Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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136
Tocris Bioscience™ AP C5
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective PKG2 inhibitor
| CAS | 2234272-10-5 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C16H13N5 |
| Formula Weight | 275.31 |
137
Tocris Bioscience™ ML 323
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Potent and selective USP1-UAF1 allosteric inhibitor
| CAS | 1572414-83-5 |
|---|---|
| Purity | 98% |
| Recommended Storage | Store at -20°C |
| Synonym | 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine |
| Molecular Formula | C23H24N6 |
| Formula Weight | 384.48 |
138
Tocris Bioscience™ NCL 00017509
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CAS: 1507367-00-1 Molecular Formula: C15H12N6O
| CAS | 1507367-00-1 |
|---|---|
| Molecular Formula | C15H12N6O |
139
| CAS | 71320-77-9 |
|---|---|
| Molecular Formula | C13H17ClN2O2 |
140
Tocris Bioscience™ GSK 2193874
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Potent and selective TRPV4 antagonist; orally active
| CAS | 1336960-13-4 |
|---|---|
| Chemical Name or Material | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C37H38BrF3N4O |
| Formula Weight | Observed MW: 691.62 |
| Assay Percent Range | >98% |
141
Tocris Bioscience™ GNF 7
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Ras signaling inhibitor; inhibits Ack1 and GCK
| Target | Small G Protein Inhibitors |
|---|---|
| CAS | 839706-07-9 |
| Purity | >98% |
| Chemical Name or Material | Ras GTPase Inhibitors |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C28H24F3N7O2 |
| Formula Weight | 547.53 |
142
Tocris Bioscience™ Oxotremorine M
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 3854-04-4 Molecular Formula: C11H19IN2O
| CAS | 3854-04-4 |
|---|---|
| Molecular Formula | C11H19IN2O |
143
Tocris Bioscience™ LC 2 Epimer
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Negative control for LC 2 (Cat. No. 7420)
144
| CAS | 596-51-0 |
|---|---|
| Molecular Formula | C19H28BrNO3 |
145
Tocris Bioscience™ SJF 0628
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent BRAF PROTAC™
146
Tocris Bioscience™ LDN 193188
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Inhibitor of phosphatidylcholine transfer protein (PC-TP)
| Target | Lipid Metabolism Inhibitors |
|---|---|
| CAS | 1267610-30-9 |
| Purity | >99% |
| Chemical Name or Material | 2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C20H17Cl2N5O4S |
| Formula Weight | 494.35 |
147
Tocris Bioscience™ Propranolol hydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 3506-09-0 Molecular Formula: C17H24ClNO2
| CAS | 3506-09-0 |
|---|---|
| Molecular Formula | C17H24ClNO2 |
148
Tocris Bioscience™ AR-C 69931 Tetrasodium Salt
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Low molecular weight, organic compound that may help regulate biological process.
149
Tocris Bioscience™ DMXAA
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mSTING agonist; induces antitumor immunological responses
| Target | STING Agonists |
|---|---|
| CAS | 117570-53-3 |
| Purity | 99% |
| Chemical Name or Material | 5,6-Dimethyl-9-oxo-9 H-xanthene-4-acetic acid |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C17H14O4 |
| Formula Weight | 282.29 |
150
Tocris Bioscience™ 1R,3R-RSL3
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Negative control for 1S,3R-RSL3 (Cat. No. 6118)
| Target | Glutathione Peroxidase 4/GPX4 |
|---|---|
| CAS | 1219810-15-7 |
| Purity | 0.98 |
| Chemical Name or Material | (1 R,3 R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1 H-pyrido[3,4-b]indole-3-carboxylate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C23H21ClN2O5 |