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Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
An LTB4 receptor antagonist (Ki = 2 µM); inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s = 10 and 7 µM, respectively); inhibits bronchoconstriction induced by LTB4 in rats by 46%
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A PAK1 inhibitor (IC50 = 0.33 nM); selective for PAK1 over a panel of 117 kinases at 100 nM; binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively); inhibits S. enterica infection in HAP1 cells at 10 µM; inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils (IC50 = 59 nM)
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A metabolite of caffeine; scavenges hydroxyl radicals in a cell-free assay at 500 µM; inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes
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Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sulfo-SMCC sodium is a commonly used hetero-bifunctional non-cleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups respectively. purity: 99%
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A triterpene saponin with diverse biological activities; cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively); induces hot plate analgesia in mice (ED50 = 20.7 mg/kg); reduces arachidonic acid- or TPA-induced EAr edema in mice when administered at 0.7 and 1.6 mg/ear, respectively
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