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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
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Adenosine 5′-monophosphoramidate sodium is an adenosine derivative used as an intermediate for nucleotide synthesis. It significantly affects the accumulation of cyclic AMP.
An adenosine derivative
Can be used as an intermediate for nucleotide synthesis
Significantly affects the accumulation of cyclic AMP
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2-Thio-UTP is a base-modified ribonucleoside triphosphate commonly used in RNA-based biomedical research Incorporation of 2-Thio-UTP into RNA transcripts reduces innate immune activation compared to unmodified RNA Mechanistically RNAs transcribed with 2-Thio-UTP lack the ability to activate RNA-dependent protein kinase (PKR) markedly diminish 2 -5 -oligoadenylate synthetase (OAS) pathway induction decrease recognition by retinoic acid-inducible gene I (RIG-I) and suppress Toll-like receptor (TLR) mediated signaling Thus 2-Thio-UTP serves as a research tool in studies designing low-immunogenic RNAs for therapeutic applications
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Cyanine 3-AA-CTP is a fluorescently labeled cytidine triphosphate derivative conjugated with the fluorophore Cy3 During in vitro transcription reactions Cyanine 3-AA-CTP is enzymatically incorporated into RNA strands producing Cy3-labeled RNA molecules suitable for fluorescence-based analyses Due to Cy3 s high fluorescence intensity and photostability the labeledRNAs facilitate diverse studies such as fluorescence microscopy imaging RNA-protein interaction assays and sensitive RNA detection methodologies Consequently Cyanine 3-AA-CTP serves as an important reagent for investigating RNA biology and function
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2’3’-cGAMP Control, also known as 2’5’-GpAp, is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases.
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5-FAM-Alkyne is a highly selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP). It is also a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups. The FAM fluorophore can easily diffuse into a solution, emitting a strong fluorescence signal.
Highly selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP)
Functions as a click chemistry reagent
Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules
Contains a FAM fluorophore for strong fluorescence signal emission
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