RNAi Controls
ABclonal Technology ROBO1 Rabbit pAb
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Genscript Corporation CD37 hFc Chimera Human
CD37 is a tetraspanin expressed prominently on the surface of B cells It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia Currently several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials Given the unique role of CD37 in the biology of B cells it seems that CD37 constitutes more than a docking point for monoclonal antibodies and targeting this molecule may provide additional benefit to relapsed or refractory patients
Genscript Corporation CD3ECD3G hFc Chimera Biotin
T-cell surface glycoprotein CD3 epsilon CD3 gamma chain also known as CD3E CD3G are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation SLAMF7/CRACC/CD319 mFc Chimera
CD2-like receptor activating cytotoxic cells (CRACC) also known as CS1 novel Ly9 SLAMF7 and CD319 is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response
Refrigiwear Inc. Iron Tuff Snap-on Hood
Complete your protection by adding the Iron-Tuff Snap-On Hood to your Iron-Tuff jacket. Headwear is vital to keeping warm. Extend your -50°F protection with the same Iron-Tuff warmth, toughness and durability you already know and trust.
Genscript Corporation PD-L1 Fc Chimera Mouse
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy tissue allografts autoimmune disease and other disease states such as hepatitis Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8 T cell The formation of PD-1 receptor / PD-L1 or B7 1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8 T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2 PD-L
Genscript Corporation IL-17R alpha/CD217 hFc Chimera
Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22
Genscript Corporation CD28H/IGPR-1 hFc Chimera Huma
CD28H is constitutively expressed on all naive T cells Repetitive antigenic exposure however induces a complete loss of CD28H on many T cells and CD28H negative T cells have a phenotype of terminal differentiation and senescence After extensive screening in a receptor array a B7-like molecule B7 homologue 5 (B7-H5) was identified as a specific ligand for CD28H
Genscript Corporation CD3ECD3D hFc Chimera Human
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD164 hFc Chimera Human
CD164 was found to play a role in many malignant diseases CD164 was associated with clinical and pathological features of patients High level of CD164 was related to the distant metastasis and vascular invasion of bladder cancer patients CD164 was associated with the poor clinical outcomes of BC patients Silencing of CD164 could inhibit the progression of tumors in vivo and in vitro which may become an effective target in the treatment of bladder cancer
Genscript Corporation CD30/TNFRSF8 hFc Chimera Huma
The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153 TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions CD30 expression is upregulated in various hematological malignancies including Reed-Sternberg cells in Hodgkin s disease (HD) anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin s lymphomas (NHLs)
Genscript Corporation CD3ECD3G hFc Chimera Human
T-cell surface glycoprotein CD3 epsilon CD3 gamma chain also known as CD3E CD3G are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
STA PHARMACEUTICAL US LLC DNA A(Bz) amidite | 10 g | CAS 98796-53-3 | MDL MFCD00036314
DNA A(Bz) amidite is a Amidite reagent (Subcategory: Adenine Series) sold by WuXi TIDES. Offered in 10 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 98796-53-3
- MDL: MFCD00036314
- InChIKey: GGDNKEQZFSTIMJ-AKWFTNRHSA-N
- Molecular Weight: 857.948761998
- Molecular Formula: C47H52N7O7P
- Purity: ≥99%
- Container Type: 250 mL Glass (28-400)
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 179.7 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1C[C@H](N2C3=C(N=C2)C(NC(C4=CC=CC=C4)=O)=NC=N3)O[C@@H]1COC(C5=CC=C(C=C5)OC)(C6=CC=C(C=C6)OC)C7=CC=CC=C7)OCCC#N)C(C)C)C
Genscript Corporation Her3/ErbB3 hFc Chimera Human
Her3 also called ErbB3 is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors Her3 is expressed in keratinocytes melanocytes skeletal muscle cells embryonic myoblasts and Schwann cells Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG)