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3 3 -cGAMP (3 3 -cyclic GMP-AMP Cyclic GMP-AMP cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING) thereby inducing an antiviral state and the secretion of type I IFNs
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Nucleotides are organic molecules that serve as the monomers or subunits of nucleic acids (like DNA and RNA). The building blocks of nucleic acids nucleotides consist of a nitrogenous base (purine or pyrimidine) a five-carbon sugar (ribose or deoxyribose) and at least one phosphate group. A nucleoside along with a phosphate group yields a nucleotide.
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Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. The protein also contains mutation of interested Q61K loaded with GppNHp, a non-hydrolysable GTP analog. Ready for use in Kras-RAF binding assay or inhibitor screening assay.
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An ionizable cationic lipid LNPs containing IZ-chol can be complexed with DNA with the plasmid-binding efficacy dependent in part on the type of helper lipids in the LNP formulation
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