Bioactive Small Molecules
Selleck Chemical LLC 13-Dicaffeoylquinic acid S9512-1MG
1 3-Dicaffeoylquinic acid (Cynarin Cinarine 1 5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke It shows antioxidant and choleretic properties and is a potential immunosuppressive agent
TARGETMOL CHEMICALS INC TASIMELTEON 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. purity: 99%
Cayman Chemical ANTIBODY Monastrol 5mg
A reversible, cell-permeable inhibitor of the motor protein Eg5, blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM)
Cayman Chemical ANTIBODY OleamIde 100mg
An amide of oleic acid and agonist of CB1 receptors (Ki = 8.13 µM); selective for CB1 over CB2 receptors, where it inhibits binding of the CB receptor full agonist CP55,940 by only 42.5% in HEK-293T cells expressing human CB2 receptors at 100 µM; inhibits forskolin-induced cAMP accumulation in N1E 115 mouse neuroblastoma cells; induces physiological sleep in rats at 5-50 mg; increases food intake in rats and anxiolytic-like effects in group-housed and socially isolated mice; induces transactivation of PPARα, PPARβ, and PPARγ; inhibits SERCA
Cayman Chemical ANTIBODY Irbesartn 10mg
An insurmountable AT1 receptor antagonist (Ki = 1.3 nM); reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet at 3, 10, and 30 mg/kg; reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using ApoE-knockout mice with diabetes induced by STZ
Cayman Chemical THAL-SNS-032 10mg
A PROTAC that drives Cdk9 degradation; selectively induces degradation of Cdk9 over Cdk1, Cdk2, and Cdk7 in MOLT-4 cells at 250 nM; inhibits HCMV replication in infected HFFs (EC50s = 0.025 µM); inhibits viral replication in murine CMV-infected MEFs (EC50 = 0.22 µM)
Cayman Chemical PF-06869206 5mg
An NaPi2a inhibitor (IC50 = 380 nM); selective for NaPi2a over NaPi2b, NaPi2c, PiT-1, and PiT-2 (IC50s = >25 μM)
![Medchemexpress LLC 8-quinolinol, 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]- | 446826-86-4 | 98.1% (HPLC) | 449.47 g/mol | C24H17F2N3O2S | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237516.png-250.jpg)
Medchemexpress LLC 8-quinolinol, 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]- | 446826-86-4 | 98.1% (HPLC) | 449.47 g/mol | C24H17F2N3O2S | 5MG
KIN1400 is a small-molecule research compound that functions as a potent IRF3 activator, inducing IRF3-dependent innate antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and increasing IFN-β expression. It has reported activity against West Nile virus, dengue virus, and hepatitis C virus, acting through a MAVS-IRF3 signaling axis and suitable for in vitro antiviral and innate immunity studies.
- Potent IRF3 activator that induces innate antiviral gene expression.
- Reported inhibition of WNV, DV, and HCV replication.
- Engages RIG-I and MDA5 pathways and elevates IFN-β levels.
- Small-molecule format intended for in vitro research applications.
- Molecular formula C24H17F2N3O2S; molecular weight 449.47 g/mol.
- Purity 98.1% (HPLC) as reported on batch certificate of analysis.
- Available in small research quantities suitable for assay development.
Cayman Chemical -FunaltrexamInhydrochlorI 5mg
A μ- and κ1-opioid receptor antagonist (Kis = 0.3 and 0.2 nM, respectively); selective for μ- and κ1-opioid receptors over the δ-opioid receptor (Ki = 12.8 nM); reversibly inhibits electricity-induced twitches of isolated guinea pig ileal longitudinal muscle strips (IC50 = 48 nM), indicating opioid agonist activity; inhibits endomorphin 1-induced conditioned place preference in mice at 0.3 UG/animal, i.c.v.; prevents decreases in urine output induced by fentanyl, D-propoxyphene, buprenorphine, profadol, or bromadoline in water-loaded rats at 40 mg/kg; reduces hemokinin 1-induced increases in the latency to withdrawal in the tail-flick test in mice
AdipoGen Ursodeoxycholic acid (1 g)
Chemical. CAS: 128-13-2. Formula: C24H40O4. MW: 392.6. Synthetic. Endogenous hydrophilic bile acid. Antioxidant. Cytoprotective against oxidative stress and cell death. Hepatoprotective at cellular and molecular level, including stabilization of membranes. Protects hepatocytes against bile acid-induced apoptosis. Antiapoptotic and antinecrotic. Targets the mitochondrial function and integrity, reduction of endoplasmatic stress and interactions with survival signals in cAMP, Akt, NF-kappaB, MAPK and PI3K signaling pathways. Modulator and finetuner of the p53-Mdm-2 complex. Chemopreventive against colorectal cancer by countering the tumor-promoting effects of secondary bile acids. Shows also effects on epidermal growth factor receptor (EGFR) signaling and COX-2 expression. Immunomodulator and anti-inflammatory compound. Modifies TLR4 and TLR9 signaling pathways and downregulates the production of proinflammatory tumor necrosis factor-alpha (TNF-alpha).
Cayman Chemical ANTIBODY MK-8617 50mg
A HIF-PH1, -2, and -3 inhibitor (IC50s = 1, 1, and 14 nM, respectively); selective for HIF-PH1, -2, and -3 over various CYPs (IC50s = >1.6 µM for all) and FIH (IC50 = 18 µM), as well as over a panel of 171 enzymes at 10 µM; increases serum levels of EPO and hemoglobin, as well as the number of circulating red blood cells, in rats
Cayman Chemical ANTIBODY ErIbulIn 10mg
An inhibitor of microtubule assembly; inhibits the proliferation of U937 human lymphoma cells, as well as induces cell cycle arrest at the G2/M phase and, subsequently, apoptosis in the same cells at 100 nM; reduces tumor growth in a PDX mouse model of cutaneous squamous cell carcinoma at 1.5 mg/kg per week; reduces tumor growth and increases survival in an intracerebral U87MG mouse xenograft model of glioblastoma at 0.5 mg/kg three times per week
Medchemexpress LLC Dehydroandrographolide succinate | 786593-06-4 | 532.58 | 25 MG
Dehydroandrographolide succinate | 786593-06-4 | 532.58 | 25 MG