Rabbit Secondary Antibodies
Cayman Chemical CaveolIn1CTRm RabbIt Mo 100uL
An analytical reference standard that is structurally similar to known synthetic cannabinoids a potential metabolite of 5-fluoro MPP-PICA based on the published metabolism of 5-fluoro AMB-PICA intended for research and forensic applications
ABclonal Technology TRAF4 Rabbit mAb
This gene encodes a member of the TNF receptor associated factor (TRAF) family TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily The encoded protein has been shown to interact with neurotrophin receptor p75 (NTR NTSR1) and negatively regulate NTR induced cell death and NF-kappa B activation This protein has been found to bind to p47phox a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase This protein thus is thought to be involved in the oxidative activation of MAPK8 JNK Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined
Cayman Chemical Grnzyme BCTerm RabbIt Mo 100uL
An androgenically inactive metabolite of testosterone and androstenedione potentiates GABA-induced chloride currents in HEK293 cells expressing rat a1B2Y2L subunit-containing GABAA receptors at 10 UM protective against seizures induced by 6 Hz electroshock or PTZ (ED50s 76 9 and 139 mg/kg respectively) increases body temperature in rhesus macaques
ABclonal Technology APC Rabbit anti-Mouse IL-13
Predicted to enable interleukin-13 receptor binding activity Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation Acts upstream of or within cellular response to cytokine stimulus inflammatory response and positive regulation of immune effector process Located in cytoplasm external side of plasma membrane and extracellular space Is expressed in gut liver male reproductive gland or organ and thymus Used to study atopic dermatitis Human ortholog(s) of this gene implicated in several diseases including allergic disease (multiple) autoimmune disease (multiple) diffuse scleroderma lung disease (multiple) and nose disease (multiple) Orthologous to human IL13 (interleukin 13)
ABclonal Technology Wnt16 Rabbit mAb
The WNT gene family consists of structurally related genes which encode secreted signaling proteins These proteins have been implicated in oncogenesis and in several developmental processes including regulation of cell fate and patterning during embryogenesis This gene is a member of the WNT gene family It contains two transcript variants diverging at the 5 termini These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter They are differentially expressed in normal tissues one of which (variant 2) is expressed at significant levels only in the pancreas whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney placenta brain heart and spleen
Cayman Chemical p53NTerm RabbIt Monclona 100uL
A polyketide active against S. aureus and E. coli in agar diffusion assays at 64 Ug/disc inhibits growth of HM02 KATO III HepG2 and MCF-7 cancer cells (GI50s 0.1 0.7 0.1 and 7.5 Umol/L)
ABclonal Technology OXGR1 / GPR99 Rabbit mAb
This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily The encoded protein is activated by the citric acid intermediate oxoglutarate as well as several cysteinyl leukotrienes including leukotrienes E4 C4 and D4 which are implicated in many inflammatory disorders In mice a knock-out of this gene leads to middle ear inflammation changes in the mucosal epithelium and an increase in fluid behind the eardrum and is associated with hearing loss Alternative splicing results in multiple transcript variants
ABclonal Technology ALDH7A1 Rabbit mAb
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation This particular member has homology to a previously described protein from the green garden pea the 26g pea turgor protein It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix Recent reports show that this protein is found both in the cytosol and the mitochondria and the two forms likely arise from the use of alternative translation initiation sites An additional variant encoding a different isoform has also been found for this gene Mutations in this gene are associated with pyridoxine-dependent epilepsy Several related pseudogenes have also been identified
Cayman Chemical LFA3CD58 RabbIt Monclonal 50uL
An inhibitor of RNA polymerase I-mediated transcription binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells at 10 UM induces apoptosis in A549 and HL-60 cells at 5 UM reduces tumor growth in MDA-MB-231 and MiaPaCa-2 mouse xenograft models at 5 mg/kg
