Systematic combinations of a large variety of peptides manufactured to customer specifications; can be used for target screening in research areas such as immunotherapy, vaccine development, drug discovery, and proteomics.
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Recombinant HEK293T cells stably overexpress coronavirus SARS-CoV-2 spike protein on the surface The surface expression of SARS-CoV-2 spike protein is validated by FACS analysis This stable cell line product is designed for screening antibodies against SARS-CoV-2 spike protein as well as for measuring binding affinity and stability of antibody based biologics that bind with spike protein GenScript also offers spike protein expressing CHO-K1 stable cell line (Cat No M00803) for SARS-CoV-2 study
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A multi-kinase inhibitor (IC50s 4.5 and 66 nM for human recombinant RET and KDR respectively) inhibits EGFR (IC50 4 M) binds to TTBK1 (Kds 0.46 and 0.24 M for phosphorylated and non-phosphorylated TTBK1 respectively) inhibits JAK3-driven graft versus host disease responses in mice receiving allogenic bone marrow and splenocyte grafts inhibits IgE-induced vascular hyperpermeability in a mouse model of passive anaphylaxis
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An anticoagulant reversal agent selectively binds to unfractionated heparin enoxaparin and Factor IXa (Kds 28 17 and 35 UM respectively) over edoxaban rivaroxaban Factor Xa Factor IX thrombin antithrombin and fibrinogen and only weakly binds to an enoxaparin-antithrombin complex and fondaparinux (Kds 690 and 9600 UM respectively) in cell-free assays prevents edoxaban-induced decreases in fibrin diameter in isolated human whole blood at 200 Ug/ml reduces edoxaban- dabigatran- apixaban- rivaroxaban- unfractionated heparin- or enoxaparin-stimulated increases in tail transection-induced blood loss in rats
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An antimalarial agent (MICs 10-500 nM for P. falciparum) inhibits hemozoin formation in purified trophozoites leading to an increase in free heme reduces mouse P. berghei parasite load in the blood with an MED of 150 mg/kg
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An inhibitor of COX-1 (IC50 0 8 M) selective for COX-1 over COX-2 (IC50 210 M) reduces acetic acid-induced writhing in mice at 10 and 30 mg/kg has analgesic activity in the formalin test in rats at 30 mg/kg does not induce gastric damage in rats at doses up to 300 mg/kg
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SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases As of May 2021 three sublineages have been found Despite its name B 1 617 3 was the first sublineage of this variant to be detected in October 2020 in India This sublineage has remained relatively uncommon compared to the two other sublineages B 1 617 1 (also known as variant Kappa) and B 1 617 2 (also known as variant Delta) both of which were first detected in December 2020 This variant has the double mutations E484Q and L452R in the spike proteins Emerging research suggests the variant may be more transmissible than previously evolved ones Whether the effectiveness of currently-deployed vaccines is affected remains under investigation Moreover the sublineage B 1 617 2 has been redesignated as variant of concern (VOC-21APR-02) in May 2021 which spreads more quickly than the origin
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