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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
MW 354.1 Da, Purity >98%. Selective cytotoxic cell-permeable anti-herpesvirus agent (IC₅₀ = 4.3 μM). Radiosensitizing. Incorporates into DNA increases susceptibility of cancer cell to radiation damage. Active in vivo. .
Nucleotides are organic molecules that serve as the monomers or subunits of nucleic acids (like DNA and RNA). The building blocks of nucleic acids nucleotides consist of a nitrogenous base (purine or pyrimidine) a five-carbon sugar (ribose or deoxyribose) and at least one phosphate group. A nucleoside along with a phosphate group yields a nucleotide.
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N1-Methylpseudo-UTP (sodium salt) is a modified nucleotide analog utilized as a substrate for enzymatic in vitro transcription reactions aimed at generating messenger RNA (mRNA) molecules for biomedical research This nucleotide contains the N1-methylpseudouridine base modification which helps to reduce innate immune system activation triggered by exogenous mRNA transcripts within mammalian cells Incorporating N1-methylpseudo-UTP into synthetic transcripts decreases recognition by intracellular pattern-recognition receptors thereby lowering innate immune responses and enhancing cellular tolerance upon transfection Consequently N1-methylpseudo-UTP incorporation has been actively employed in developing mRNA constructs for therapeutic applications such as vaccine development protein replacement therapies and gene-editing platforms
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MW 242.23 Da, Purity >98%. Pyrimidine deoxynucleoside. Potent thymidine kinase substrate (IC₅₀ = 16 nM). Pairs with deoxyadenosine in double-stranded DNA. Synchronizes cells in S phase in vivo. .
MW 242.23 Da, Purity >98%. Pyrimidine deoxynucleoside. Potent thymidine kinase substrate (IC₅₀ = 16 nM). Pairs with deoxyadenosine in double-stranded DNA. Synchronizes cells in S phase in vivo. .
MW 242.23 Da, Purity >98%. Pyrimidine deoxynucleoside. Potent thymidine kinase substrate (IC₅₀ = 16 nM). Pairs with deoxyadenosine in double-stranded DNA. Synchronizes cells in S phase in vivo. .