Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD40 mAb
This gene is part of the TNF-receptor superfamily encoding a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation It is regulated by the AT-hook transcription factor AKNA which controls both the receptor and its ligand aiding in homotypic cell interactions The receptor interacts with TNFR2 to mediate signal transduction and is essential for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple splice variants encoding different isoforms have been identified
ABclonal Technology APC Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 594 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 450 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology 594 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology 594 Rabbit anti-Human CD97
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors which mediate cell-cell interactions These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit which associate at the cell surface as a receptor complex The encoded protein may play a role in cell adhesion as well as leukocyte recruitment activation and migration and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55 Expression of this gene may play a role in the progression of several types of cancer Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19
ABclonal Technology 488 Rabbit anti-Human CD146
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily protein originally identified as a cell surface adhesion marker for melanoma progression and metastasis It is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells Increased MCAM expression is found in disorders involving angiogenesis such as inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure MCAM-expressing mesenchymal stromal cells (hMSC) maintain hematopoietic stem and progenitor cell (HSPC) self-renewal through direct contact Activation of the Notch pathway may contribute to HSPC maintenance Additionally MCAM is involved in multiple sclerosis where endothelial MCAM in the blood-brain barrier facilitates lymphocyte transmigration and inflammatory lesion formation
ABclonal Technology 647 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants
ABclonal Technology 488 Rabbit anti- CD161c/NK1.1
Enables identical protein binding activity and signaling receptor activity Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity Located in external side of plasma membrane Is integral component of plasma membrane Is expressed in thymus primordium Orthologous to human KLRB1 (killer cell lectin like receptor B1)
Jackson Immuno Research Labs AffiniPure Rabbit Anti-Rat IgG F(ab')2 Fragment Specific (min X Hu Sr Prot)
AffiniPure Rabbit Anti-Rat IgG F(ab')2 Fragment Specific (min X Hu Sr Prot)
Jackson Immuno Research Labs Peroxidase-AffiniPure Rabbit Anti-Rat IgM µ Chain Specific
Peroxidase-AffiniPure Rabbit Anti-Rat IgM µ Chain Specific
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure Rabbit Anti-Rat IgM µ Chain Specific
Alexa Fluor 488-AffiniPure Rabbit Anti-Rat IgM µ Chain Specific
ABclonal Technology PE Rabbit anti-Rat IgG2b Fc
Enables antigen binding activity Acts upstream of or within phagocytosis positive regulation of immune response and positive regulation of phagocytosis Located in extracellular space Part of immunoglobulin complex circulating Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))
ABclonal Technology 647 Rabbit anti-Rat IgG2b Fc
Enables antigen binding activity Acts upstream of or within phagocytosis positive regulation of immune response and positive regulation of phagocytosis Located in extracellular space Part of immunoglobulin complex circulating Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))
ABclonal Technology PE Rabbit anti-Rat IgG mAb
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to act upstream of or within several processes including antibody-dependent cellular cytotoxicity phagocytosis and positive regulation of immune response Predicted to be located in external side of plasma membrane and extracellular space Predicted to be part of immunoglobulin complex circulating Orthologous to human IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))