Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Echelon Biosciences Research Labs 3S-PTDINS(3,4,5)P3 DIC16 500 ug
PtdIns(3,4,5)P3 3-phosphothioate, diC16 (3S-PtdIns(3,4,5)P3, diC16) is a water-soluble, synthetic PI(3,4,5)P3 analog in which the 3-phosphate has been rendered metabolically stable as a phosphorothioate. P-3S908 shows 90% inhibition of PTEN at 0.4M. This item is non returnable
Selleck Chemical LLC 6-Methylcoumarin S4802-25mg
6-Methylcoumarin (Toncarine) a synthetic fragrance widely used in cosmetics belongs to the class of organic compounds known as coumarins and derivatives
Carnabio Usa Inc CK1G1(CSNK1G1)/10UG/FULL-LENGT
CK11(CSNK1G1), Full-length, Wild type, Amino Acid 1-422, NP_071331.2, Expressed in Insect (sf21); 10microg
Apexbio Technology LLC highly selective, potent and cell-permeable p38 MAPK inhibitor 152121-30-7. MFCD00941964
highly selective, potent and cell-permeable p38 MAPK inhibitor 152121-30-7. MFCD00941964
Revvity Health Sciences Inc HTRF cAMP Gs HiRange Detection Kit Standard, 10 Vials
HTRF cAMP Gs HiRange Detection Kit Standard, 10 Vials
Echelon Biosciences Research Labs LINOLENOYL LPA 10 mg
Linolenoyl LPA, 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Enzo Life Sciences BAY 61-3606. hydrochloride (1mg). CAS: 648903-57-5
Cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50=10nM). Highly selective if compared to other kinases; shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM. Anti-inflammatory and orally active. Exhibits good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. Alternative name: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl. Purity: ≥98% (HPLC(UV)). Appearance: Yellow solid. Solubility: Soluble in water (30mg/ml), DMSO (2mg/ml) or methanol (1mg/ml). Long Term Storage: -20°C.
Echelon Biosciences Research Labs PI(3,4)P2 PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Meso Scale Discovery Phos Tyr694TTL STAT5ab WCL 5
The Meso Scale Discovery Phospho-Tyr694/Total STAT5A/B Whole Cell Lysate Kit (K15163D) is a kit for detecting phosphorylated STAT5A/B and total STAT5A/B in cell lysates The kit contains a 96-well plate coated with capture antibodies against STAT5A/B and phospho-STAT5A/B Tyr694 It also includes detection antibodies and buffers needed to perform the assay The electrochemiluminescent detection allows for high sensitivity and a broad dynamic range This kit can be used to monitor STAT5A/B phosphorylation and activation in response to cytokines growth factors and drugs that modulate the JAK/STAT pathway It requires a low amount of sample and provides high-quality data
Meso Scale Discovery Phospho-STAT3 (Tyr705) Kit, 96-well plate, 25 plates, detects STAT3 pTyr705, suitable for human, mouse, rat samples, compatible with various MSD instruments
The MESO SCALE DISCOVERY Phospho-STAT3 (Tyr705) Kit is designed as a rapid and convenient assay for the detection of STAT3 phosphorylated at tyrosine 705. The kit is suitable for research applications focused on phosphoproteins and intracellular signaling across various species, including human, mouse, and rat. Utilizing a 96-well plate format, it enables efficient processing of samples with high-throughput compatibility.
- Detects STAT3 phosphorylated at Tyr705, a crucial activation site.
- Validated for use with human, mouse, and rat samples.
- Compatible with multiple MSD instruments.
- Contains all essential reagents for accurate results.
- Includes comprehensive kit contents such as SULFO-TAG antibody and various buffers.
- Intended for research use only.
- Stored as multi-component modules.
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 1 MG
Reticuline exhibits anti-inflammatory effects by influencing JAK2/STAT3 and NF-κB signaling pathways. It inhibits the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline also demonstrates cardiovascular effects.
- Inhibits JAK2/STAT3 and NF-κB signaling pathways.
- Reduces TNF-α and IL-6 mRNA expression.
- Decreases JAK2 and STAT3 phosphorylation.
- Shows cardiovascular effects.
- Purity of 98.89%.
- Appearance: white to yellow solid.
- Soluble in DMSO.