Protein Modification Reagents
eMolecules PEG3-Tos | 77544-68-4 | MFCD22574797 | 10g
Broadpharm | PEG3-Tos | 10g | 550803903 | BP-20909 | 98.000 | 77544-68-4 | MFCD22574797 | 260.300 | C11H16O5S
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Medchemexpress LLC DBCO-PEG2-acid | 2304558-25-4 | >=95.0% | C26H28N2O6 | 50 MG
DBCO-PEG2-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs themselves are composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, allowing PROTACs to exploit the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features a DBCO group for SPAAC
- Reacts with azide-containing molecules
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-Mal-N-bis(PEG4-NH-Boc) | 2128735-27-1 | 97.0% | C37H66N4O15 | 100 MG
N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker, intended for research use only. This compound can be utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Suitable for PROTAC synthesis
- Supports the study of PROTACs that selectively degrade target proteins
- For research use only
- Exhibits in vitro biological activity
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-OH | 2055041-39-7 | MFCD29918232 | 96.9% | 706.78 g/mol | C33H50N6O11 | 50 MG
Mal-PEG4-Val-Cit-PAB-OH is a cleavable four-unit polyethylene glycol (PEG) linker used to connect an antibody and a cytotoxic payload in antibody-drug conjugate (ADC) synthesis. It contains a maleimide reactive group for thiol coupling, a PEG4 spacer, a Val-Cit protease-cleavable dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer that enables intracellular release of payloads.
- Cleavable four-unit PEG linker enabling protease-mediated release.
- Maleimide functional group for thiol conjugation.
- Val-Cit dipeptide designed for cathepsin B cleavage.
- PAB self-immolative spacer to promote efficient payload release.
- Suitable for ADC synthesis and bioconjugation workflows.
eMolecules BIS-BIOTIN-PEG23 | AstaTech | 293298-36-9 | | 600.790 | C26H44N6O6S2 | 95.000 | O=C(CCCCC1SCC2NC(=O)NC12)NCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC12 | 10mg | 870091666
BIS-BIOTIN-PEG23 | AstaTech | 293298-36-9 | | 600.790 | C26H44N6O6S2 | 95.000 | O=C(CCCCC1SCC2NC(=O)NC12)NCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC12 | 10mg | 870091666
Broadpharm Iodoacetamido-PEG6-azide| 100mg| 1240737-77-2| Purity 98%
Iodoacetamido-PEG6-azide| 100mg| 1240737-77-2| Purity 98%
Medchemexpress LLC DOTA-PEG5-C6-DBCO | 97.9% | C49H71N7O14 | 25 MG
DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs consist of two ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein, utilizing the intracellular ubiquitin-proteasome system for selective protein degradation. This product is for research use only.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group for SPAAC with azide groups
- Molecular weight of 982.13
- Chemical formula C49H71N7O14
- Off-white to light yellow solid appearance
- High purity of 97.9%
Medchemexpress LLC NH2-C5-PEG4-N3-L-lysine-PEG3-N3 | 99.4% | 619.71 | C25H49N9O9 | 50 MG
NH2-C5-PEG4-N3-L-lysine-PEG3-N3 is a cleavable 7-unit PEG antibody-drug conjugate (ADC) linker containing an azide functional group, intended for research use in click chemistry conjugations. It facilitates attachment of payloads to biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC).
- Cleavable 7-unit PEG linker suitable for ADC synthesis.
- Azide functional group for CuAAC and SPAAC click reactions.
- High purity (≈99.4%).
- Water soluble: ≥100 mg/mL.
- Appearance: colorless to light yellow liquid.
- Recommended storage: pure form at -20°C.
- Packaged in 50 mg units.
Medchemexpress LLC Boc-NH-PEG4-C2-Boc | 2138484-13-4 | 421.53 | 25 MG
Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). These molecules are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs feature two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands connected by a linker
- Targets an E3 ubiquitin ligase
- Targets a specific protein
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC Biotin-PEG2-alkyne | 2227450-68-0 | MFCD31922733 | 95.6% | 369.48 g/mol | C17H27N3O4S | 250 MG
Biotin-PEG2-alkyne is a short polyethylene glycol (PEG) linker bearing a biotin affinity tag and a terminal alkyne for click chemistry. It is supplied as an off-white to light yellow solid with approximately 95.6% purity and is intended for affinity labeling, probe conjugation, and pull-down applications.
- Biotin affinity tag for high-affinity streptavidin binding.
- Terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Short PEG2 spacer improves aqueous solubility and reduces steric hindrance.
- Off-white to light yellow solid with purity approximately 95.6%.
- Stable under recommended storage conditions for extended shelf life.
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | 99.8% | 634.56 g/mol | C24H48BrN3O11 | 50 MG
N3-PEG11-CH2CH2Br is a polyethylene glycol (PEG11) linker with an azide (N3) terminus and a bromide-functionalized ethylene spacer. It is a hydrophilic, viscous liquid used in bioconjugation and click-chemistry workflows to improve aqueous solubility and provide a reactive bromide handle for further modification.
- Azide-terminated PEG11 linker for click chemistry.
- Bromide-functionalized ethylene spacer provides a reactive handle.
- Hydrophilic PEG spacer increases solubility in aqueous media.
- High purity suitable for research applications.
- Recommended storage conditions maintain stability.
Medchemexpress LLC Dbco-PEG4-GGFG-Dxd | 98.4% | 1375.45 g/mol | C72H79FN10O17 | 50 MG
DBCO-PEG4-GGFG-Dxd is a DBCO-functionalized PEG4-linked GGFG peptide drug-linker conjugate incorporating Dxd, a topoisomerase I inhibitor, designed for antibody-drug conjugate (ADC) research and click-chemistry conjugation via its DBCO handle.
- Designed for ADC research and click-chemistry conjugation
- Contains Dxd, a topoisomerase I inhibitor
- Purity 98.4%
- Molecular weight 1375.45 g/mol
- Chemical formula C72H79FN10O17
- Appearance: solid, off-white to light yellow
- Storage: store protected from light; in solvent -80°C (6 months), -20°C (1 month)
- Available in small research quantities including 50 MG
![eMolecules Broadpharm / DSPE-PEG-Fluor 488 MW 2000 / 1mg / 795361461 / BP-40082 / 90.000 / / [null] / 1404.670 / C65H99N5NaO19PS3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502496956.JPG-250.jpg)
eMolecules Broadpharm / DSPE-PEG-Fluor 488 MW 2000 / 1mg / 795361461 / BP-40082 / 90.000 / / [null] / 1404.670 / C65H99N5NaO19PS3
Broadpharm / DSPE-PEG-Fluor 488 MW 2000 / 1mg / 795361461 / BP-40082 / 90.000 / / [null] / 1404.670 / C65H99N5NaO19PS3
eMolecules Hydroxy-PEG3-2-methylacrylate | 2351-42-0 | MFCD30723235 | 1g
Broadpharm | Hydroxy-PEG3-2-methylacrylate | 1g | 550804375 | BP-23567 | 98.000 | 2351-42-0 | MFCD30723235 | 218.249 | C10H18O5
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Medchemexpress LLC ERRα ligand-linker conjugates 1 | 98.8% | 601.42 | C24H20F9N3O5 | 5 MG
ERRα Ligand-linker conjugates 1 is a small-molecule ligand-linker intended as a building block for PROTAC design against estrogen-related receptor alpha (ERRα). It combines an ERRα-binding ligand with a PROTAC-compatible linker to facilitate recruitment of E3 ligases and construction of ERRα degraders. The material is supplied as a solid for medicinal chemistry and degradation studies.
- Designed for PROTAC synthesis
- Incorporates an ERRα-targeting ligand
- Compatible with common E3 ligase recruiters
- High purity suitable for research (98.8%)
- Supplied as a 5 mg solid
- Characterized: molecular weight 601.42, formula C24H20F9N3O5