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2′-O-Methyluridine is a modified nucleoside found in T. thermophile tRNA. Its serum level is decreased in breast cancer patients. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which reduces ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs.
Modified nucleoside
Found in T. thermophile tRNA
Decreased in serum levels in breast cancer patients
Used in siRNA targeting apolipoprotein B
Reduces ApoB protein levels
Prevents IFN-α production
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Medchemexpress, HY-77651 5mg Nucleoside-Analog-1 CAS:876707-99-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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N4-methylcytidine is a cytidine nucleoside analog used as a research reagent to study nucleoside metabolism and DNA methylation-related processes. It is supplied as a high-purity solid with documented storage and solubility properties for use in biochemical and cellular assays.
Cytidine nucleoside analog for research use.
High purity (99.99%).
White to off-white solid appearance.
Storage: solid at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
Soluble in DMSO at 50 mg/mL; ultrasonic assistance may be required.
Available in multiple package sizes, including 250 mg.
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An alkylating agent with anticancer activity (IC50 = 1.5 μM against P388 murine leukemia cells); alkylates DNA and inhibits thymidine incorporation (IC50 = 2 μM) inducing irreversible DNA damage; crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand cross-links in L1210 and MCF-7 cancer cells in vitro; reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells; decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice
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2'-O-Methyluridine-d3 is deuterium labeled 2'-O-Methyluridine (HY-W011824). 2'-O-Methyluridine is a modified nucleoside found in *T. thermophile* tRNA. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which decreases ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs. The level of 2'-O-Methyluridine in serum is decreased in patients with breast cancer. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Can be used as a tracer
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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