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5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity. REPROGRAMMING· Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.).· Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.). DIFFERENTIATION· Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.).CANCER RESEARCH· Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia
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The C-5 glycoside isomer of uridine; formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme; found in tRNAs from bacteria, archaea, and eukaryotes; reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner
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Medchemexpress, HY-17423 10mg Abacavir CAS:136470-78-5 Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress, HY-17423A 10mg Abacavir (sulfate) CAS:188062-50-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Nucleoside-Analog-2 is a 4'-azidocytidine analogue that inhibits Hepatitis C virus replication and is supplied as a click-chemistry reagent. It contains an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) with suitable partners.
4'-azidocytidine analogue active against HCV replication.
Contains an azide group for CuAAC and SPAAC click chemistry.
Purity ≥95.0% and molecular weight 285.21 g/mol.
Available as solid in multiple mg sizes and as 10 mM solution in DMSO.
Powder storage: -20°C for 3 years or 4°C for 2 years; solution storage: -80°C for 2 years.
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