Bioactive Small Molecules
Medchemexpress LLC HY-10095 2mg , Olcegepant CAS:204697-65-4 Purity:>98%
HY-10095 2mg Olcegepant CAS: 204697-65-4 Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Cisapride | 81098-60-4 | MFCD00868098 | >98.0% | 465.95 | C23H29ClFN3O4 | 5 MG
Cisapride is a gastroprokinetic agent and a research-standard 5-HT4 receptor agonist used in pharmacology and ion-channel studies. It is reported to block hERG channels and is supplied as a high-purity analytical standard for laboratory use (CAS 81098-60-4, formula C23H29ClFN3O4, MW 465.95).
- High purity (>98.0%) suitable for research and analytical applications.
- Orally active 5-HT4 receptor agonist for pharmacological assays.
- hERG blocker with reported IC50 ≈ 9.4 nM and 5-HT4 EC50 ≈ 140 nM.
- Available as a solid in small pack sizes for analytical testing.
- Molecular formula C23H29ClFN3O4; molecular weight 465.95.
Medchemexpress LLC GSK-J4 | 1373423-53-0 | 99.45% | 417.50 | 50 MG
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50s of 8.6 μM and 6.6 μM respectively. This cell-permeable proagent of GSK-J1 induces endoplasmic reticulum stress-related apoptosis and inhibits LPS-induced TNF-α production in human primary macrophages.
- Potent dual inhibitor of H3K27me3/me2-demethylases
- Inhibits LPS-induced TNF-α production in human primary macrophages
- Cell-permeable proagent
- Induces endoplasmic reticulum stress-related apoptosis
- Increases total nuclear H3K27me3 levels in untransfected cells
- Reduces Jagged-1 mRNA and protein levels
- Promotes differentiation of Treg cells
Medchemexpress LLC nor-NOHA monoacetate | 2250019-93-1 | 99.9% | 236.23 | 100 MG
nor-NOHA monoacetate is a selective and reversible arginase inhibitor. It induces apoptosis in ARG2-expressing cells under hypoxia and exhibits anti-leukemic activity. It can be utilized in studies concerning endothelial dysfunction, immunosuppression, and metabolism.
- Selective and reversible arginase inhibitor
- Induces apoptosis in ARG2-expressing cells under hypoxia
- Exhibits anti-leukemic activity
- Can be used in studies of endothelial dysfunction, immunosuppression, and metabolism
- Induces apoptosis in a dose-dependent manner in K562 cells under hypoxia
- Attenuates hypoxia-mediated resistance towards imatinib in K562 or KCL22 cells
- Induces a significant reduction of infarct size in male Sprague-Dawley rats
- Increases plasma citrulline and nitrite levels and decreases ornithine plasma levels in male Sprague-Dawley rats
Medchemexpress LLC D-a-tert-Butyl-Gly-OH | 26782-71-8 | 131.17 | 100 G
D-a-tert-Butyl-Gly-OH is a leucine derivative, categorized as an amino acid derivative. These compounds are utilized as ergogenic supplements, impacting anabolic hormone secretion, providing fuel during exercise, improving mental performance under stress, and aiding in the prevention of exercise-induced muscle damage. They are widely recognized as beneficial ergogenic dietary substances.
- Leucine derivative
- Functions as an ergogenic supplement
- Influences anabolic hormone secretion
- Supports fuel supply during physical activity
- Enhances mental performance during stress-related tasks
- Assists in preventing exercise-induced muscle damage
- Purity: ≥98.0%
- Molecular weight: 131.17
- Formula: C6H13NO2
- Appearance: Solid
- Color: White to off-white
- Solubility in H2O: 33.33 mg/mL (254.10 mM)
Medchemexpress LLC 7-(2-morpholin-4-ylethoxy)-4-(2-pyridin-2-yl-dihydropyrrolopyrazol-3-yl)quinoline | 700874-71-1 | 100.0% | 100 MG
LY2109761 is an orally active, small-molecule dual inhibitor of transforming growth factor-β (TGF-β) receptor types I and II used in preclinical research to block TGF-β/Smad signaling and study effects on tumor progression and cellular autophagy.
- Orally active dual inhibitor of TGF-β receptor type I and II.
- Ki values: TβRI = 38 nM, TβRII = 300 nM (cell-free assays).
- Molecular formula C26H27N5O2; molar mass ≈ 441.5 g·mol-1.
- Reported purity up to 99.99% by some vendors; intended for research use only.
- Used to study Smad2 phosphorylation, autophagy, apoptosis, and metastasis in preclinical models.
Medchemexpress LLC 3-Methyl-N-[4-(trifluoromethyl)phenyl]-2-benzofurancarboxamide | 588674-64-0 | C17H12F3NO2 | 25 MG
CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. It is used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).
- Inhibits the CCL20/CCR6 axis
- Blocks CCL20-induced CD4+ T cell migration
- Alleviates TNBS-induced inflammatory responses in mice
- Shows anti-inflammatory effects in Zymosan-induced peritonitis mice
Medchemexpress LLC Dynamin inhibitory peptide | 251634-21-6 | 96.1% | 1121.25 | 5 MG
Dynamin inhibitory peptide competitively blocks the binding of dynamin to amphiphysin, thus preventing endocytosis. It also blocks the dopamine D3 effect on GABAA receptors.
- Competitively blocks dynamin binding to amphiphysin, preventing endocytosis
- Blocks dopamine D3 effect on GABAA receptors
- Inhibits GABAAR endocytosis at 50 μM in vitro
Cayman Chemical Salvinorin A Carbamate, Purity: ≥90%, CAS: 858345-57-0, 5 mg
A potent KOR agonist; almost as potent as salvinorin A (EC50 = 6.2 and 4.5 nM for salvinorin A carbamate and salvinorin A, respectively); has increased biological stability compared to salvinorin A
Selleck Chemical LLC Auraptene S9052-1MG
Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties including anticarcinogenic anti-inflammatory antihelicobacter antigenotoxic and neuroprotective effects Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators including IL-6 IL-8 and chemokine (C-C motif) ligand-5(CCL5)
Medchemexpress LLC Sodium oleate | 143-19-1 | 304.44 | 25 G
Sodium oleate is an abundant monounsaturated fatty acid sodium and a Na+/K+ ATPase activator. It is the most common monounsaturated fatty acid (FA) in human adipocytes and other tissues. This compound promotes cell proliferation and migration in high metastatic cancer cells by enhancing β-oxidation mediated by AMPK activation. Conversely, it inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines.
- Abundant monounsaturated fatty acid sodium
- Na+/K+ ATPase activator
- Promotes cell proliferation and migration in high metastatic cancer cells
- Inhibits cancer cell growth and survival in low metastatic carcinoma cells
- For research use only
Medchemexpress LLC HY-136626 1mg Medchemexpress, Z-Ala-Ala-Asn-AMC CAS:149697-16-5 Purity:>98%
Medchemexpress, HY-136626 1mg Z-Ala-Ala-Asn-AMC CAS:149697-16-5 Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical 4A7C-301-Nurr1 Agonist, Purity: ≥98%, 5 mg
A Nurr1 receptor agonist; binds to Nurr1-LBD (IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively); decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in MPTP- or α-synuclein-overexpression mouse models of Parkinson’s disease
Cayman Chemical MK-0974, Purity: ≥98%, CAS: 781649-09-0, 5 mg
A CGRP receptor antagonist (Ki = 0.77 μM); binds selectively to the human CGRP receptor complex over the adrenomedullin receptor complexes in HEK293 cells (Kis = >100 and 29 μM for CRLR with RAMP2 and 3, respectively); inhibits CGRP-induced cAMP accumulation in HEK293 cells expressing the CGRP receptor complex (IC50 = 2.2 nM); reduces CGRP-induced vasodilation in isolated human meningeal arteries; inhibits vasodilation induced by topical application of capsaicin in rhesus monkeys (EC50 = 127 nM)
Cayman Chemical Tauro-Obeticholic Acid, Purity: ≥95%, CAS: 863239-61-6, 5 mg
An active metabolite of obeticholic acid; can be reconverted back to obeticholic acid by intestinal microflora