Protein Modification Reagents
Medchemexpress LLC TCO-PEG5-maleimide | 00-00-0 | 99.5% | 583.67 g/mol | C28H45N3O10 | 5 MG
TCO-PEG5-maleimide is a PEG-based PROTAC linker and click-chemistry reagent containing a trans-cyclooctene (TCO) group that reacts via inverse electron-demand Diels-Alder (iEDDA) with tetrazine-functionalized partners. It also features a maleimide moiety for thiol conjugation and is supplied as a high-purity solid in small research pack sizes.
- Contains a trans-cyclooctene (TCO) reactive group for inverse electron-demand Diels-Alder (iEDDA) click reactions.
- Includes a PEG5 spacer to enhance solubility and linker flexibility.
- Features a maleimide group for selective conjugation to thiol groups.
- Offered as high-purity material (reported ~99.5%).
- Available in small milligram pack sizes suitable for research use.
- Store sealed at -20°C; in solvent, store at -80°C for long-term stability.
Medchemexpress LLC Cyclooct-4-en-1-yl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)carbamate | 1800507-93-0 | 95.0% | C17H32N2O5 | 10MG
TCO-PEG3-amine is a trans-cyclooctene (TCO)-functionalized PEG3 linker terminating in a primary amine, designed for bioconjugation and linker assembly in targeted degrader and chemical biology workflows. It combines a hydrophilic PEG spacer with a fast-reacting TCO handle for bioorthogonal labeling and a free amine for conventional coupling chemistries.
- Provides a trans-cyclooctene handle for rapid bioorthogonal click reactions.
- Contains a PEG3 spacer to improve solubility and reduce steric hindrance.
- Features a terminal primary amine for amide bond formation and conjugation.
- Suitable for PROTAC linker assembly, bioconjugation, and labeling applications.
- Offered as a high-purity research reagent with defined molecular properties.
Medchemexpress LLC Dota-PEG5-azide | 00-00-0 | 98.0% | C28H52N8O12 | 10MG
DOTA-PEG5-azide is a PEG-based linker that combines a DOTA chelator with an azide functional group for click-chemistry conjugation. Supplied as a white to off-white solid, it is intended for use in PROTAC synthesis, bioconjugation, and radiolabeling workflows where a chelator and a click-reactive handle are required.
- Contains DOTA chelator suitable for metal chelation and radiolabeling.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- PEG5 spacer improves solubility and reduces steric hindrance in conjugates.
- High purity (98.0%) for research-grade synthesis.
- Available in small-scale quantities compatible with iterative synthesis workflows.
Medchemexpress LLC Mal-amide-PEG2-oxyamine | 2253965-09-0 | 96.8% | 315.32 g/mol | C13H21N3O6 | 5 MG
Mal-amide-PEG2-oxyamine is a PEG-based bifunctional linker for assembling PROTACs and other bioconjugates. It features a maleimide amide and an oxyamine separated by a PEG2 spacer, permitting orthogonal thiol and oxime ligations. Supplied as a high-purity research reagent in milligram quantities.
- Contains maleimide and oxyamine functional groups for orthogonal conjugation.
- PEG2 spacer improves solubility and provides flexible linkage.
- Designed for PROTAC synthesis and targeted bioconjugation applications.
- High purity (96.8%) supports reproducible synthetic chemistry.
- Available in small milligram pack sizes suitable for research.
- Store pure material at -20°C for long-term stability.
Medchemexpress LLC Methyltetrazine-PEG8-NHS ester | 2183440-34-6 | MFCD31580145 | 99.3% | C32H47N5O13 | 10MG
Methyltetrazine-PEG8-NHS ester is a PEG-based linker bearing a methyltetrazine group and an N-hydroxysuccinimide (NHS) activated ester. It enables rapid bioorthogonal conjugation via inverse electron-demand Diels-Alder chemistry on the tetrazine side and efficient amine coupling through the NHS ester, making it suitable for PROTAC assembly and general bioconjugation in research applications.
- Methyltetrazine reactive handle enables fast bioorthogonal cycloaddition.
- NHS ester allows straightforward amine conjugation under mild conditions.
- PEG8 spacer improves aqueous solubility and reduces steric hindrance.
- High purity supports reliable synthetic and bioconjugation workflows.
- Compatible with linker assembly and PROTAC synthesis workflows.
Medchemexpress LLC 17-azido-3,6,9,12,15-pentaoxaheptadecyl 4-methylbenzenesulfonate | 906007-10-1 | MFCD29918254 | 98.6% | C19H31N3O8S | 10MG
Azide-PEG6-Tos is an azide-functionalized PEG6 tosylate linker for bioconjugation and PROTAC synthesis. It supplies an azide reactive handle and a tosyl leaving group for downstream functionalization, facilitating click chemistry and linker assembly in small-molecule and bioconjugate research.
- High purity of 98.6% suitable for synthetic applications.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- Tosylate leaving group allows facile nucleophilic substitution and modification.
- PEG6 spacer provides flexibility and improves solubility in polar solvents.
- Liquid form, colorless to light yellow, for easy handling and dosing.
- Stable when stored under recommended conditions to maintain integrity.
- Available in small milligram sizes for discovery and linker development.
Medchemexpress LLC Dota-peg5-c6-dbco | 00-00-0 | 96.3% | C49H71N7O14 | 10MG
DOTA-PEG5-C6-DBCO is a heterobifunctional PEG-based linker that combines a DOTA chelator with a DBCO moiety for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC). Supplied as a high-purity solid, it is designed for bioconjugation, PROTAC linker synthesis, and preparation of radiometal-labeled conjugates where chelation and bioorthogonal coupling are required.
- Heterobifunctional linker with DOTA chelator and DBCO reactive group.
- Enables copper-free SPAAC click conjugation to azide-functionalized molecules.
- Suitable for radiometal chelation and preparation of labeled conjugates.
- High purity (96.3%).
- Solid powder format with recommended storage at -20°C.
- Available in small batch sizes (5 mg-200 mg, larger quantities by quote).
NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 100mg | 649281217](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480345.JPG-250.jpg)
eMolecules DBCO-PEG-Silane, MW 1,000 | Broadpharm |652.864 | C34H48N4O7Si | 0.000 | CCO[Si](CCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 100mg | 649281217
DBCO-PEG-Silane, MW 1,000 | Broadpharm |652.864 | C34H48N4O7Si | 0.000 | CCO[Si](CCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 100mg | 649281217
Kyfora Bio DSPE 25 MG
DSPE (1,2-Distearoyl-rac-glycero-3-Phosphatidylethanolamine) is a saturated zwitterionic phospholipid and a derivative of phosphatidylethanolamine. It can be used in liposomal drug and gene delivery formulations. DSPE can be conjugated with PEG or PCB to develop stealth liposomes that have extended circulation time in the bloodstream.Key application(s): LNP, stealth liposomes