Crosslinking Reagents
TARGETMOL CHEMICALS INC Lys-SMCC-DM1 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Lys-SMCC-DM1 (Lys-N-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.
Cayman Chemical Sulfo-SMCCsodIum salt 100mg
A peptide agonist of GnRH binds to GnRHR (Ki 0 1 nM) decreases testicular volume semen volume sperm motility and total sperm count as well as increases the percentage of abnormal sperm in dogs via a subcutaneous implant at 3 6 and 12 mg per animal decreases disease severity and plasma levels of estradiol 17-hydroxyprogesterone and androstenedione in ferrets with ACD at 3 mg/implant per animal suppresses ovulation and estrus in cats at 4 7 mg/implant per animal
Cayman Chemical SulfosuccInImIdyl 32 BIot 10mg
An inhibitor of the USP1-UAF complex (IC50 0.544 UM for its deubiquitinase activity) and SARS-CoV-2 PLpro (IC50s 0.56 and 0.091 UM using Z-LRGG-AMC or Ub-AMC respectively as PLpro substrates) reduces the levels of USP1 ID-1 ID-2 and ID-3 in K562 cells at 0.5-10 UM decreases the viability of K562 cells (EC50 1.07 UM) induces apoptosis in K562 cells in a concentration-dependent manner
Cayman Chemical SulfosuccInImIdyl 32 BIot 25mg
An inhibitor of the USP1-UAF complex (IC50 0.544 UM for its deubiquitinase activity) and SARS-CoV-2 PLpro (IC50s 0.56 and 0.091 UM using Z-LRGG-AMC or Ub-AMC respectively as PLpro substrates) reduces the levels of USP1 ID-1 ID-2 and ID-3 in K562 cells at 0.5-10 UM decreases the viability of K562 cells (EC50 1.07 UM) induces apoptosis in K562 cells in a concentration-dependent manner
Cayman Chemical OlIvetolIc AcId 50mg
A non-selective inhibitor of CaCCs blocks ATP-stimulated chloride conductance in human salivary gland intestinal and bronchial epithelial cells (mean IC50 10 UM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride attenuates CaCC TMEM16-A-induced proliferation in cancer cell lines reduces KCa1.1/BK channel activity in human red blood cells
Cayman Chemical ArtemIsInIc AcId 50mg
An agonist of RAR isoforms (EC50s 77 35 and 4 nM for RARa RARa and RARY respectively) induces growth arrest of MCF-7 and NB4 cells in vitro a natural metabolite of vitamin A
Cayman Chemical EZ-LocostatIn 50mg
An inhibitor of MMP-1 MMP-2 and MMP-3 (IC50s 1 3 30 and 150 M respectively) selective for MMP-1 MMP-2 and MMP-3 over the proteases thermolysin urease trypsin a-chymotrypsin plasmin and elastase (4 mM)
Cayman Chemical LognIc AcId 50mg
An acaricide provides 100 control of mites when used at a concentration of 25 ppm a positive allosteric modulator of GABA receptors containing the Rdl subunit homolog TuGABAR in T urticae (spider mites) shifting the GABA-induced response from an EC50 value of 24 8 to 4 83 UM when used at a concentration of 30 UM
Cayman Chemical N-Hydroxysulfosuccinimide so
A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes molds yeasts dimorphic fungi and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki 68 nM IC50 270 nM)
Cayman Chemical DIsuccInImIdyl Glutarate 25mg
A dual inhibitor of EGFR and HER2 (IC50s 92 and 59 nM respectively) selective for EGFR and HER2 over a panel of 12 kinases (IC50s 5000 nM) but does inhibit VEGFR2 and Src (IC50s 800 and 1400 nM respectively) inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s 0 2-3 nM) reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models at 40 mg/kg
Cayman Chemical 1 7-DImethylurIc AcId 50mg
A synthetic derivative of staurosporine that inhibits a variety of kinases including Akt protein kinase C (IC50 30 nM) PDK1 (IC50 6 nM) and cyclin-dependent kinases (IC50s 300-600 nM for Cdk1 and Cdk2) arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase Chk1 (IC50 7 nM) leading to apoptosis