Synonym: Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase. Type VIII, lyophilized powder, 300-1,000 U/mg. Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.