A KAT6A and KAT7 inhibitor (IC50s 17 and 30 nM respectively) selective for KAT6A and KAT7 over KAT5 (IC50 312 nM) reduces the viability of primary mouse LSCs MOLM-13 and OCI-AML-3 AML cells as well as decreases colony formation in patient-derived primary AML cells at 1 UM induces cell cycle arrest at the sub-G1 phase and apoptosis as well as decreases the levels of mRNA encoding HOXA7 in MOLM-13 cells at 1 UM reduces tumor volume weight and growth rate as well as decreases the acetylation at H3K14 H3K12 and H3K5 in tumor cell lysates in a PPC-1 prostate cancer mouse xenograft model
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the histamine H1 receptor in serum-starved HeLa cells at 10 20 or 30 UM inhibits PMA-induced increases in the levels of mRNA encoding Il-4 in RBL-2H3 cells at 50 or 150 UM decreases LPS-induced increases in NO production in RAW 264.7 macrophages (IC50 27 UM) increases survival in a mouse model of CLP-induced sepsis at 2.5 or 5 mg/kg reduces the number of sneezes and the extent of nasal redness swelling and watery rhinorrhea in a rat model of TDI-induced allergies at 20 mg/kg per day
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Medchemexpress, HY-10443 5mg Balapiravir CAS:690270-29-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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A form of thymidine in which the hydroxyl group on carbon 5 of ribose has been replaced with hydrogen and cannot be phosphorylated competitively inhibits the cellular influx of thymidine
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