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Bioassays, kits, and reagents used to analyze various properties of living cell samples. Products include apoptosis assays, signal transduction assays, and cell growth and differentiation assays.
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Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney
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An SHP-2 inhibitor (IC50 E76K (IC50 0.17 UM) reduces the levels of phosphorylated ERK in a reporter assay using KYSE-520 cancer cells (IC90 0.012 UM) and inhibits proliferation of the same cells (IC50 0.32 UM) reduces tumor volume in KYSE-520 and NCI H358 mouse xenograft models at 30 or 100 mg/kg two times per day
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GPCR Kinase 3 (GRK3) packaged in BacMam for expression in mammalian cells. Expression is easily titrateable to your experimental needs or to adjust assay sensitivity, enabling rapid assay optimization. Co-express with other Montana Molecular tools includeing GPCRs packaged in BacMam or biosensors for cAMP, DAG, or arrestin signaling.
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A nitroxyl donor reduces MAP and systemic vascular resistance and increases cardiac output in a dog model of microembolism-induced heart failure at four hours post infusion at 7 UG/kg/min for four hours
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The PathHunter Human Siglec9 Stable Cell Line Internalization Assay (U2OS) measures internalization of the Siglec9 receptor via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
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The Tribioscience Urea Colorimetric Assay provides a rapid, sensitive method to measure urea concentration in biological samples. The intensity of the color is directly proportional to the urea concentration in the sample.
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A PROTAC that drives Cdk2 degradation selectively degrades Cdk2 (IC50 24 nM) over seven additional CDKs at 500 nM but also degrades Aurora A kinase and IKZF1 at 250 nM reduces Cdk2 levels and increases the percentage of cells expressing CD11b a marker of differentiation in primary AML cells decreases proliferation without reducing the viability of as well as induces differentiation in primary HSCs
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