General Clinical Chemistry Analyzers and Accessories
Abcam LMK 235, HDAC inhibitor, 25MG
MW 294.35 Da, Purity >98%. Highly potent and selective HDAC inhibitor. Greater potency for HDAC4 and HDAC5 (IC₅₀ = 11.9 and 4.2 nM, respectively) than other HDAC family members (IC₅₀ values = HDAC1 320 nM, HDAC2 881 nM, HDAC6 55.7 nM, and HDAC8 1278 nM. Demonstrates inhibitor activity in human ovarian cell lines (IC₅₀ =0.49μM) and cisplatin resistant cell lines (IC₅₀ = 0.32μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 5MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CHIR-124, 5MG
MW 419.9 Da, Purity >98%. Novel and potent Chk1 inhibitor (IC₅₀ = 0.3 nM), 2,000-fold more potent than Chk2 (IC₅₀ = 0.7 μM). Also, potently targets other kinases such as FLT3 (IC₅₀ = 5.8 nM), PDGFR (IC₅₀ = 6.6 nM), GSK-3 (IC₅₀ = 23.3 nM) and Fyn (IC₅₀ = 98.8 nM) .
The product is subject to the following: Abcam Restricted Use Statement
Alkali Scientific 5mL False Bottom Analyzer Tubes with Threads, 16×97mm, Polypropylene (PP), Amber, 5000/Case
These 5mL False Bottom Analyzer Tubes (16×97mm) with Threads are designed for use in high volume chemistry and diagnostic analyzers. They are compatible with popular analyzers from Hitachi, Olympus, Corning, Ortho, Kodak, Beckman, IA, Tosoh, Vitros and more. Manufactured from high grade polypropylene (PP), these tubes offer excellent chemical resistance and can be safely autoclaved at 121 °C. With a conical false bottom for reduced dead volume and accurate sample retrieval, these tubes are ideal for serum collection, sample transport, or storage. Available in natural or amber options to protect light sensitive samples, they are self standing and designed to fit most universal analyzer racks, including AU 5000 systems. Features: 5mL nominal capacity, 16×97 mm Compatible with Hitachi, Olympus, Corning, Ortho, Beckman, Vitros, Tosoh, and other analyzers Made of chemical resistant polypropylene; autoclavable at 121 °C Available in natural or amber PP for light sensitific.
Abcam Elevenostat, 1MG
MW 315.32 g/mol, Purity >=95%. A small molecule hydroxamic acid derivative that acts as a HDAC11-selective inhibitor. Reporter assays using a luciferase-linked Foxp3 promoter shows that HDAC11 decreases the signal driven by NFκB/p65, alone or in the presence of transfected Foxp3, and impairs luciferase activity driven by p65, Foxp3 and the HAT enzyme, p300. The inhibitory effects of HDAC11 at the Foxp3 promoter are reversed by Elevenostat (JB3-22), (IC₅₀ 0.235 μM). Elevenostat also partially reverses the inhibitory effect of HDAC11 on p300-induced Foxp3 acetylation at lysine 31 consistent with the ability of HDAC11 to directly regulate acetylation of Foxp3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Acetazolamide, carbonic anhydrase inhibitor, 5MG
MW 222.3 Da, Purity >98%. Non-specific carbonic anhydrase inhibitor with diverse physiological effects that are cell and tissue specific. Heterocyclic primary sulfonamide.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Merafloxacin
Chemical. CAS 91188-00-0. Formula C19H23F2N3O3. MW 379.4. Merafloxacin is a fluoroquinolone broad-spectrum antibacterial compound. It is an inhibitor of bacterial DNA gyrase and Type II DNA topoisomerase. It demonstrated excellent activity against Gram-positive organisms and less potent activity against Gram-negative bacteria. Merafloxacin is a programmed -1 ribosomal frameshifting -1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other betacoronaviruses and blocks SARS-CoV-2 replication in Vero E6 cells. The compound reduced viral levels in infected African green monkey VeroE6 cells in a concentration-dependent manner. Merafloxacin showed no cellular toxicity and resulted in a 3 to 4 orders of magnitude reduction of SARS-CoV-2 titer, with IC50 of 4.3 µMu.
Perkin Elmer US LLC Copper Diffusion Plug
The best way to assure consistent, accurate results from your Organic Elemental Analyzer is to use only the highestgrade of reagents. Our scientists select the purest raw materials, condition them,then test them on PerkinElmer analyzers.
Abcam Calcein Blue AM acetate, 1MG
MW 465.4 Da, Purity >95%. Blue fluorescent cell viability probe which won't overlap with green fluorescence from other probes. Penetrates live cell membranes and is virtually non-fluorescent. Upon ubiquitous esterase enzyme activity it produces a bright blue fluorescent that is trapped in live cells - convenient for measurement by epifluorescence light microscopy or flow cytometry. Useful to measure the total number of live versus dead cells - dye leaks out quickly due to the compromised membrane in dead cells resulting in no staining.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GSK2656157, 5MG
MW 416.5 Da, Purity >=98%. Potent and selective PERK inhibitor (IC₅₀ = 0.9 nM in cell-free assay). ATP-competitive. Exibits 500-fold selectivity for PERK versus a panel of 300 kinases.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CCT128930, 50MG
MW 341.8 Da, Purity =98%. Potent and selective AKT2 inhibitor (IC50= 6 nM) with selectivity greater than 28-fold and 20-fold over PKA kinase (IC50= 168 nM) and p70S6K (IC50= 120 nM), respectively.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Apremilast, 5MG
MW 460.5 Da, Purity >98%. Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GLPG-1690, 25MG
MW 588.7 Da, Purity >=98%. Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dinaciclib, cyclin-dependent kinase (CDK) inhibitor, 5MG
MW 396.5 Da, Purity >98%. Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC₅₀ values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC₅₀ = 4 nM).
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Rilpivirine
Chemical. CAS 500287-72-9. Formula C22H18N6. MW 366.4. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor NNRTI that inhibits growth of wild-type HIV with an EC50 value of 0.51nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1nM for L100I, K103N, V106A, G190A and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates EC50s = <10nM, including strains containing up to eight resistance mutations. NNRTIs work by binding to and blocking HIV reverse transcriptase, which prevents HIV from replicating and lowers the amount of HIV in the blood. Rilpivirine is an antiviral anti-HIV drug, active against wild-type and NNRTI-resistant HIV-1 with higher potency, longer half-life and reduced side-effect profile compared with Efavirenz Prod. No. AG-CR1-3751. CARD8 inflammasome senses HIV-1 protease activity.