Mass-Tagged Crosslinkers
Cayman Chemical 8-Iso ProstaglndIn F2a-d4 25ug
An a2-AR (EC50s 1 receptor antagonist binds to a2A- a2B- and a2C-ARs (Kis 13 38 and 1820 nM respectively) and selectively to I1 over I2 receptors (Kis 52 and 10000 nM respectively) binds to putative I3 receptors on human pancreatic islets of Langerhans and stimulates insulin secretion at 100 M binds to rat RIN-5AH insulinoma cell membranes (IC50g 32 nM) and stimulates insulin secretion at 100 M lowers basal blood glucose levels in mice at 5 mg/kg increases L-DOPA synthesis in rat cortex and hippocampus by 77 and 57 respectively at 10 mg/kg
Cayman Chemical Bosentn-d4 25mg
Selectively activates hM3Dq (EC50 1 7 nM) a DREADD derived from the human muscarinic acetylcholine M3 receptor
Cayman Chemical AbIrateron Acetate-d4 10mg
A pan-FGFR inhibitor (IC50s 2 8 2 6 6 4 6 and 7 nM for FGFR1 FGFR2 FGFR3 FGFR4 and VEGFR2 respectively) inhibits proliferation of KMS-11 OPM-2 SNU-16 and KATO-III cancer cells in vitro and in tumor xenografts in mice
Cayman Chemical 2-NonylquInolIn-4 1H-on-d4 5mg
A PROTAC that drives WDR5 degradation induces degradation of WDR5 in MV4-11 cells (DC50 53 nM) reduces WDR5 protein levels but not levels of mRNA encoding WDR5 in MV4-11 cells at 1 UM
Cayman Chemical DarIfenacIn-d4 10mg
A non-essential amino acid produced by directBdecarboxylation of L-aspartate by L-aspartateBdecarboxylase or transamination of pyruvate in the glucose-alanine cycle a precursor for gluconeogenesis dysregulation of its metabolism is associated with various disease states
Cayman Chemical MoclobemIde-d4 10mg
A noncompetitive antagonist and inverse agonist of mGluR5 that binds to an allosteric site inhibits quisqualate-induced intracellular calcium mobilization in HEK293 cells expressing the human receptor (IC50 58 nM) inhibits basal activity of mGluR5 in a cell-based assay (IC50 84 nM) reduces stress-induced hyperthermia in mice at 10 and 30 mg/kg increases drinking time in the Vogel conflict test in rats at 30 mg/kg induces analgesia in the formalin test in mice at 30 mg/kg
Cayman Chemical -NornIcotIn-d4 10mg
A derivative of betulin has been used in the synthesis of a-glucosidase inhibitors
Cayman Chemical TolfenamIc AcId-d4 5mg
An internal standard for the quantification of mycophenolate mofetil by GC- or LC-MS
Cayman Chemical Sulfamethoxazole-d4 10mg
A partial agonist for a4B2 subunit-containing nAChRs (EC50 0 18 UM) selective for a4B2 over a2B4 a4B4 a3B4 a3B2 and a7 subunit-containing nAChRs (EC50s 14 12 5 30 100 and 100 UM respectively) increases dopamine cell firing in the rat VTA in vitro enhances inhibitory synaptic transmission in dorsal horn neurons via a4B2 subunit-containing nAChRs reduces formalin-induced paw-licking time in mice at 3 and 10 mg/kg reverses scopolamine-induced cognitive deficits in rats in a step-through passive avoidance test at 3 and 6 Umol/kg
Cayman Chemical Sulfamethoxazole-d4 1mg
A ferroptosis inhibitor inhibits erastin-induced cell death in HT-1080 cells from 0 01-1 M contains a diyne small vibrational tag and has been used to assess localization of ferrostatin-1 in HT-1080 cells using stimulated Ramen scattering microscopy
Cayman Chemical DMABA-d4 NHS ester 5mg
An internal standard for the quantification of abnormal cannabidiol by GC- or LC-MS intended for research and forensic applications
Cayman Chemical DMABA-d4 NHS ester 25mg
A stable analog of 9-THC and AEA exhibits high-affinity for the CB1 and CB2 receptors (Ki 210 and 30 nM respectively) behaves primarily as a CB1 receptor partial agonist and a CB2 receptor neutral antagonist in vitro
Cayman Chemical NIcorndIl-d4 10mg
An analytical reference standard categorized as a utopioid intended for research and forensic applications
Cayman Chemical N-NItroso DesloratdIn-d4 5mg
A plasmalogen serum levels are decreased in dogs with myxomatous mitral valve disease fed a diet including medium chain triglycerides fish oil carnitine precursors magnesium and antioxidants
Cayman Chemical 5-BromopentnoIc AcId-d4 5mg
An inhibitor of GLS1 (IC50 0 021 M) inhibits the growth of NCI H1703 NSCLC cells in vitro (GI50 0 011 M) reduces tumor growth increases tumor levels of glutamine and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model at 100 mg/kg