Custom Peptides
Cayman Chemical LotIglIpronhydrochlorIde 10mg
A GLP-1R agonist; induces cAMP accumulation in cells expressing human GLP-1R (EC50 = 0.96 nM)
Cayman Chemical OmIdenpagfree acId 10mg
A non-prostaglandin EP2 receptor agonist; selectively binds to human EP2 over EP1, EP3, and EP4 receptors (IC50s = 10, >10,000, >10,000, and 5,480 nM, respectively); induces cAMP accumulation in HEK293 cells expressing human EP2 receptors (EC50 = 1.1 nM)
Cayman Chemical TetrahydroharmIn 10mg
A fluorescent indole alkaloid extracted from B. caapi that inhibits MAO-A and MAO-B with much weaker potency (IC50s = 74 nM and >100 μM, respectively) compared to its companion harmala alkaloids: harmaline (IC50s = 2.5 nM and 25 μM, respectively) and harmine (IC50s = 2 nM and 20 μM, respectively)
Cayman Chemical ReparIxInL-LysIn salt 10mg
A non-competitive allosteric inhibitor of IL-8/CXCL8 activation of CXCR1 and CXCR2 chemokine receptors (IC50s = 1 and 100 nM, respectively); blocks IL-8-induced leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists; at 100 nM, depletes a cancer stem cell population in human breast cancer cell lines in vitro
Cayman Chemical ChlorothIazIde 10mg
An analytical reference standard categorized as a thiazide diuretic; intended for analytical forensic applications
Cayman Chemical KaempfRol 3nohSpRIdosID 10mg
A flavonoid with antioxidant and antidiabetic activities; scavenges DPPH radicals (IC50 = 79.6 UG/ml); increases glucose uptake in isolated rat soleus muscle at 1 and 100 nM; increases glycogen synthesis in isolated rat soleus muscle at 1 µM; reduces serum glucose levels in a rat model of alloxan-induced diabetes at 100 mg/kg
Cayman Chemical DocosahexaenoylLcarnItIn 10mg
A long-chain acylcarnitine; decreased venous cord plasma levels are associated with babies born small for gestational age
Cayman Chemical TrIbulosIdehydrate 10mg
A flavonoid; active against M. madagascariense and M. indicus pranii (MICs = 0.8 and 1.6 mg/ml); scavenges DPPH radicals at 63.7-75.2 mg/ml
Cayman Chemical 3-FormylsalIcylIc AcId 10mg
An inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM); has been used in the synthesis of Schiff bases
Cayman Chemical DesglymIdodrIn 10mg
An active metabolite of midodrine; an agonist of α1-ARs; binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively); increases IUP and MAP in anesthetized dogs by 5 and 20 mm Hg, respectively, in anesthetized dogs at 205 and 250 nmol/kg, respectively
Cayman Chemical CGP 55845hydrochlorIde 10mg
A GABAB receptor antagonist (Ki = 4.5 nM); increases electrical stimulation-induced GABA release in the absence and presence of (–)-baclofen, as well as glutamate release in the presence of (–)-baclofen, in rat cerebral cortex slices (EC50s = 8.3, 25, and 14 nM, respectively); inhibits (–)-baclofen-induced postsynaptic hyperpolarization of evoked IPSPs and fEPSPs in rat CA1 hippocampal slices at 1 µM; increases swimming time, but does not decrease immobility time, in the forced swim test in rats at 3 or 10 mg/kg; reverses age-induced impairments in olfactory discrimination learning in rats at 0.01 and 0.1 mg/kg; increases seizure intensity in a mouse model of PTZ kindling-induced epilepsy
Cayman Chemical -N-desmethyl VenlafaxIn 10mg
A minor active metabolite of venlafaxine; formed from venlafaxine by CYP3A4; inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively); reverses reserpine-induced hypothermia in mice (MED = 10 mg/kg)