Cell Based Assays
Abcam Human RXRA knockout HCT116 cell lysate.
Human RXRA knockout HCT116 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human IKBKB (IKK beta) knockout HeLa cell lysate.
Human IKBKB (IKK beta) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences Z-WEHD-FMK (Ready-to-Use) (20µl)
Inhibitor of caspase-1, -4, -5 and -14. Irreversible, cell permeable inhibitor of caspase-1 and -5. Inhibits also caspase-4 and-14. Designed as a methyl ester to facilitate cell permeability. Alternative name: Caspase 1 inhibitor (fluoromethylketone), Caspase 5 inhibitor (fluoromethylketone). Formula: C37H42FN7O11. MW: 763.8. Purity: ≥99% (HPLC). Formulation: Liquid. In DMSO. Long Term Storage: -20°C.
Apexbio Technology LLC Caspase-3/7 Inhibitor I 220509-74-0 5mg
Caspase-3/7 Inhibitor I (CAS 220509-74-0) is a reversible inhibitor of caspase-3 and caspase-7 structurally belonging to the isatin sulfonamide class It exhibits selective inhibition toward caspase-3 and caspase-7 with Ki values of 60 nM and 170 nM respectively while minimally affecting caspase-9 (Ki 3 1 mM) and showing negligible activity against other caspases (caspases 1 2 4 6 and 8 Ki 25 mM) In cell-based assays this inhibitor effectively reduces apoptosis induced by camptothecin in Jurkat cells (IC50 50 M) and markedly suppresses apoptosis in chondrocytes at similar concentrations The compound is routinely utilized in apoptosis research and may offer therapeutic insights into apoptotic modulation
Abcam Human POR (Cytochrome P450 Reductase) knockout HCT116 cell lysate.
Human POR (Cytochrome P450 Reductase) knockout HCT116 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human ROCK2 knockout HeLa cell lysate.
Human ROCK2 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human VAV2 knockout HeLa cell lysate.
Human VAV2 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Biotium Mitochondrial Marker(MTC02), Biotin conjugate, 0.1mg/mL
This MAb recognizes a 60 kDa antigen associated with the mitochondria in human cells. It is a part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes an antigen associated with the mitochondria in human cells only. It can be used to stain the mitochondria in cell or tissue preparations and can be used as a mitochondrial marker in subcellular fractions. It produces a spaghetti-like pattern in normal and malignant cells and may be used to stain mitochondria of cells in fixed or frozen tissue sections. It can also be used with paraformaldehyde fixed frozen tissue or cell preparations. This MAb is an excellent marker for human cells in xenographic model research. It reacts specifically with human cells, including neurons and embryonic stem cells.Primary antibodies are available purified, or with a s
ABclonal Technology FLCN Rabbit pAb
This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Biotium Apoptosis and Necrosis Quantitation Kit Plus (50 assays)
The Apoptosis and Necrosis Quantitation Kit Plus is a simple, convenient assay for quantifying apoptotic (green; Abs/Em: 490/515 nm) and necrotic (red; Abs/Em with DNA: 528/617 nm) cells within the same cell population by flow cytometry or fluorescence microscopy. Apoptosis is accompanied by phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane. Exposed PS is recognized by Annexin V, a calcium-dependant high-affinity phospholipid-binding protein. CF488A conjugated Annexin V stains apoptotic cells green. CF488A is spectrally similar to fluorescein (FITC), but is brighter and more photostable. Necrosis results from severe cellular injury causing loss of plasma membrane integrity. Ethidium homodimer III (EthD-III), a membrane impermeant high-affinity DNA binding dye stains cells with compromised membranes red. It is superior option to propidium iodide (PI) or ethidium homodimer I due to higher DNA affinity and fluorescence quantum yield.
Medchemexpress LLC Flavokawain C | 37308-75-1 | 20 MG
Flavokawain C is an orally active natural chalcone that inhibits the proliferation of various cancer cells through multiple mechanisms.
- Inhibits cancer cell proliferation
- Upregulates GADD153, p21, and p27
- Modulates Akt and JNK phosphorylation
- Activates caspase subtypes; induces PARP-1 cleavage
- Elevates intracellular ROS; induces apoptosis
- Activates AMPK/mTOR pathway; induces autophagy
- Inhibits glycolysis (decreases GLUT1 and HK2)
- Reduces angiogenesis (decreases Ang-1 and VEGF)
- Increases γ-H2AX levels; induces DNA damage
- Shows anti-tumor activity in mouse xenograft models
Medchemexpress LLC Annexin A1/ANXA1 Mo 1mg
Annexin A1 (ANXA1) Protein, Mouse (His) is a full-length recombinant mouse annexin A1 expressed in Escherichia coli with an N-terminal 6xHis tag, supplied as a lyophilized powder. The protein is >95% pure, has an approximate molecular weight of 40 kDa, and low endotoxin (<1 EU/μg); it is formulated with trehalose for stability and intended for in vitro studies of inflammation, immune signaling, phagocytosis, and chemotaxis.
- Full-length recombinant protein with N-terminal His tag.
- Expressed in Escherichia coli for scalable production.
- Purity greater than 95% by reducing SDS-PAGE.
- Approximately 40 kDa molecular weight.
- Low endotoxin level (<1 EU/μg) suitable for cell-based assays.
- Lyophilized formulation with trehalose for enhanced stability.
- Demonstrated biological activity in suppressing TNF-alpha secretion in RAW264.7 cells.
- Multiple size options available to fit experimental needs.
Abcam Human IFNGR1 knockout HEK-293 cell lysate.
Human IFNGR1 knockout HEK-293 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement