Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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1,021
Tocris Bioscience™ LY 379268 disodium salt
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Sodium salt of LY 379268 (Cat. No. 2453); selective group II mGlu receptor agonist
| Inhibitors | LY 379268 disodium salt |
|---|---|
| Product Type | LY 379268 disodium salt |
| Molecular Weight (g/mol) | 231.11 |
| Purity | >98% |
1,022
Tocris Bioscience™ GR 127935 hydrochloride
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CAS: 148642-42-6 Molecular Formula: C29H32ClN5O3
| CAS | 148642-42-6 |
|---|---|
| Molecular Formula | C29H32ClN5O3 |
1,023
Tocris Bioscience™ (S)-AMPA
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CAS: 83643-88-3 Molecular Formula: C7H10N2O4
| CAS | 83643-88-3 |
|---|---|
| Molecular Formula | C7H10N2O4 |
1,024
Tocris Bioscience™ LYN 1604 dihydrochloride
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Potent UNC-51-like kinase 1 (ULK1) agonist
| Target | ULK1 |
|---|---|
| CAS | 2310109-38-5 |
| Chemical Name or Material | 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride |
| Recommended Storage | Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. |
| Molecular Formula | C33H43Cl2N3O2.2HCl |
1,025
Tocris Bioscience™ GSK 2830371
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Potent and selective allosteric inhibitor of Wip1 phosphatase
| Inhibitors | GSK 2830371 |
|---|---|
| Product Type | GSK 2830371 |
| Molecular Weight (g/mol) | 461.02 |
| Purity | >98% |
1,026
Tocris Bioscience™ SJ 1008030
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective JAK2 Degrader (PROTAC™)
1,027
Tocris Bioscience™ THDOC
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Positive modulator of GABAA receptors; endogenous neurosteroid
1,028
Tocris Bioscience™ RAGE 229
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ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice
1,029
Tocris Bioscience™ Rilmenidine hemifumarate
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α2 agonist. Also I1 ligand
| CAS | 207572-68-7 |
|---|---|
| Purity | 0.98 |
| Chemical Name or Material | 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C10H16N2O.½C4H4O4 |
| Formula Weight | Observed MW: 238.29 |
| Assay Percent Range | >99% |
1,030
Tocris Bioscience™ Cyanine 5 Tyramide
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Red fluorescent reagent widely used for signal amplification in IHC and FISH
1,031
Tocris Bioscience™ LC 2
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Selective KRAS PROTAC™
1,032
Tocris Bioscience™ iP300w
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Potent p300/CBP inhibitor
1,033
Tocris Bioscience™ GI 530159
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TREK1 and TREK2 channel activator
| Product Type | Channel Activator |
|---|---|
| Purity | 99% |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C27H20F6N2O2 |
| Formula Weight | 518.45 |
1,034
Tocris Bioscience™ Arbidol
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Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
1,035
Tocris Bioscience™ TP 238
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CECR2 and BPTF/FALZ inhibitor