Crosslinking Reagents
Cayman Chemical LognIc AcId 50mg
An acaricide provides 100 control of mites when used at a concentration of 25 ppm a positive allosteric modulator of GABA receptors containing the Rdl subunit homolog TuGABAR in T urticae (spider mites) shifting the GABA-induced response from an EC50 value of 24 8 to 4 83 UM when used at a concentration of 30 UM
Cayman Chemical EZ-LocostatIn 50mg
An inhibitor of MMP-1 MMP-2 and MMP-3 (IC50s 1 3 30 and 150 M respectively) selective for MMP-1 MMP-2 and MMP-3 over the proteases thermolysin urease trypsin a-chymotrypsin plasmin and elastase (4 mM)
Cayman Chemical Sulfo-SMCCsodIum salt 100mg
A peptide agonist of GnRH binds to GnRHR (Ki 0 1 nM) decreases testicular volume semen volume sperm motility and total sperm count as well as increases the percentage of abnormal sperm in dogs via a subcutaneous implant at 3 6 and 12 mg per animal decreases disease severity and plasma levels of estradiol 17-hydroxyprogesterone and androstenedione in ferrets with ACD at 3 mg/implant per animal suppresses ovulation and estrus in cats at 4 7 mg/implant per animal
Cayman Chemical DIsuccInImIdyl Suberate 500mg
A potent inhibitor of DGAT-1 (IC50s 7 and 24 nM for human and mouse respectively) confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice
Cayman Chemical CInabarInIc AcId 50mg
Pnolenc acd s a PUFA found n Korean pne (Pnus orentals) and martme pne (Pnus pnaster) seed ols Both ols have been found to have lpd-lowerng propertes A det contanng martme pne seed ol (MPSO) lowered HDL and ApoA1 levels n transgenc mce expressng human ApoA1 MPSO was found to dmnsh cholesterol efflux n vtro 14273 Korean pne seed ol supplements may help n obesty by reducton of appette People takng ths ol had an ncrease n the satety hormones CCK and GLP-1 and a reduced desre to eat 14280 The actvty of the ol s attrbuted to pnolenc acd Pnolenc acd s not converted to arachdonc acd metabolcally and can reduce arachdonc acd levels n the phosphatdylnostol fracton of Hep-G2 cells from 15 9 to 7 0 8724
Cayman Chemical 1 7-DImethylurIc AcId 50mg
A synthetic derivative of staurosporine that inhibits a variety of kinases including Akt protein kinase C (IC50 30 nM) PDK1 (IC50 6 nM) and cyclin-dependent kinases (IC50s 300-600 nM for Cdk1 and Cdk2) arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase Chk1 (IC50 7 nM) leading to apoptosis
Cayman Chemical N-Hydroxysulfosuccinimide so
A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes molds yeasts dimorphic fungi and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki 68 nM IC50 270 nM)
Cayman Chemical DIsuccInImIdyl Glutarate 25mg
A dual inhibitor of EGFR and HER2 (IC50s 92 and 59 nM respectively) selective for EGFR and HER2 over a panel of 12 kinases (IC50s 5000 nM) but does inhibit VEGFR2 and Src (IC50s 800 and 1400 nM respectively) inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s 0 2-3 nM) reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models at 40 mg/kg
Cayman Chemical 12-keto LIthocholIc AcId 50mg
A prodrug form of VRT-043198 inhibits LPS-induced increases in serum IL-1B levels in mice at 50 100 and 200 mg/kg reduces oxazolone-induced ear edema and levels of IL-1B IL-18 and IFN-Y in ear tissue in an oxazolone-sensitized mouse model of delayed-type hypersensitivity reduces forepaw inflammation in a mouse model of collagen-induced arthritis in a dose-dependent manner decreases seizure duration and the number of seizures in a mouse model of acute seizures induced by hippocampal kainic acid injection at 50 mg/kg as well as delays the onset of seizures at 100 and 200 mg/kg reduces the aggregated duration of epileptic activity in a mouse model of chronic epilepsy
Cayman Chemical TrIcosnoIc AcId 50mg
An inhibitor of P-gp selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel reverses P-gp efflux increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel
Cayman Chemical SulfosuccInImIdyl 32 BIot 10mg
An inhibitor of the USP1-UAF complex (IC50 0.544 UM for its deubiquitinase activity) and SARS-CoV-2 PLpro (IC50s 0.56 and 0.091 UM using Z-LRGG-AMC or Ub-AMC respectively as PLpro substrates) reduces the levels of USP1 ID-1 ID-2 and ID-3 in K562 cells at 0.5-10 UM decreases the viability of K562 cells (EC50 1.07 UM) induces apoptosis in K562 cells in a concentration-dependent manner
Cayman Chemical SulfosuccInImIdyl 32 BIot 25mg
An inhibitor of the USP1-UAF complex (IC50 0.544 UM for its deubiquitinase activity) and SARS-CoV-2 PLpro (IC50s 0.56 and 0.091 UM using Z-LRGG-AMC or Ub-AMC respectively as PLpro substrates) reduces the levels of USP1 ID-1 ID-2 and ID-3 in K562 cells at 0.5-10 UM decreases the viability of K562 cells (EC50 1.07 UM) induces apoptosis in K562 cells in a concentration-dependent manner
Cayman Chemical C-ReactIve ProteInhumnre 200ug
A DOT1L inhibitor (IC50 0.11 nM) selective for DOT1L over a panel of additional histone methyltransferases at 5 UM
Advanced Biomatrix PhotoHA-LAP Methacrylated Hyaluronic Acid + LAP Kit
Advanced BioMatrix offers PhotoHA, a methacrylated hyaluronic acid (HA) for photocrosslinkable hydrogels. These hydrogels provide native-like 3D HA gels with the unique attributes to be prepared at various concentrations and photocrosslinked to provide various gel stiffness. The kit comes with 100 mg of lyophilized methacrylated hyaluronic acid and 100 mg of LAP photoinitiator (405 nm blue light photocrosslinking). Hyaluronic acid is the most abundant glycosaminoglycan in the body being an important component of several tissues throughout the body. While it is abundant in extracellular matrices, hyaluronic acid also contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions.