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5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity. REPROGRAMMING· Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.).· Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.). DIFFERENTIATION· Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.).CANCER RESEARCH· Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia
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2'-O-Methylcytidine is an orally active 2'-substituted nucleoside that acts as an inhibitor of HCV replication with antiviral activity. It inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, competitively with substrate nucleoside triphosphate. The product is for research use only and not sold to patients.
Orally active 2'-substituted nucleoside.
HCV replication inhibitor.
Possesses antiviral activity.
Inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro.
Competitive inhibitor with substrate nucleoside triphosphate.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More