Protein Modification Reagents
Cayman Chemical PROTAC CRBN Degrader-1 5mg
A PROTAC that drives CRBN degradation (DC50 = 200 nM in HeLa cells)
Medchemexpress LLC DSPE-PEG-endo-BCN (MW 2000) | 93.3% | 2000 | 1 MG
DSPE-PEG-endo-BCN (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. It can be used in drug delivery research.
- Improves the delivery efficiency of poorly soluble drugs.
- Improves tissue specificity of poorly soluble drugs.
- Can be used in drug delivery research.
Medchemexpress LLC Dbco-peg4-val-cit-pab-pnp | 2226472-28-0 | 98.3% | 1079.16 | C55H66N8O15 | 100 MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable linker reagent designed for constructing antibody-drug conjugates and click-chemistry bioconjugates. It combines a strain-promoted alkyne-azide cycloaddition (DBCO) handle with a Val-Cit protease-cleavable dipeptide and a PAB-PNP leaving group to enable enzyme-triggered payload release and efficient payload attachment. The compound is supplied as a characterized solid for research use.
eMolecules Amino-PEG3-CH2CO2H | 134978-99-7 | MFCD24479841 | 1g
Broadpharm | Amino-PEG3-CH2CO2H | 1g | 347153871 | BP-23635 | 98.000 | 134978-99-7 | MFCD24479841 | 207.226 | C8H17NO5
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Medchemexpress LLC DBCO-mPEG | 00-00-0 | 98.4% | 10MG
DBCO-mPEG is a DBCO-functionalized methoxy-polyethylene glycol (mPEG) reagent with an average molecular weight of 5,000 Da. Supplied as a white to light yellow solid for research use, it enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) to conjugate azide-containing molecules and serves as a spacer or linker in bioconjugation and PROTAC synthesis.
- Enables copper-free click chemistry (SPAAC) with azide-containing partners.
- Provides a methoxy-terminated PEG spacer with average MW 5,000 Da.
- Supplied as a solid with high reported purity (~98.4%).
- Suitable for bioconjugation, linker construction, and PROTAC applications.
- Stable when stored at -20°C under inert atmosphere; in solution, store at -80°C for long-term.
eMolecules Mal-PEG2-acid | Broadpharm | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 0.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 1g | 335341196
Mal-PEG2-acid | Broadpharm | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 0.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 1g | 335341196
Medchemexpress LLC Dmg-peg 2000 | 160743-62-4 | 98.4% | 2000 (Average) | 50 MG
DMG-PEG 2000 is utilized in the preparation of liposomes for siRNA delivery, enhancing transfection efficiency in vitro. It is also employed for lipid nanoparticles in an oral plasmid DNA delivery approach in vivo, through surface modification, to improve mucus permeability and delivery efficiency of the nanoparticles.
- Used for liposome preparation for siRNA delivery with improved transfection efficiency in vitro.
- Used for lipid nanoparticles for oral plasmid DNA delivery with improved mucus permeability and delivery efficiency in vivo.
eMolecules Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Medchemexpress LLC Bis-PEG9-NHS ester 100mg | 1008402-79-6 | 708.71 | C30H48N2O17 | 100 MG
Bis-PEG9-NHS ester is a homobifunctional PEG-based linker containing two N-hydroxysuccinimide (NHS) ester reactive groups, used to conjugate primary amines in proteins and small molecules. It is commonly applied as a spacer/linker in PROTAC and ADC synthesis. The reagent is supplied as a viscous liquid with high purity and is moisture sensitive; store sealed and protected from humidity.
- Homobifunctional PEG9 spacer with two NHS ester reactive termini.
- Enables efficient amine conjugation for ADCs, PROTACs, and bioconjugation.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- High purity (≥98%) for reproducible conjugation performance.
- Viscous liquid; moisture sensitive-store sealed and avoid humidity.
Medchemexpress LLC Mal-PEG4-PFP ester | 1415800-42-8 | MFCD28556926 | 95.4% | 511.39 g/mol | C21H22F5NO8 | 250 MG
Mal-PEG4-PFP ester is a noncleavable antibody-drug conjugate (ADC) linker composed of a maleimide group, a four-unit polyethylene glycol (PEG4) spacer, and a pentafluorophenyl (PFP) ester reactive group. It is supplied as a viscous liquid for research use only and is not intended for therapeutic use.
- Noncleavable ADC linker suitable for conjugation strategies.
- Maleimide group enables thiol-selective conjugation.
- PFG ester (pentafluorophenyl) is reactive toward amines for efficient coupling.
- PEG4 spacer increases solubility and provides distance between conjugated components.
- High purity (95.4%) for research applications.
- Molecular weight 511.39 g/mol and formula C21H22F5NO8.
- Appearance viscous liquid, off-white to light brown.
- Recommended storage: pure form -20°C for long term; in solvent store cold as specified.
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2,835.50 g/mol | C149H224N22O32 | 50 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a DBCO reactive group with a cleavable valine-citrulline linker, a p-aminobenzyl self-immolative spacer, and dual MMAE payloads. It is supplied as a purified powder for use in bio-conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a DBCO reactive group for copper-free click chemistry (SPAAC).
- Includes a PEG2 spacer for improved solubility and flexibility.
- Features a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer.
- Contains two MMAE payloads for potent cytotoxic delivery.
- High purity, typically 99.2%.
- Supplied as a powder suitable for ADC construction and conjugation.
Medchemexpress LLC Mal-PEG2-NH2 TFA | 660843-23-2 | 99.37% | 342.27 | 100 MG
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are composed of two different ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Appearance: oil
- Color: light yellow to yellow
- Shipping: room temperature in continental US
- Storage: -20°C, stored under nitrogen, away from moisture
- Solubility (in vitro): DMSO: 100 mg/mL (292.17 mM; requires ultrasonic)
Medchemexpress LLC Thp-peg4-pyrrolidine(n-boc)-ch2oh | 2378261-80-2 | 95.0% | 50 MG
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523). It is for research use only. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTAC K-Ras degrader-1
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins