Signal Transduction Reagents and Kits
Enzo Life Sciences L-JNKi1 (1mg)
This L-stereoisomer is a cell permeable JNK (c-Jun N-terminal kinase) inhibitor. For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter. Neuroprotective agent for stroke. Inhibits the interaction between JNK (JNK-1, -2 and –3) and its substrate with the same IC50 (in vitro IC50 ~ 1µM), but is degraded more readily than the D-stereoisomer, thus requiring higher treatment concentrations in vitro and in vivo. Alternative name: JNK inhibitor 1 (L-stereoisomer), c Jun N terminal kinase peptide inhibitor 1, L stereoisomer. Purity: ≥95% (HPLC). Formulation: Lyophilized. Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences E-64-D, (1mg), CAS Number: 88321-09-9
Calpain and cathepsin inhibitor. Cell-permeable, ethyl ester of E-64-c. The ester is hydrolyzed by intracellular esterases to produce E-64-c. Inhibits calpain and cathepsins B, H, and L. Inhibits degradation of autophagic cargo inside autophagolysosomes. Alternative Name: 2S,3S-trans-(Ethoxycarbonyloxirane-2-carbonyl)-L-leucine-(3-methylbutyl) amide. Aloxistatin. Formula: C17H30N2O5. MW: 342.4. CAS Number: 88321-09-9. Purity: ≥98% (HPLC). Appearance: White solid. Solubility: Soluble in 100% ethanol (>10mg/ml) or DMSO (20mg/ml). Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months. Long Term Storage: -20°C
Sigma Aldrich Fine Chemicals Biosciences Mitoxantrone dihydrochloride 97 (HPLC), 70476-82-3, MFCD00242943
Mitoxantrone dihydrochloride 97 (HPLC)
Apexbio Technology LLC 3-Methyladenine, 5142-23-4, MFCD00010531, 50 mg
MF: C6H7N5, MW: 149.15, Solubility: 7.45mg/mL in DMSO, 5mg/mL in H2O. 3-Methyladenine is an inhibitor of class III phosphoinositide 3-kinase (PI3K).
Neogen Diagnostics K-Blue Luminescent ONE Substrate, 200 ML, HRP, Microwell, Chemiluminescent
K-Blue Luminescent ONE is a stabilized luminescent substrate for use with horseradish peroxidase immunoassays. It contains both luminol and hydrogen peroxide (H2O2) in a one-bottle format with long-term stability, high sensitivity, and excellent signal to noise. Maximal light emission occurs at 430 nm in the presence of peroxidase labeled conjugate. K-Blue Luminescent ONE is compliant with Annex XVII for REACH and contains no hazardous substances at or above published reporting levels. Stable for a minimum of 12-months when stored at 2-8C.
Enzo Life Sciences PROTEOSTAT Thioredoxin-1 assay kit (2x96wells)
Applications: Fluorescent detection. Contents: PROTEOSTAT PDI detection reagent: 20 μL. Thioredoxin-1 (human) (recombinant): 2 vials x 80 μL. Insulin: 2 vials x 1.8 μmol. Aurothiomalate (inhibitor): 2 vials x 25 nmol. PBE buffer: 25 mL. Stop reagent: 1 mL. DTT: 2 vials x 1.3 mL. Deionized water: 5 mL
Echelon Biosciences Research Labs EICOSANOYL LPA 1 mg
Arachidoyl LPA, 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA), a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Enzo Life Sciences SB-216763 (5mg). CAS: 280744-09-4
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences 1-Oleoyl-2-acetyl-sn-glycerol (10mg). CAS: 86390-77-4
In vitro potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets. Stimulates formation of actin nucleation sites. Stimulation of pp60c-src phosphorylation in EBV transformed B-cells, 470μM. Alternative name: OAG. Purity: ≥98% (TLC). Solubility: Soluble in DMSO or ethanol. Long Term Storage: -20°C.