technology Raf1 Rabbit pAb
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
ABclonal Technology Phospho-Camk2-T286 Rabbit mAb
The product of this gene belongs to the serine threonine protein kinases family and to the Ca(2 ) calmodulin-dependent protein kinases subfamily Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses This calcium calmodulin-dependent protein kinase is composed of four different chains alpha beta gamma and delta The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning In addition to its calcium-calmodulin (CaM)-dependent activity this protein can undergo autophosphorylation resulting in CaM-independent activity Several transcript variants encoding distinct isoforms have been identified for this gene
ABclonal Technology Phospho-Camk2-T286 Rabbit mAb
The product of this gene belongs to the serine threonine protein kinases family and to the Ca(2 ) calmodulin-dependent protein kinases subfamily Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses This calcium calmodulin-dependent protein kinase is composed of four different chains alpha beta gamma and delta The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning In addition to its calcium-calmodulin (CaM)-dependent activity this protein can undergo autophosphorylation resulting in CaM-independent activity Several transcript variants encoding distinct isoforms have been identified for this gene
ABclonal Technology Phospho-NF-B p105-S932
This gene encodes a 105 kD protein that is processed by the 26S proteasome into a 50 kD protein The 105 kD protein acts as a Rel protein-specific transcription inhibitor while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB activated by stimuli like cytokines UV irradiation and bacterial or viral products regulates various biological functions Once activated NFKB translocates to the nucleus to stimulate gene expression Inappropriate NFKB activation is linked to inflammatory diseases while its inhibition can disrupt immune cell development and delay cell growth NFKB also regulates the early response to viral infections Alternative splicing generates multiple isoforms including proteolytically processed variants
ABclonal Technology CDKN1B/p27KIP1 Rabbit pAb
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Cell Signaling Technology FastScantm Phospho-SMAD2 Ser465467 ELISA Kit 5 Kit
FastScantm Phospho-SMAD2 Ser465467 ELISA Kit 5 Kit
Meso Scale Discovery Phospho (Tyr694)/Total STAT5a,b Whole Cell Lysate
Phospho (Tyr694)/Total STAT5a,b Whole Cell Lysate
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 50 Kit
PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 50 Kit
ABclonal Technology Phospho-SHC1-Y427 Rabbit pAb
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology Phospho-STK11-S334 Rabbit pAb
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
Cell Signaling Technology PathScanR RP Phospho-Stat5a Tyr694 Sandwich ELISA Kit 50 Kit
PathScanR RP Phospho-Stat5a Tyr694 Sandwich ELISA Kit 50 Kit
ABclonal Technology Phospho-Smad2-T220 Rabbit pAb
This gene encodes a SMAD protein, part of a family involved in signal transduction and transcriptional regulation. It mediates the TGF-beta signaling pathway, regulating processes like cell proliferation, apoptosis, and differentiation. The protein is recruited to TGF-beta receptors via interaction with the SMAD anchor for receptor activation (SARA). Phosphorylation by TGF-beta receptors causes dissociation from SARA and association with SMAD4, enabling nuclear translocation. In the nucleus, the protein binds to target promoters and forms a transcription repressor complex. It can also be phosphorylated by activin receptor kinase, mediating activin signaling. Alternative splice variants of this gene have been observed.
ABclonal Technology Phospho-STK11-T189 Rabbit pAb
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 20 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 20 Kit