Bioactive Small Molecules
Medchemexpress LLC Ec144 | 911397-80-3 | 98.0% | C21H24ClN5O2 | 10MG
EC144 is a small-molecule Hsp90 inhibitor for research use, intended for preclinical and laboratory studies of cancer and Hsp90-mediated pathways. The compound is provided with characterization data and a safety data sheet for proper handling and storage.
- Inhibits heat shock protein 90 for mechanistic and pharmacology studies.
- High purity (98.0%) suitable for research applications.
- Defined molecular formula and weight aid in experimental planning.
- Soluble in DMSO for assay preparation.
- Supplied with SDS to support safe handling and storage.
Medchemexpress LLC Mal-di-EG-Val-Cit-PAB-MMAF | 98.6% | 1476.75 g·mol⁻¹ | C73H113N13O19 | 10 MG
MAL-di-EG-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) drug-linker conjugate that couples a cathepsin-cleavable Val-Cit-PAB linker to monomethyl auristatin F (MMAF), a potent tubulin polymerization inhibitor. It is supplied as a solid for use in ADC synthesis, conjugation studies, and preclinical research.
- Molecular formula: C73H113N13O19 (manufacturer SDS; alternate product page reports a different formula)
- Molecular weight: 1476.75 g·mol⁻¹ (manufacturer SDS; product page lists a different value)
- Purity: manufacturer product page reports ~98.6% (alternate data-sheet entry lists ~96.0%); verify batch certificate for exact lot purity
- Physical form: solid, unstable in solution; prepare fresh for use and store under recommended conditions
- Typical use: building block for antibody-drug conjugate synthesis and preclinical ADC research
- Available pack sizes: includes 10 MG; larger sizes available by quote
Cayman Chemical ASTX660, Purity: ≥98%, CAS: 1799328-86-1, 10 mg
A non-peptidomimetic inhibitor of IAP protein-peptide interactions; inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s = 50 = 2.8 nM); induces displacement of Smac from XIAP in A375 melanoma cells; induces apoptosis in MDA-MB-231, A375, and SK-MEL-28 cells in a TNF-α-dependent manner; reduces tumor growth in MDA-MB-231 and A375 mouse xenograft models at 20 mg/kg
Cayman Chemical NS 11021, Purity: ≥95%, CAS: 956014-19-0, 25 mg
Selectively activates BKCa channels, binding directly the ɑ subunit; relaxes intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact rats
![Medchemexpress LLC N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine | 443913-73-3 | MFCD07772346 | >98.0% | 475.35 g·mol⁻¹ | C22H24BrFN4O2 | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000246432.png-250.jpg)
Medchemexpress LLC N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine | 443913-73-3 | MFCD07772346 | >98.0% | 475.35 g·mol⁻¹ | C22H24BrFN4O2 | 500 MG
Vandetanib is a small-molecule tyrosine kinase inhibitor used in oncology research to study angiogenesis and tumor cell signaling. It is supplied as a research-grade solid with analytical purity suitable for in vitro and preclinical studies.
- Small-molecule tyrosine kinase inhibitor targeting VEGFR and EGFR.
- Research-grade white to off-white powder suitable for laboratory use.
- Typical purity ≥98.0% (HPLC).
- Molecular weight 475.35 g·mol⁻¹; formula C22H24BrFN4O2.
- Commonly supplied in 500 MG quantities for bench research.
Medchemexpress LLC Suc-AAPK-pNA | 108929-39-1 | 98.1% | 605.64 | 10 MG
Suc-AAPK-pNA is a chromogenic substrate used for determining serine/threonine kinase activity and enzyme kinetic parameters. This product is for research use only.
- Chromogenic substrate
- Used for determining serine/threonine kinase activity
- Used for determining enzyme kinetic parameters
- Intended for research use only
Apexbio Technology LLC U-73122 5mg. MFCD22683852.
U-73122 is a potent phospholipase C (PLC) inhibitor with IC50 value of ~6 μM. PLC is a class of membrane-associated enzymes that catalyzes the hydrolysis of a membrane phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP2), to produce two intracellular messengers, diacylglycerol and inositol-triphosphate, which, in turn, mediate the activation of protein kinase C (PKC) and intracellular Ca2+ release, respectively. It plays an important role in various signal transduction pathways. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Animal-Free IL-33 H 10ug
Animal-Free IL-33 Protein, Human (His) is a recombinant His-tagged fragment of human interleukin-33 (residues S112-T270) produced using an animal-free manufacturing process for in vitro research. It is supplied in research-scale sizes suitable for signaling and receptor interaction studies.
- Recombinant human IL-33 fragment (S112-T270) suitable for in vitro assays.
- C-terminal 6xHis tag for detection and purification.
- Produced under animal-free manufacturing conditions for high consistency.
- Available in small research sizes, including 10 μg.
- Intended for cell signaling, receptor binding, and functional cytokine assays.
Cayman Chemical IFN-α-IFNAR-IN-1 (hydrochloride), Purity: ≥98%, CAS: 2070014-98-9, 5 mg
An inhibitor of the IFN-α-IFNAR protein-protein interaction (Kd = 4 µM for binding to IFN-α); inhibits virus-induced increases in the production of IFN-α and IL-12 in BM-pDCs infected with MVA or VSV at 18 µM; reduces increases in IL-12 production induced by stimulation with CpG 2216 or poly(I:C) in the same cells
Medchemexpress LLC Taurohyodeoxycholic 50mg | 38411-85-7 | 50 MG
Taurohyodeoxycholic acid is an orally active 6α-hydroxylated bile acid used in preclinical research to modulate inflammatory responses and to study liver and intestinal disease models.
- Orally active 6α-hydroxylated bile acid used in biological studies.
- Modulates inflammatory markers such as MPO, TNF-α, and IL-6.
- High purity (99.7%) suitable for in vitro and in vivo assays.
- Soluble in DMSO at 100 mg/mL; multiple in vivo formulation protocols available.
- Stable when stored as powder at -20°C for extended periods.
Medchemexpress LLC HY-107428 5mg Medchemexpress, PD-166793 CAS:199850-67-4 Purity:>98%
Medchemexpress, HY-107428 5mg PD-166793 CAS:199850-67-4 PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 25 MG
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant Epidermal Growth Factor Receptor (EGFR). It induces degradation of EGFRdel19 and EGFRL858R/T790M mutations. This compound inhibits the growth of cancer cell lines (e.g., HCC827, H1975), with its EGFR degradation linked to autophagy.
- Potent degrader of mutant EGFR.
- Induces degradation of specific EGFR mutations (EGFRdel19 and EGFRL858R/T790M).
- Inhibits growth of specific cancer cell lines.
- Its degradation mechanism is related to autophagy.
- Displays antiproliferative activity against various cancer cells, including those expressing wild-type EGFR.
- Reduces phosphorylation of EGFR and its downstream effector Akt.
- Induces apoptosis and G1 phase arrest in cancer cell lines.
Medchemexpress LLC Trans-Benzylideneacetone | 1896-62-4 | 99.87% | 146.19 | 1 G
trans-Benzylideneacetone (trans-Benzalacetone) is a metabolite of the gram-negative entomopathogenic bacterium *Xenorhabdus nematophila*. It acts as an enzyme inhibitor against phospholipase A2 (PLA2) and is also an immunosuppressant, intended for research use only.
- High purity of 99.87%.
- Inhibits phospholipase A2 (PLA2) activity.
- Acts as an immunosuppressant.
- Suitable for various *in vitro* and *in vivo* research protocols.
- Store at 4°C, protected from light.
Cayman Chemical I-BET726, Purity: ≥98%, CAS: 1300031-52-0, 1 mg
A selective inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively); inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines, in vitro and in vivo
Medchemexpress LLC Tau peptide (273-284) | 1663490-91-2 | 98.8% | 1368.66 | 10 MG
Tau Peptide (273-284) is a Tau fragment designed for research in tauopathies, particularly Alzheimer's disease. This peptide is for research use only and not intended for patient treatment. In vitro studies show that Tau Peptide (273-284) (50 μM) forms β-structures faster in the ΔK280 mutant compared to its wild-type counterpart.
- Used in research of tauopathies
- Forms β-structures faster in ΔK280 mutant
- White to off-white solid appearance
- Available in various pack sizes