Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Color
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Quantity
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121
Tocris Bioscience™ SM 16
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent TGF-β receptor type 1 (TGF-βRI) inhibitor
122
Tocris Bioscience™ BRD 73954
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Dual histone deacetylase (HDAC) 6/8 inhibitor
| CAS | 1440209-96-0 |
|---|---|
| Chemical Name or Material | N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C16H16N2O3 |
| Formula Weight | Observed MW: 284.31 |
| Assay Percent Range | >98% |
123
Tocris Bioscience™ O-Propargyl-puromycin
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Puromycin analog for labeling newly synthesized proteins; is incorporated into nascent polypeptides
124
Tocris Bioscience™ LC 2
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective KRAS PROTAC™
125
Tocris Bioscience™ CG 428
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent tropomyosin receptor kinase (TRK) degrader
126
Tocris Bioscience™ Pomalidomide 4'-alkylC5-azide
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cereblon ligand with alkyl linker and terminal azide for onward chemistry
127
Tocris Bioscience™ DA ZP1
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Fluorogenic Zn(II) sensor for isolation of stem cell derived β cells
128
Tocris Bioscience™ SCOTfluor lactic acid probe 510
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Fluorescent lactic acid probe
129
Tocris Bioscience™ CG 858-Neg
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Negative control for CG 858 (Cat. No. 7427)
130
Tocris Bioscience™ SIM1
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective trivalent BET Bromodomain Degrader (PROTAC™)
131
Tocris Bioscience™ Pomalidomide 4'-alkylC3-azide
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cereblon ligand with alkyl linker and terminal azide for onward chemistry
132
Tocris Bioscience™ CG 858
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective BRAF-V600E protein Degrader (uSMITE™)
133
Tocris Bioscience™ Cediranib
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent inhibitor of VEGFR, PDGFR and FGFR
| Target | VEGF Receptor Inhibitors |
|---|---|
| CAS | 288383-20-0 |
| Purity | 0.98 |
| Chemical Name or Material | 4-[(4-Fluoro-2-methyl-1 H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C25H27FN4O3 |
134
Tocris Bioscience™ Ac4ManNAz
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe
135
Tocris Bioscience™ MRTX 849
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Mutation-selective inhibitor of KRASG12C
| Target | Ras GTPase Inhibitors |
|---|---|
| CAS | 2326521-71-3 |
| Purity | 98% |
| Chemical Name or Material | 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C32H35ClFN7O2 |