Signal Transduction Reagents and Kits
Enzo Life Sciences SB203580, (1mg), CAS Number: 152121-47-6
Protein kinase inhibitor. Cell permeable, specific inhibitor of p38 (SAPK2a). Inhibits p38 MAPK stimulation of MAPKAPK2 (IC.The concentrations of SB203580 required to block Akt phosphorylation (IC50= 3-5µM) are only approximately 10-fold higher than those required to inhibit p38 MAP kinase (IC50=0.3-0.5µM). These data define a new activity for this drug and suggest that extreme caution should be used when interpreting data when SB203580 has been used at concentrations above 1-2µM. Non-specific effects include inhibition of COX-1 and -2. Enhances clonal growth of skin epithelial progenitor cells and stimulates neural stem cell proliferation. Alternative Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole. Formula: C21H16N3FOS. MW: 377.4. CAS Number: 152121-47-6. Purity: ≥97% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO (50mg/ml). Long Term Storage: -20°C
Medchemexpress LLC Uk122 | 940290-58-4 | 99.9% | 291.30 g/mol | C17H13N3O2 | 5 MG
A selective small-molecule inhibitor of urokinase-type plasminogen activator (uPA) for biochemical and cellular research into protease-mediated processes such as cancer cell migration and invasion. It is a 4-oxazolidinone analogue with reported uPA inhibition (IC50 0.2 μM). Supplied as a research reagent, not for human or veterinary use.
- Selective uPA inhibition with IC50 of 0.2 μM.
- 4-oxazolidinone analogue suitable for mechanistic studies.
- High purity (~99.9%) for reproducible biochemical assays.
- Small-molecule format compatible with cell-based and enzymatic assays.
- Available in small research quantities for laboratory use.
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan United States Pharmacopeia (USP) Reference Standard | 139264-17-8 | MFCD00871503 | 200MG
Zolmitriptan United States Pharmacopeia (USP) Reference Standard | Mol Wt: 287.36 | 139264-17-8 | MFCD00871503 | 200MG
Creative Biomart Alglucosidase alfa, Recombinant Human enzyme acid alpha-glucosidase (GAA)
The product consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. The product is produced by recombinant DNA technology in a Chinese hamster ovary cell line. The product degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages of lysosomal glycogen. Structurally, the product is a glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates.
Echelon Biosciences Research Labs LINOLENOYL LPA 10 mg
Linolenoyl LPA, 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Selleck Chemical LLC SB202190 (FHPI) 25mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Akoya Biosciences INDIVIDUAL CYANINE 3 TYRAMIDE
TSA™ Cyanine 3 Tyramide Reagent Pack, Reagents for 50-150 Slides;
Enzo Life Sciences BAY 61-3606. hydrochloride (1mg). CAS: 648903-57-5
Cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50=10nM). Highly selective if compared to other kinases; shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM. Anti-inflammatory and orally active. Exhibits good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. Alternative name: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl. Purity: ≥98% (HPLC(UV)). Appearance: Yellow solid. Solubility: Soluble in water (30mg/ml), DMSO (2mg/ml) or methanol (1mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC Syk-IN-1 | 1491150-77-6 | 99.18% | 100 MG
Syk-IN-1 is a potent Syk inhibitor, with an IC50 of 35 nM. It is intended for research use only.
- Potent Syk inhibitor with an IC50 of 35 nM.
- Offered as a solid for various research applications.
- Optimal storage for powder: -20°C for 3 years or 4°C for 2 years.
- Optimal storage for solvent: -80°C for 6 months or -20°C for 1 month.
Enzo Life Sciences 8-Bromo-cGMP (50mg). CAS: 51116-01-9
A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets. Purity: ≥96% (HPLC). Solubility: Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol. Long Term Storage: -20°C.
![CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00111436-SUBS-016.PNG-250.jpg)
CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 1MG
SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidONE-LETTER SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-YVADAPV-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidMOLECULAR FORMULA: C61H76N12O14S1MOLECULAR WEIGHT: 1233.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [161877-70-9]SYNONYMS: Caspase 1 (ICE) Substrate; dabcyl-yvadapv-edans; dabcyl-tyr-val-ala-asp-ala-pro-val-edans; ICE Substrate Ii; il-1-beta Converting Enzyme Substrate Ii; il-1b Converting Enzyme Substrate Ii; 4-(4-dimethylaminophenylazo)benzoyl-tyr-val-ala-asp-ala-pro-val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid; 4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acidRESEARCH AREA: ApoptosisREFERENCES:M.W. Pennington et al., Peptide Res., 7, 72 (1994)M. Los et al., Nature 375, 81 (1995)SKU(s): SUBS-016A, SUBS-016B
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan Related Compound H United States Pharmacopeia (USP) Reference Standard | 1116-77-4 | MFCD00671479 | 50MG
Zolmitriptan Related Compound H United States Pharmacopeia (USP) Reference Standard | Mol Wt: 189.3 | 1116-77-4 | MFCD00671479 | 50MG