Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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151
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165
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151
Tocris Bioscience™ Trofinetide
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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IGF-1 synthetic analogue
152
Tocris Bioscience™ TH 5427 Hydrochloride
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Potent NUDT5 inhibitor
| Purity | 98% |
|---|---|
| Chemical Name or Material | 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride |
| Recommended Storage | Desiccate at Room Temperature |
| Molecular Formula | C20H20Cl2N8O3.HCl |
| Formula Weight | 527.79 |
153
Tocris Bioscience™ CeMMEC1
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TAF1 inhibitor
| Target | Bromodomain Inhibitors |
|---|---|
| CAS | 440662-09-9 |
| Purity | 0.98 |
| Chemical Name or Material | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H16N2O4 |
154
Tocris Bioscience™ HC 030031
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 349085-38-7 Molecular Formula: C18H21N5O3
| CAS | 349085-38-7 |
|---|---|
| Molecular Formula | C18H21N5O3 |
155
Tocris Bioscience™ WZ 4002
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Potent mutant-selective EGFR inhibitor
| Target | EGF Receptor Inhibitors |
|---|---|
| CAS | 1213269-23-8 |
| Purity | 0.98 |
| Chemical Name or Material | N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C25H27ClN6O3 |
156
Tocris Bioscience™ Lenalidomide 4'-PEG2-amine
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Cereblon ligand with PEG linker and terminal amine for onward chemistry
157
Tocris Bioscience™ ALDH Detection Reagent - BAAA-DA
Fluorescent ALDH substrate and detection reagent. Used for: identification of cells with high ALDH activity. Application: flow cytometry, fluorescent-activated cell sorting (FACS)
158
Tocris Bioscience™ PF 06260933 dihydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
| Target | HGK/MAP4K4 |
|---|---|
| CAS | 1883548-86-4 |
| Purity | 98% |
| Chemical Name or Material | 5-(4-Chlorophenyl)-[3,3 '-bipyridine]-6,6 '-diamine dihydrochloride |
| Recommended Storage | Desiccate at Room Temperature |
| Synonym | EC 2.7.11, EC 2.7.11.1, FLH21957, FLJ10410, hepatocyte progenitor kinase-like/germinal center kinase-like kinase, HGKFLJ20373, HPK/GCK-like kinase HGK, KIAA0687, MAP4K4, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, MEKKK4, mitogen-activa |
| Molecular Formula | C16H13ClN40.2 HCl |
| Formula Weight | 369.68 |
159
Tocris Bioscience™ Click N-Acetylmuramic acid - azide
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes
160
Tocris Bioscience™ EMD 527040 hydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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ανβ6 integrin inhibitor
161
Tocris Bioscience™ SB 204990
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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ATP citrate lyase (ACLY) inhibitor
| Inhibitors | SB 204990 |
|---|---|
| Product Type | SB 204990 |
| Molecular Weight (g/mol) | 389.27 |
| Purity | >98% |
162
Tocris Bioscience™ PAG 4'-piperazine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Functionalized cereblon ligand for PROTAC development
163
Tocris Bioscience™ TTP 22
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CAS: 329907-28-0 Molecular Formula: C16H14N2O2S2
| CAS | 329907-28-0 |
|---|---|
| Molecular Formula | C16H14N2O2S2 |
164
Tocris Bioscience™ Pomalidomide 4'-PEG1-acid
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cereblon ligand with PEG linker and terminal acid for onward chemistry
165
Tocris Bioscience™ Conduritol B epoxide
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Irreversible glucocerebrosidase (β-glucosidase) inhibitor; used to generate Gaucher disease models
| Target | Glycosylase Inhibitors |
|---|---|
| CAS | 6090-95-5 |
| Chemical Name or Material | DL-1,2-Anhydro-myo-Inositol |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C6H10O5 |