Protein Modification Reagents
Medchemexpress LLC Dbco-peg3-vc-exatecan | 2754384-70-6 | 96.7% | 1331.44 | C71H79FN10O15 | 5 MG
DBCO-PEG3-VC-Exatecan is a research-grade drug-linker conjugate that couples a cleavable DBCO-PEG3-VC linker to the topoisomerase I inhibitor exatecan, supplied as an off-white to light yellow solid for use in antibody-drug conjugate (ADC) research.
- adc drug-linker conjugate for preclinical and conjugation work
- contains exatecan, a DNA topoisomerase I inhibitor
- cleavable DBCO-PEG3-VC linker suitable for bioconjugation
- high reported purity for research applications
- available in small milligram quantities for formulation and testing
Medchemexpress LLC Dbco-PEG4-Val-Cit-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 g/mol | C88H128N12O19 | 5 MG
DBCO-PEG4-Val-Cit-PAB-MMAE is a cleavable drug-linker conjugate that combines a DBCO-functionalized PEG4-Val-Cit-PAB linker with the cytotoxic payload MMAE. It is supplied as a white to off-white solid for use as a click-chemistry reagent and building block in antibody-drug conjugate synthesis; solutions are unstable and should be prepared fresh.
- Suitable for strain-promoted alkyne-azide cycloaddition (SPAAC)
- Val-Cit-PAB motif provides a cathepsin-cleavable linker
- MMAE payload acts as a tubulin polymerization inhibitor
- High purity supplied (99.18%)
- Provided as a solid; store powder at -20°C
Medchemexpress LLC DSPE-PEG-CHO (aldehyde-terminated DSPE-PEG) | 2000 (average) | 10 MG
DSPE-PEG-CHO (MW 2000) is a heterobifunctional PEGylated phospholipid composed of a DSPE lipid anchor linked to a polyethylene glycol chain terminated with an aldehyde group. Supplied as a powder, it is designed for introducing reactive aldehyde functionality onto liposomes, lipid nanoparticles, or other lipid-based carriers to enable conjugation of biomolecules for targeted delivery and surface modification.
- Aldehyde-terminated PEG enables covalent conjugation to primary amines.
- PEG MW 2000 provides hydrophilicity and steric stabilization of particles.
- DSPE lipid anchor facilitates efficient incorporation into lipid bilayers and nanoparticles.
- DMSO solubility approximately 12.5 mg/mL with ultrasonic warming to 60°C.
- Powder storage at -20°C (up to 3 years); in solvent storage at -80°C for 6 months or -20°C for 1 month.
Worthington Biochemical Corporation COLLAGENASE TYPE 3 100MG
Lower in secondary proteolytic contaminant activities but with typical collagenase activity. Suggested for mammary primary cell isolation. A dialyzed, lyophilized powder.
New England Biolabs, Inc. IdeZ Protease (IgG-specific) – 4000 units
IdeZ Protease (IgG-specific) is a recombinant antibody specific protease that recognizes all human, sheep, monkey, and rabbit IgG subclasses, cleaving specifically at a single recognition site below the hinge region, to yield a homogenous pool of F(ab)2 and Fc fragments. IdeZ Protease more effectively cleaves murine IgG2a than IdeS.
New England Biolabs, Inc. α-Lytic Protease - 100 µg
alpha-Lytic Protease (aLP) cleaves after Threonine (T), Alanine (A), Serine (S) and Valine (V) residues. Its specificity makes it an orthogonal and alternative protease to others commonly used in proteomics applications, including trypsin and chymotrypsin. Peptides generated by aLP are of similar average length to those of Trypsin.
Advanced Biomatrix Extralink-Lite PEGDA Version 2.0 Thiol-reactive crosslinker for HyStem, 10 units x 0.5 mL
Extralink-Lite PEGDA is a thiol-reactive crosslinker designed for use in HyStem kits. Pack comes with Buffer B for reconstitution. HyStem V2.0 kit components are reconstituted with a buffered 1X PBS. The resulting components will also result in a pH neutral isotonic salt hydrogel. The ending pH, osmo, and rheological properties are the same from Version 1.0 to Version 2.0. Extralink is polyethylene diacrylate (PEGDA) with a molecular weight of 3500 Da. It is a thiol-reactive crosslinker that covalently reacts with the thiol groups in Glycosil, Heprasil and Gelin-S to form viscoelastic hydrogels. Extralink Lite vials are >80% acrylated and supplied as the crosslinking component in the HyStem kits. Extralink Lite is used to chemically crosslink Glycosil. Extralink Lite is used in place of Extralink for applications where Gelin-S is not included. The higher relative concentration of Glycosil requires less crosslinker to emulate the gelation time and stiffness of HyStem-C and Hy