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An inhibitor of the gp130-IL-6/IL6Ra protein-protein interaction binds to gp130 (Kd 7.4 UM) and selectively inhibits IL-6-induced STAT3 phosphorylation over leukemia inhibitor factor- or phorbol 12-myristate 13-acetate-induced STAT3 phosphorylation in HepG2 cells at 10 30 or 100 UM reduces IL-6-induced increases in the viability of GM-CSF-starved TF-1 leukemia cells at 10 to 1000 nM inhibits the LPS- and AGE-induced increases in mRNA encoding Rankl as well as inhibits increases in the phosphorylation levels of gp130 Stat3 and Jak2 in mouse MC3T3-E1 osteoblasts at 100 nM decreases joint and paw swelling as well as serum levels of COMP SAP and anti-collagen II antibodies in a mouse model of collagen-induced arthritis at 0.25 mg/kg per day reduces bone resorption height and volume in a rat model of type 2 diabetes peri-implantitis induced by LPS P. gingivalis and a high-fat and high-sUGar diet at 0.23 mg/kg per day p.o.
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A PDE3 inhibitor (IC50 0.4 nM) selective for PDE3 over PDE4 (IC50 1479 nM) reduces the phytohemagglutinin-induced proliferation of isolated human monocytes inhibits LPS-induced increases of TNF-a protein levels in isolated human monocytes (IC50 520 nM) increases cAMP levels in isolated human neutrophils at 10 UM inhibits electric field stimulation-induced contractile responses in isolated guinea pig trachea in a concentration-dependent manner intranasal administration inhibits histamine-induced bronchoconstriction and tracheal edema in guinea pigs at 25 w/w
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A steroidal glycoside with diverse biological activities reduces the proliferation of LNCaP and T47D cancer cells (IC50s 32.1 and 27.5 UM respectively) inhibits TNF-a-induced nuclear translocation of NF-KB in HaCaT keratinocytes at 50 nM decreases AST serum levels in a mouse model of carbon tetrachloride-induced liver injury at 0.1 mg/kg topical administration reduces ear epidermal thickness and scaling as well as leukocyte and macrophage infiltration in an imiquimod-induced mouse model of psoriasis at 5 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More