MW 523.7 Da, Purity >99%. Potent, ATP-competitive fibroblast growth factor receptor 1 (FGFR1) and FGFR3 inhibitor (IC₅₀ values are 21.5 and 5 nM respectively). Shows little activity at EGFR, InsR, MEK and cPKC. Effectively inhibits angiogenesis in vivo. Also impairs tumor growth and inhibits self-renewal of stem cells.
The product is subject to the following: Abcam Restricted Use Statement