Custom Peptides
Cayman Chemical ReldesemtIv 10mg
An activator of fast skeletal troponin; increases ATPase activity in isolated rabbit psoas muscle myofibril preparations (AC40 = 0.6 µM); selective for fast skeletal troponin over cardiac and slow skeletal troponin; selective for fast skeletal troponin over a panel of 79 enzymes, receptors, ion channels, and transporters at 100 µM; increases muscle tension in a skinned fast skeletal muscle fiber assay (DF30 = 0.8 µM); increases running time in the rotarod test, indicating increased exercise performance, in a rat model of heart failure-induced skeletal myopathy at 10 mg/kg, p.o.
Cayman Chemical NundecnoylLHomoserIn lac 10mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM; inhibits concanavalin A-induced proliferation of isolated mouse splenocytes (IC50 = 90 µM)
Cayman Chemical 15hydroxy PentadecNIc ACD 10mg
A hydroxy fatty acid methyl ester; a key intermediate in the synthesis of the musk-odored macrocyclic lactones cyclopentadecanolide and exaltolide
Cayman Chemical AcalabrutInIb 10mg
An irreversible BTK inhibitor; dose-dependently inhibits B cell receptor signaling in primary CLL cells
Cayman Chemical Enarodustat 10MG
A pan HIF-PH inhibitor (Kis = 16, 61, and 101 nM for HIF-PH1, -2, and -3, respectively); increases EPO levels in Hep3B cells (EC50 = 4.7 µM); increases plasma EPO levels in control rats, as well as plasma EPO and hemoglobin levels in 5/6-nephrectomized rats at 3 mg/kg; decreases renal fatty acid and amino acid metabolism and increases renal glucose metabolism in streptozotocin-induced rat and alloxan-induced mouse models of diabetic nephropathy
Cayman Chemical CephalosporIn CzInc 10mg
A cephalosporin antibiotic; active against a variety of bacteria, including S. pyogenes, C. diphtheriae, E. coli, and H. influenzae (MICs = 31, 15.6, 125, and 31 UG/ml, respectively), as well as clinical isolates of N. gonorrhoeae (MICs = 1.9-15.6 UG/ml)
Cayman Chemical N-Benzyl LInoleamIde 10mg
A soluble epoxide hydrolase inhibitor (IC50s = 0.155, 0.041, and 0.044 µM for the human, rat, and mouse enzymes, respectively); selective for sEH over FAAH (IC50 = 10.8 µM for the human enzyme); inhibits production of NF-κB (IC50 = 8.80 µM) and activates Nrf2 (EC50 = 35.24 µM) in Neuro2a cells; increases the paw withdrawal threshold in a mouse model of LPS-induced inflammatory pain at 100 mg/kg
Cayman Chemical nsIrItIdeacetate 10mg
A natriuretic peptide; increases ex vivo A23187-induced vasorelaxation in porcine hearts isolated from a model of acute coronary occlusion at 2 UG/kg bolus dose followed by 0.01 UG/kg per minute infusion
Cayman Chemical LY344864hydrochlorIde 10mg
A 5-HT1F receptor agonist (Ki = 6 nM); selective for 5-HT1F over 5-HT1A-E , 5-HT2A-C, and 5-HT7 receptors (Kis = 0.53-4.85 µM), as well as dopamine D1 and D2, GABAA, histamine H1, muscarinic, and α1-, α2-, and β-adrenergic receptors (Kis = 3.69->100 µM); inhibits forskolin-stimulated cAMP accumulation in L-M(TK-) cells expressing recombinant human 5-HT1F receptors (EC50 = 3 nM); decreases electrically stimulated extravasation of plasma proteins in the dura mater in a rat trigeminal nerve model of migraine headache (ID50s = 0.6 and 2.1 ng/kg for i.v. and oral administration, respectively)
Cayman Chemical SC144hydrochlorIde 10mg
A gp130 inhibitor; inhibits phosphorylation of STAT1, STAT3, and Akt induced by LIF and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells at 20 µM; induces cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines (IC50s = 0.4-4 µM); reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models
Cayman Chemical NNItrosoNmethyl4AmInobut 10mg
A nitrosamine carcinogen; oxidized to MOPN in isolated rat liver mitochondria; induces bladder transitional cell carcinomas in rats at 300 mg/L per day in the drinking water
Cayman Chemical Toosendanin 10mg
A triterpenoid with diverse biological activities; inhibits proliferation of BEL-7404, U251, SH-SY5Y, HL-60, PC3, and U937 cancer cells (IC50s = A. aegypti first instar larvae (LC50 = 60.8 UG/ml) and delays pupal development at 6.3-25 UG/ml; decreases serum levels of TNF-α, IL-1β, and IL-6 in a mouse model of ulcerative colitis induced by DSS at 0.5 and 1 mg/kg; increases survival in a mouse model of BoNT/A-induced botulism at 9 mg/kg
Cayman Chemical TetrabenazIn 10mg
An inhibitor of VMAT2 that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay); dose-dependently reduces levels of the monoamines norepinephrine, dopamine, and 5-HT in rat brain; has been used to induce depressive-like behavior in animal models; improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal MSNs in a YAC128 transgenic mouse model of Huntington’s disease at 5 mg/kg
Cayman Chemical RaxatrIgInhydrochlorIde 10mg
An inhibitor of voltage-gated sodium channels (IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1- Nav1.8 channels); has state-dependent activity at the Nav1.7 channel (IC50s = 6.3 and 54 µM for open/inactivated and closed/resting states); decreases pain behavior in an OD1 mouse pain model