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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
7-Deaza-7-Propargylamino-dATP is a chemically modified nucleotide analog derived from deoxyadenosine triphosphate It is designed to enable enzymatic incorporation by DNA polymerases during DNA synthesis thereby facilitating site-specific labeling of DNA 7-Deaza-7-Propargylamino-dATP exerts its biological activity primarily through incorporation into nascent DNA strands introducing a terminal propargyl group that serves as a reactive alkyne handle for conjugation reactions via click chemistry approaches Based on these pharmacological properties 7-Deaza-7-Propargylamino-dATP holds research potential in DNA labeling fluorescent probe generation and studies of DNA polymerase activity specificity and DNA damage detection and repair mechanisms in molecular biology and biomedical research
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