Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.

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4,606 – 4,620 of 5,663 results

4,606

Medchemexpress LLC DNP-PEG4-NHS ester | 858126-78-0 | 96.81% | C21H28N4O12 | 50 MG

DNP-PEG4-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs feature two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other for the protein of interest.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the intracellular ubiquitin-proteasome system
Selectively degrades target proteins

Pricing & Availability

4,607

eMolecules 859230-20-9 | t-Boc-N-amido-PEG4-NHS ester | Broadpharm | MFCD20228887 | 462.496 | C20H34N2O10 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 340377001

t-Boc-N-amido-PEG4-NHS ester | Broadpharm | 859230-20-9 | MFCD20228887 | 462.496 | C20H34N2O10 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 340377001

Pricing & Availability

4,608

eMolecules 2126805-02-3 | endo-BCN-PEG8-acid | Broadpharm | MFCD23704193 | 617.733 | C30H51NO12 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 25mg | 354974895

endo-BCN-PEG8-acid | Broadpharm | 2126805-02-3 | MFCD23704193 | 617.733 | C30H51NO12 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 25mg | 354974895

Pricing & Availability

4,609

Medchemexpress LLC DBCO-PEG4-PFP ester | 00-00-0 | 95.0% | C36H35F5N2O8 | 10MG

DBCO-PEG4-PFP ester is a PEG-based linker and click-chemistry reagent used for bioconjugation and PROTAC linker construction. It combines a dibenzocyclooctyne (DBCO) group for strain-promoted alkyne-azide cycloaddition (SPAAC) with a pentafluorophenyl (PFP) ester reactive handle for coupling to nucleophiles such as amines.

Enables copper-free click reactions with azide-functionalized partners.
Provides an active pentafluorophenyl ester for efficient amide bond formation with amines.
Includes a PEG4 spacer to improve solubility and reduce steric hindrance.
Suitable for PROTAC linker synthesis and general bioconjugation workflows.
High purity and recommended storage support reproducible laboratory results.

Pricing & Availability

4,610

Medchemexpress LLC THP-PEG4-Pyrrolidine(N-Boc)-CH2OH | 2378261-80-2 | 95.0% | 25 MG

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker primarily used in the synthesis of PROTAC K-Ras Degrader-1. This compound serves as a crucial component for designing degraders that target specific proteins, utilizing the intracellular ubiquitin-proteasome system. It is intended for research use only.

PEG-based PROTAC linker
Used in the synthesis of PROTAC K-Ras degrader-1
Purity of 95.0%
Molecular weight is 477.59
Molecular formula is C23H43NO9
Appearance is a colorless to light yellow liquid
Store at -20°C under nitrogen
Soluble in DMSO

Pricing & Availability

4,611

Medchemexpress LLC TCO-PEG5-C2-Mal | 2748951-17-7 | 95.0% | 512.59 | 1 MG

TCO-PEG5-C2-Mal is a heterobifunctional linker that can be used for tetrazine ligation and sulfhydryl conjugation. It is for research use only and not sold to patients.

Heterobifunctional linker.
Can be used for tetrazine ligation.
Can be used for sulfhydryl conjugation.

Pricing & Availability

4,612

Medchemexpress LLC HS-PEG-SH (MW 3400) | 97.0% | 50 MG

HS-PEG-SH (MW 3400) is a linear homobifunctional PEG cross-linker designed for various biochemical applications. It is utilized in drug delivery systems and for the preparation of PEG hydrogels, offering versatility for research purposes. This product has an average molecular weight of 3400 and a purity of 97.0%.

Linear homobifunctional PEG
Cross-linker for biochemical applications
Utilized for drug delivery
Suitable for preparing PEG hydrogels
97.0% purity
Average molecular weight of 3400
Appears as a solid
Color ranges from white to light yellow

Pricing & Availability

4,613

eMolecules 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100mg | 642097511

Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100mg | 642097511

Pricing & Availability

4,614

eMolecules 1895922-73-2 | Aminooxy-PEG3-bromide | Broadpharm | MFCD29764339 | 272.139 | C8H18BrNO4 | 98.000 | NOCCOCCOCCOCCBr | 1g | 311074478

Aminooxy-PEG3-bromide | Broadpharm | 1895922-73-2 | MFCD29764339 | 272.139 | C8H18BrNO4 | 98.000 | NOCCOCCOCCOCCBr | 1g | 311074478

Pricing & Availability

4,615

eMolecules 1807530-10-4 | AZIDO-PEG3-ALDEHYDE | AstaTech | MFCD28976706 | 231.252 | C9H17N3O4 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCC=O | 0.25g | 570586065

AZIDO-PEG3-ALDEHYDE | AstaTech | 1807530-10-4 | MFCD28976706 | 231.252 | C9H17N3O4 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCC=O | 0.25g | 570586065

Pricing & Availability

4,616

eMolecules 1345681-74-4 | Mal-PEG1-PNP-carbonate | Broadpharm350.283 | C15H14N2O8 | 98.000 | [O-][N+](=O)c1ccc(OC(=O)OCCOCCN2C(=O)C=CC2=O)cc1 | 100mg | 573896599

Mal-PEG1-PNP-carbonate | Broadpharm | 1345681-74-4350.283 | C15H14N2O8 | 98.000 | [O-][N+](=O)c1ccc(OC(=O)OCCOCCN2C(=O)C=CC2=O)cc1 | 100mg | 573896599

Pricing & Availability

4,617

eMolecules 2839527-02-3 | N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 | Broadpharm | MFCD30182067 | 907.540 | C49H67ClN4O10 | 95.000 | [Cl-].COCCOCCOCCOCC[N+]1=C(\C=C\C=C\C=C2\N(CCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 311074481

N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 | Broadpharm | 2839527-02-3 | MFCD30182067 | 907.540 | C49H67ClN4O10 | 95.000 | [Cl-].COCCOCCOCCOCC[N+]1=C(\C=C\C=C\C=C2\N(CCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 311074481

Pricing & Availability

4,618

Research Products International Corp PEG 8000, 25 KG

Ultrapure white crystals for molecular biology applications such as precipitation of DNA, nucleic acids, hybridization and fusion of mammalian cells.Melting Point: 55°-60°C

Pricing & Availability

4,619

eMolecules 2135793-73-4 | m-PEG12-acid | Broadpharm | MFCD08274611 | 588.688 | C26H52O14 | 90.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O | 1g | 200622525

m-PEG12-acid | Broadpharm | 2135793-73-4 | MFCD08274611 | 588.688 | C26H52O14 | 90.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O | 1g | 200622525

Pricing & Availability

4,620

Broadpharm endo-BCN-PEG8-NHS ester | 1608140-48-2 | MFCD31692212 | 50mg

endo-BCN-PEG8-NHS ester | Putity: 98% | MW: 714.8 | 1608140-48-2 | MFCD31692212 | 50mg

Pricing & Availability

Protein Modification Reagents

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Medchemexpress LLC DNP-PEG4-NHS ester | 858126-78-0 | 96.81% | C21H28N4O12 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DBCO-PEG4-PFP ester | 00-00-0 | 95.0% | C36H35F5N2O8 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC THP-PEG4-Pyrrolidine(N-Boc)-CH2OH | 2378261-80-2 | 95.0% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TCO-PEG5-C2-Mal | 2748951-17-7 | 95.0% | 512.59 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HS-PEG-SH (MW 3400) | 97.0% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Research Products International Corp PEG 8000, 25 KG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More