Cytokines and Receptors Reagents and Kits
Abcam SB 297006, CCR3 antagonist, 50MG
MW 342.35 g/mol, Purity >99%. Highly potent, selective CCR3 antagonist (IC₅₀ = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca²+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC₅₀ values are 210, 90 and 80 nM, respectively).
The product is subject to the following: Abcam Restricted Use Statement
![Research Products International Corp Zeatin Riboside [9-(B-D-Ribofuranosyl)-Trans-Zeatin], 250 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-Z11402-0.25.JPG-250.jpg)
Research Products International Corp Zeatin Riboside [9-(B-D-Ribofuranosyl)-Trans-Zeatin], 250 Milligrams
Naturally occurring cytokinin riboside. Main effects in tissue culture systems include control of shoot growth and formation, cell division and inhibition of leaf senescence. Chromatographically purified and recrystallized. Plant cell culture tested.
Mixed isomers: trans-isomer 97%, cis-isomer >2%.
STEMCELL Technologies Mouse Recombinant IL-33, Size: 1000 µg
Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to the ST2 receptor and activates NF-kB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz et al.; Yasuda et al.). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections (Liew; Yasuda et al.). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka et al.).
STEMCELL Technologies Human Recombinant IL-11, Size: 1000 µg
Use interleukin 11 (IL-11) to induce the proliferation of hematopoietic stem cells (Lemoli et al. Exp Hematol, 1993) and megakaryocytic progenitor cells (Bruno et al. Exp Hematol, 1991), the maturation of megakaryocytes (Burstein et al. J Cell Physiol, 1992), and the production of platelets (Neben et al. Blood, 1993). IL-11 is produced by a variety of cell types including hematopoietic, mesenchymal, epithelial, and neuronal cells. The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs (Cameron et al. Cytokine Growth Factor Rev, 2015). Human recombinant IL-11 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 10 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Adipogenic inhibitory factor, AGIF, Interleukin-11, Oprelvekin.
STEMCELL Technologies Mouse Recombinant IL-1 alpha, Size: 1000 µg
Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes have high levels of intracellular IL-1α precursor, which is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Rider et al.; Cohen et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
STEMCELL Technologies Human Recombinant IL-31, Size: 1000 µg
Interleukin 31 (IL-31), a four-helix bundle inflammatory cytokine, belongs to the IL-6 cytokine family which includes IL-6 (Catalog #78050), oncostatin M (Catalog #78094), leukemia inhibitory factor (LIF; Catalog #78055), and cardiotrophin-1 (Catalog #78160; Dillon et al.). IL-31 signals through a heterodimer composed of IL-31RA (also known as gp130-like receptor or GPL) and the oncostatin-M receptor (OSMR), both of which are expressed on monocytes (Diveu et al.; Ghilardi et al.), epithelial cells (Ip et al.), and keratinocytes (Kato et al.). Signaling through the GPL/OSMR complex activates the JAK/STAT, RAS/ERK, and PI3K/AKT signaling pathways, resulting in the downstream activation of STAT1, STAT3, and STAT5 transcription factors (Cornelissen et al.; Dambacher et al.; Dillon et al.; Ip et al.). IL-31 responses have been associated with allergic responses and inflammatory skin diseases including atopic dermatitis (Cornelissen et al.; Gangemi et al.).
STEMCELL Technologies Mouse Recombinant IL-11, Size: 1000 µg
Use interleukin 11 (IL-11) together with IL-3, IL-6, and stem cell factor to induce the expansion and proliferation of colony-forming cells in vitro (Peters et al. Blood, 1996). In combination with IL-3, IL-11 significantly enhances the growth of megakaryocytic colonies in vitro, suggesting its role in augmenting mouse megakaryopoiesis (Yonemura et al. Exp Hematol, 1992). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. Expressed in a wide range of normal adult mouse tissues, IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs (Cameron et al. Cytokine Growth Factor Rev, 2015). Mouse recombinant IL-11 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 250 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Adipogenic inhibitory factor, AGIF, Interleukin-11, Oprelvekin.
![Research Products International Corp Zeatin, Trans Isomer [6-(4-Hydroxy-3-methylbut-2-enylamino)purine)], 250 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-Z11400-0.25.JPG-250.jpg)
Research Products International Corp Zeatin, Trans Isomer [6-(4-Hydroxy-3-methylbut-2-enylamino)purine)], 250 Milligrams
Naturally occurring cytokinin growth regulator. Promotes cell division and also influences other steps of the cell cycle. High concentrations produce advantitious shoot formation. Other uses include prevention of leaf senescence, reversal of toxin affects on shoots and inhibiting excessive root formation. Off white to yellow crystals. Plant cell culture tested.
STEMCELL Technologies Human Recombinant IL-1 beta, ACF, Size: 100 µg
Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
STEMCELL Technologies Mouse Recombinant IL-19, Size: 50 µg
Interleukin 19 (IL-19) is a member of the IL-10 cytokine family and is produced by keratinocytes, B cells, and monocytes (Romer et al.; Wolk et al.). Expression of IL-19 can be induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS; Gallagher et al.). IL-19 is considered to be a proinflammatory cytokine, as it upregulates IL-6 and tumor necrosis factor alpha (TNF-α; Liao et al. 2002). IL-19 binds the IL-20 receptor complex (IL-20R) which comprises IL-20R alpha and IL-20R beta to activate the STAT3 pathway (Dumoutier et al.). IL-19 also induces T-helper cell differentiation towards a Th2 response, resulting in the production of IL-10 and additional IL-19 (Liao et al. 2002; Liao et al. 2004). IL-19 has been implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis.
STEMCELL Technologies Human Recombinant IL-1 alpha, Size: 1000 µg
Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes, have high levels of intracellular IL-1α precursor. The precursor is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Cohen et al.; Rider et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). Studies in mice show that IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
STEMCELL Technologies Mouse Recombinant IL-6, Size: 1000 µg
Modulate a variety of biological activities in immune regulation, hematopoiesis, and oncogenesis with interleukin 6 (IL-6). IL-6 is a pleiotropic growth factor that stimulates the proliferation of B cells, T cells, and hybridoma cells in combination with other factors (Tanaka et al. Cold Spring Harb Perspect Biol, 2014). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system also activates the JAK/STAT signaling pathway (Mihara et al. Clin Sci, 2012). Mouse recombinant IL-6 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 50 pg/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: B cell differentiation factor, BSF-2, IFN-β2, Interleukin-6.
Abcam Cytokine Array Mouse Cytokine Antibody Array (Membrane, 32 Targets)
Cytokine Array Mouse Cytokine Antibody Array (Membrane, 32 Targets)
The product is subject to the following: Abcam Restricted Use Statement
STEMCELL Technologies Human Recombinant IL-10, ACF, Size: 100 ug
Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of a-helical folds. Upon binding to its receptor IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells macrophages and CD4 T cells as well as mast cells NK cells neutrophils and B cells under specific stimulating conditions (Saraiva O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes and is important for the function of T regulatory cells. IL-10 also enhances B cell proliferation immunoglobulin secretion and class II MHC expression while IL-10 produced by macrophages inhibits activation of neighboring macrophages thus allowing a level of self-regulation (Ouyang et al.). This product is animal component-free.