RNAi Services and Custom Production
ABclonal Technology Niemann-Pick type C2NPC2
This gene encodes a protein containing a lipid recognition domain The encoded protein may function in regulating the transport of cholesterol through the late endosomal lysosomal system Mutations in this gene have been associated with Niemann-Pick disease type C2 and frontal lobe atrophy
ABclonal Technology Niemann-Pick type C2NPC2
This gene encodes a protein containing a lipid recognition domain The encoded protein may function in regulating the transport of cholesterol through the late endosomal lysosomal system Mutations in this gene have been associated with Niemann-Pick disease type C2 and frontal lobe atrophy
Vector Laboratories Peanut Agglutinin, CY3, 1 mg FL-1181-2
Peanut Agglutinin (PNA), CY3, 1 mg, binds preferentially to the T-antigen, a galactosyl (beta-1,3) N-acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. With certain exceptions, the receptor sequence for PNA is normally sialylated, which prevents the lectin from binding to its receptor oligosaccharide (see Jacalin). Even sialic acid which is not bound directly to the receptor sugars may inhibit binding. The presence of calcium ions in diluents can enhance the binding of PNA to receptors, possibly by neutralizing the negative charges on sialic acid residues adjacent to the receptor sequence. Cy3-labeled Peanut agglutinin has an appropriate number of fluorochromes bound to provide the optimum staining characteristics for this lectin. This conjugate is supplied essentially free of unconjugated fluorochromes. Excitation: 550 nm; Emission: 570 nm; Color: Red.
