Protein Modification Reagents
![Medchemexpress LLC 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate | 130955-37-2 | MFCD30723269 | >95.0% | 286.34 g/mol | C10H22O7S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203493.png-250.jpg)
Medchemexpress LLC 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate | 130955-37-2 | MFCD30723269 | >95.0% | 286.34 g/mol | C10H22O7S | 50 MG
m-PEG4-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs m-PEG4-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]
Medchemexpress LLC M-PEG12-DBCO | 96.9% | C44H66N2O14 | 50 MG
m-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Mc-PEG4-Val-Ala-PAB-Exatecan | 99.7% | 1153.21 | C58H69FN8O16 | 5 MG
Mc-PEG4-Val-Ala-PAB-Exatecan is an ADC drug-linker conjugate composed of a cleavable Val-Ala-PAB linker and the DNA topoisomerase I inhibitor Exatecan; supplied for research use in milligram quantities for ADC development and linker-payload studies.
- Purity: 99.7%
- Molecular weight: 1153.21
- Chemical formula: C58H69FN8O16
- Physical state: Solid
- Available in 1 MG, 5 MG, 10 MG, 25 MG, 50 MG, 100 MG
- Storage: -20°C sealed; in solvent -80°C (6 months), -20°C (1 month)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 10 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional linker bearing two dibenzocyclooctyne (DBCO) groups. It is used as a click chemistry reagent for strain-promoted alkyne-azide cycloaddition (SPAAC) and as a PEG linker in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Click chemistry reagent enabling SPAAC with azide-functionalized partners.
- Provides a PEG4 spacer to improve solubility and linker flexibility.
- High solubility in DMSO; manufacturer provides in vitro and in vivo formulation protocols.
- Typical purity around 97.4% and appears as a white to yellow solid.
- Suitable for use in PROTAC and ADC synthesis workflows.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 5 MG
Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker bearing amino and azide functional groups, designed for use in antibody-drug conjugate synthesis and bioconjugation via click chemistry.
- Cleavable 11-unit PEG linker useful for ADC construction.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Amino terminus enables conjugation or further functionalization.
- Improves solubility and flexibility between linked molecules.
- Available in small research quantities for conjugation workflows.
Medchemexpress LLC DSPE-PEG-Amine | 95.0% | 500 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- Ligand for an E3 ubiquitin ligase
- Ligand for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | >95.0% | 406.39 g/mol | C19H22N2O8 | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204285.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | >95.0% | 406.39 g/mol | C19H22N2O8 | 500 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC)
Medchemexpress LLC T-Boc-N-amido-PEG15-Br | 3012589-40-8 | 98.0% | C37H74BrNO17 | 50 MG
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Designed to selectively degrade target proteins
- For research use only
Medchemexpress LLC Ald-Ph-amido-PEG4-C2-NHS ester | 1353011-74-1 | 98.1% | 494.49 g/mol | C23H30N2O10 | 250 MG
A noncleavable 4-unit PEG linker bearing an NHS ester reactive group for antibody-agent conjugation. It is supplied for research use and is amine-reactive for coupling payloads to antibody lysines.
- Noncleavable 4-unit PEG spacer provides hydrophilicity and flexibility.
- NHS ester functionality for amine-reactive conjugation.
- High purity suitable for research applications.
- Soluble in DMSO; protocols provided for in vivo formulations.
- Stable when stored pure at -20°C.
Medchemexpress LLC N-(2-(4-(3,5-Dioxo-1,2,4-triazolidin-4-yl)-2-methoxyphenoxy)ethyl)-4,7,10,13-tetraoxahexadec-ynamide | 99.3% | 508.52 g/mol | C23H32N4O9 | 50 MG
PTAD-PEG4-alkyne is a cleavable four-unit polyethylene glycol linker containing a PTAD moiety and a terminal alkyne. It is intended for bioconjugation and antibody-drug conjugate synthesis, enabling tyrosine-selective conjugation and copper-catalyzed azide-alkyne cycloaddition.
- Cleavable PEG4 linker enabling controlled release
- PTAD moiety for tyrosine-selective conjugation
- Terminal alkyne compatible with CuAAC click chemistry
- High purity (99.3%) suitable for research use
- Soluble in DMSO (125 mg/mL); store powder at -20°C