Custom Peptides
Cayman Chemical SB-269970hydrochlorIde 10mg
A potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors
Cayman Chemical LpBromotetramIsoleoxalate 10mg
A cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 µM for PLAP and NSAP, respectively); also used as a tyrosine phosphatase inhibitor
Cayman Chemical BromfenacsodIum salt 10mg
A COX-2 inhibitor (IC50 = 6.6 nM); selective over COX-1 (IC50 = 210 nM); inhibits PGE2 production in a rabbit model of LPS-induced eye inflammation; decreases inflammation following cataract removal in dogs (0.9% topically on a tapering schedule for 24 weeks)
Cayman Chemical ZatebradInhydrochlorIde 10mg
Blocks If currents through HCN channels in sinoatrial node cells (IC50s = 1.83, 2.21, 1.9, and 1.88 µM, respectively for HCN1-4 in vitro); reduces heart rate from 600 to 200 beats per minute with an ED50 value of 1.8 mg/kg and induces increasing arrhythmia at concentrations >10 mg/kg when assessed through telemetric ECG recording in mice
Cayman Chemical DynorphIn AtrIfluoROCTAte 10mg
A heptadecapeptide that acts as an endogenous opioid receptor agonist (Kis = 0.5-1 nM for κ, µ, and δ); has been implicated in antinociceptive functions
Cayman Chemical Ppequaln 10mg
A partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay); potentiates muscle relaxant and hypnotic effects of diazepam in mice; increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity
Cayman Chemical PyrrolIdIn LInoleamIde 10mg
A derivative of the amide of linoleic acid that shows potent antiproliferative activity against an array of cancer of cell lines
Cayman Chemical GambogIc AcId 10mg
A xanthonoid with anticancer activity; binds covalently to SPTSSB (Ki = 1.5 µM; kinact = 0.05 min-1) and inhibits de novo sphingolipid biosynthesis; activates caspases in T47D breast cancer cells (EC50 = 0.78 µM); inhibits binding of anti-apoptotic proteins to a BH3 peptide (IC50s = 1.47, 1.21, 2.02, 0.66, 1.06, and 0.79 μM for Bcl-xL, Bcl-2, Bcl-W, Bcl-B, Bfl-1, Mcl-1, respectively); binds to the transferrin receptor (IC50 = 4.1 µM); reduces growth of a variety of cancer cell lines (GI50s = 0.115-1 µM) and induces apoptosis in T47D cells; a slow inhibitor of inward-rectifying potassium channel 2.1 (Kir2.1; IC50 = <0.1 µM)
Cayman Chemical RosuvastatIncalcIum salt 10mg
An HMG-CoA reductase inhibitor (IC50 = 5 nM); inhibits cholesterol synthesis in isolated rat hepatocytes (IC50 = 0.16 nM); reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet at 10 mg/kg; decreases the area of aortic atherosclerotic lesions in the same model
Cayman Chemical ElIptIcInhydrochlorIde 10mg
A DNA-intercalating antitumor agent that forms covalent adducts in DNA after being enzymatically activated with CYP3A4, CYP1A1, or CYP1A2 or by peroxidases in target tissues; inhibits the proliferation of human breast adenocarcinoma, leukemia, neuroblastoma, and glioblastoma cells (IC50s = 0.27-4.7 µM)
Cayman Chemical 2Phenyl2 1pIperIdInylpro 10mg
A mechanism-based inactivator of human CYP2B6 (Ki = 5.6 µM; IC50 = 5.1 µM) with potent selectivity for CYP2B6 over other CYP450 isoforms
Cayman Chemical Galoflavn 10mg
An LDH inhibitor (Kis = 5.46 and 15.06 µM, for the A and B isoforms, respectively) that prevents proliferation of many different cancer cells by blocking glycolysis and ATP production
Cayman Chemical 5fluoro PB22 8hdroxIsoqu 10mg
Differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its eight position; intended for forensic and research purposes
Cayman Chemical 5 NethylNIsopropylAmIlo 10mg
A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively; less effectively inhibits NHE4 (IC50 ≥10 μM)
Cayman Chemical PROSGlnDN F2a 1 15lacton 10mg
PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates EArly pregnancy, whereas PGF2α is ineffective.{4371}